Navigation Links
Discovery of cell division 'master controller' may improve understanding and treatment of cancer
Date:9/11/2013

this process held that chromosomes and microtubules pair up individually to find the correct attachment, like conventional dating. However, our results show that the system is more like speed dating. All the chromosomes have to try many connections with microtubules in a short amount of time. Then they all make their final choices at the same time. Cyclin A acts like a timekeeper or referee to make sure no one makes bad connections prematurely."

In normal cells, persistent cyclin A expression prevents the stabilization of microtubules bound to kinetochores even in cells with aligned chromosomes. As levels of cyclin A decline, microtubule attachments become stable, allowing the chromosomes to be divided correctly as cell division proceeds. In contrast, in cyclin A-deficient cells, microtubule attachments are prematurely stabilized. Consequently, these cells may fail to correct errors, leading to higher rates of chromosome mis-segregation.

"Many cancer cells continuously mis-segregate their chromosomes," says Kabeche. "The major cause is improper kinetochoremicrotubule attachments. Therefore, understanding how kinetochoremicrotubule attachments are regulated throughout cell division is important, not only for furthering our understanding of cell division, but also for allowing us to correct these problems in cancer cells."


'/>"/>

Contact: Derik Hertel
derik.hertel@dartmouth.edu
603-650-1211
The Geisel School of Medicine at Dartmouth
Source:Eurekalert

Page: 1 2

Related biology news :

1. Discovery of a molecule that initiates maturation of mammalian eggs can lead to more IVF pregnancies
2. Annual Drug Discovery Conferences Being Held in Boston MA, Spring 2012
3. Discovery provides blueprint for new drugs that can inhibit hepatitis C virus
4. Unexpected discovery reveals a new mechanism for how the cerebellum extracts signal from noise
5. Discovery offers insight into treating viral stomach flu
6. Breast cancer risk gene discovery fast tracked by new technology
7. Tales from the crypt lead researchers to cancer discovery
8. New discovery may lead to effective prevention and treatment of graft-versus-host dsease
9. Stomata development in plants unraveled -- a valuable discovery for environmental research
10. Discovery reveals chromosomes organize into yarns
11. Bacteria discovery could lead to antibiotics alternatives
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... such as heart disease, epilepsy and pain, making them ... is still much scientists do not know about the ... into the structure of sodium channels and, specifically, one ... responsible for ,fine-tuning, the activity of the channel. The ... the Journal of Biological Chemistry . , Nerves ...
(Date:4/17/2014)... the genetic information of DNA is used to ... numerous different functions in living organisms. Messenger RNA ... expression, by relating the genetic information of DNA ... , By examining the different types and ... at a given time, researchers can determine which ...
(Date:4/17/2014)... led by the Australian National University (ANU), have ... and deep-sea temperature variability over the past 5.3 ... understand the climate surrounding ice ages over the ... the relationship between carbon dioxide levels, global temperatures ... University of Southampton (UoS) and the National Oceanography ...
Breaking Biology News(10 mins):Structure of sodium channels different than previously believed 2Rapid and accurate mRNA detection in plant tissues 2Ancient sea-levels give new clues on ice ages 2
... contain genetically identical clones up to 15 kilometers apart, suggesting ... of years old, as reported in the Feb. 1 issue ... The seagrass, Posidonia oceanica , reproduces asexually, which can ... old. To investigate the P. oceanica meadow, the ...
... suffering from severe pulmonary diseases including emphysema, lung cancer ... the best chance for survival. The surgical procedure, however, ... lungs and rejection of transplanted tissue by the recipient,s ... Vermont Lung Center (Principal Investigator for this project) in ...
... innovative products and technologies that promote healing of difficult, ... described in the premier issue of Advances in ... Ann Liebert, Inc. ( http://www.liebertpub.com ) and an Official ... available free online at http://www.liebertpub.com/wound Several ...
Cached Biology News:Lungs clothed in fresh cells offer new hope for transplant patients 2Lungs clothed in fresh cells offer new hope for transplant patients 3
(Date:1/14/2014)... Date: Friday, April 11, 2014 , Time: ... 1360 Almshouse Road, Warrington, Pa. , Details: The ... to finding a cure for hepatitis B and improving the ... annual Crystal Ball on Friday, April 11 at Warrington Country ...
(Date:1/14/2014)... provider of strategic communications services to corporations and organizations preparing for ... United States and Europe , today ... to the firm,s Washington, D.C. office. ... years of service as Associate Commissioner for the Office of External ...
(Date:1/14/2014)... , Jan. 14, 2014 The largest international ... medicinal plants and therapeutic derivatives thereof has endorsed ... and researchers about the challenges of adulterated herb ... ) The Society for Medicinal ...
(Date:1/14/2014)... Toronto, Canada (PRWEB) January 14, 2014 ... and its motives and methods in product development and ... of the industry. This mistrust, fueled by concerns about ... further fed by reports of spectacular fines to the ...
Breaking Biology Technology:Hepatitis B Foundation to Host Annual Crystal Ball Gala 2Former FDA Associate Commissioner Returns To 3D Communications 2World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 2World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 3World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 4World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 5World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 6World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 7World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 8The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 2The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 3
... Life Corporation Limited (HKLife) announces further developments of ... EFADchip technology at the BIO 2009 ... in Atlanta, through 18-21 May 2009. The BIO ... the biotechnology industry and attracts the biggest names ...
... Anti-Cancer Compound Discovered During Joint Research EMERYVILLE, Calif., May ... ) today announced that it has filed a complaint ... District of California asserting its rights to a Phase ... and Bayer. In its complaint, Onyx seeks a ...
... Of the 92 naturally occurring elements, add another to the ... Ph.D., professor of physics in Arts & Sciences at Washington ... doctoral student at the time discovered that europium becomes ... atmospheres) of pressure, making it the 53rd known elemental superconductor ...
Cached Biology Technology:A New Era in the Application of Lab-on-a-Chip to Rapid Point-of-Care Diagnosis 2A New Era in the Application of Lab-on-a-Chip to Rapid Point-of-Care Diagnosis 3Onyx Pharmaceuticals Files Complaint Against Bayer Corporation 2Europium discovery 2Europium discovery 3
... corresponds to amino acids 2-105 from human ... successfully used in Western blot, immunocytochemistry and ... antibody detects an ~ 60 kDa protein ... been used in immunoprecipitation and immunocytochemical procedures. ...
... suit the widest possible range of sample ... Labware carriers can be placed at any ... for the user, thanks to a numbered ... guided into position. This allows easy removal ...
... was developed in the late 1960s by ... the earliest commercial pioneers of immunoassay in ... in 1987. Sac-Cel rapidly found favour with ... "in house" radioimmunoassays, and became a benchmark ...
... N,N- bis- (3-D-Gluconamidopropyl)deoxycholamide ... analog of CHAPS and CHAPSO. Has reduced ... anion exchange chromatography on DEAE-cellulose. Aggregation number: ... Soluble in H 2 O. Aggregation number ...
Biology Products: