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Discovery of how a gene that regulates factors involved in bacteria pathogenicity acts
Date:6/14/2013

rch team has discovered that there is an inverse correlation between glycogen production and the production of structures involved in bacterial pathogenicity. "In our case we found that the alteration in the expression of glgS, which is only present in the group of enterobacteria (E. coli, species of the Salmonella genus, Yersinia pestis, etc.), has an effect on the production of structures involved in bacterial pathogenicity which, indirectly, affects the capacity to produce glycol gen. "The finding may provide clues to future strategies for combating bacterial infections by modulating glycogen production, a substance that many bacteria of all kinds can accumulate.

Resistance to antibiotics

In a world in which bacteria strains are becoming increasingly resistant to antibiotics, the researchers are sending an optimistic message: "by encouraging glycogen production in bacteria we may be able to hamper the creation of these structures and cause the bacteria to stop moving and proliferate in the medium and/or stick to surfaces and therefore would stop being pathogens."

The research team has protected the discovery relating to this procedure to try and combat bacterial infections. The next step is to find substances that boost glycogen production in bacteria. "We have incorporated a gene into the pathogenic bacteria that causes them to produce large quantities of glycogen; that way we can stop them "running" and reduce their pathogenicity. But we want to go further: we want to find substances that once applied to wounds or surfaces or once administered to patients with bacterial diseases, will encourage the accumulation of bacterial glycogen and the resulting reduction in the capacity of the bacteria to become adhered, invade, proliferate."


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Contact: Oihane Lakar Iraizoz
o.lakar@elhuyar.com
34-943-363-040
Elhuyar Fundazioa
Source:Eurekalert

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