Navigation Links
Discovery of a new molecular mechanism that guides visual nerves towards the brain
Date:1/7/2010

The laboratory of Dr. Frdric Charron, in Montreal, made this discovery

Montral, January 7, 2010 The laboratory of Dr. Frdric Charron, a researcher at the Institut de recherches cliniques de Montral (IRCM), has discovered a new molecular mechanism that permits the guidance of visual nerves towards the brain. Their findings have been published in the current issue of the Journal of Neuroscience. The research was conducted in collaboration with Dr. Tomomi Shimogori from the RIKEN Brain Science Institute, in Japan. Pierre Fabre, a doctoral student in Dr. Charron's research unit, is the article's first author.

To correctly establish nervous circuits, attractive and repulsive molecules are required to guide growing axons to their appropriate targets. One such molecule is Sonic Hedgehog (Shh). "Using genetic evidence and in utero manipulations in mice, we were able to demonstrate that the Sonic Hedgehog (Shh) molecular pathway is required for the guidance of retinal axons within the optic chiasm," specified Pierre Fabre. This guidance, which acts through repulsion, relies on the Boc receptor, which becomes therefore a prime target for the development of therapies that could stimulate axonal growth after injury or in neurodegenerative disorders.

Moreover, the authors have shed new light on the molecular mechanisms involved in the formation of the visual system. The optic chiasm is the crossroad of optic nerves stemming from both eyes and allows the brain to integrate binocular visual information, a crucial process for establishing 3D vision. "By showing that Boc and Shh play an important role in this neurobiological development process, we have identified a new molecular pathway required in the formation of the visual system," added Dr. Charron.

"CIHR is proud to support research such as Dr. Charron's, which will improve our understanding of visual development," says Dr. Anthony Phillips, Scientific Director of the Canadian Institutes of Health Research (CIHR) Institute of Neurosciences, Mental Health and Addiction. "The discovery of the new molecular mechanism will pave the way for research into neurodegenerative disorders and, eventually, treatment."


'/>"/>

Contact: Olivier Lagueux
olivier.lagueux@ircm.qc.ca
514-987-5555
Institut de recherches cliniques de Montreal
Source:Eurekalert

Related biology news :

1. New discovery by Harvard scientists aims to correct cellular defects leading to diabetes
2. New year, new vitamin C discovery: It cures mice with accelerated aging disease
3. Emerald BioStructures announces discovery of small molecule modulators of PDE4
4. UGA researchers lead team in discovery involving devastating freshwater fish parasite, Ich
5. Discovery makes brain tumor cells more responsive to radiation
6. Discovery of the Jekyll-and-Hyde factors in coral bleaching
7. Rocket science leads to new whale discovery
8. A year after discovery, Congos mother lode of gorillas remains vulnerable
9. Cancer metabolism discovery uncovers new role of IDH1 gene mutation in brain cancer
10. Its a gas: New discovery may lead to heartier, high-yielding plants
11. Discovery of new type of immune cells regulating inflammation in chronic diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/3/2016)... , June 3, 2016 ... von Nepal hat ... Lieferung hochsicherer geprägter Kennzeichen, einschließlich Personalisierung, Registrierung ... in der Produktion und Implementierung von Identitätsmanagementlösungen. ... Ausschreibung im Januar teilgenommen, aber Decatur wurde ...
(Date:6/1/2016)... -- Favorable Government Initiatives Coupled With Implementation ... to Boost Global Biometrics System Market Through 2021  ... " Global Biometrics Market By Type, By End ... - 2021", the global biometrics market is projected to ... growing security concerns across various end use sectors such ...
(Date:5/12/2016)... 12, 2016 WearablesResearch.com , a brand ... overview results from the Q1 wave of its quarterly ... was consumers, receptivity to a program where they would ... health insurance company. "We were surprised to ... Michael LaColla , CEO of Troubadour Research, "primarily ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... , June 23, 2016  Blueprint Bio, a ... discoveries to the medical community, has closed its Series ... Matthew Nunez . "We have received a ... the capital we need to meet our current goals," ... provide us the runway to complete validation on the ...
(Date:6/23/2016)... , June 23, 2016 On Wednesday, ... at 4,833.32, down 0.22%; the Dow Jones Industrial Average edged ... closed at 2,085.45, down 0.17%. Stock-Callers.com has initiated coverage on ... ), Nektar Therapeutics (NASDAQ: NKTR ), Aralez Pharmaceuticals ... (NASDAQ: BIND ). Learn more about these stocks ...
(Date:6/23/2016)... ... June 23, 2016 , ... Regulatory Compliance Associates® Inc. ... a free webinar on Performing Quality Investigations: Getting to Root Cause. ... at no charge. , Incomplete investigations are still a major concern to the ...
(Date:6/23/2016)... June 22, 2016  Amgen (NASDAQ: AMGN ... QB3@953 life sciences incubator to accelerate the ... shared laboratory space at QB3@953 was created to help ... obstacle for many early stage organizations - access to ... sponsorship, Amgen launched two "Amgen Golden Ticket" awards, providing ...
Breaking Biology Technology: