Navigation Links
Discovery of a new molecular mechanism that guides visual nerves towards the brain
Date:1/7/2010

The laboratory of Dr. Frdric Charron, in Montreal, made this discovery

Montral, January 7, 2010 The laboratory of Dr. Frdric Charron, a researcher at the Institut de recherches cliniques de Montral (IRCM), has discovered a new molecular mechanism that permits the guidance of visual nerves towards the brain. Their findings have been published in the current issue of the Journal of Neuroscience. The research was conducted in collaboration with Dr. Tomomi Shimogori from the RIKEN Brain Science Institute, in Japan. Pierre Fabre, a doctoral student in Dr. Charron's research unit, is the article's first author.

To correctly establish nervous circuits, attractive and repulsive molecules are required to guide growing axons to their appropriate targets. One such molecule is Sonic Hedgehog (Shh). "Using genetic evidence and in utero manipulations in mice, we were able to demonstrate that the Sonic Hedgehog (Shh) molecular pathway is required for the guidance of retinal axons within the optic chiasm," specified Pierre Fabre. This guidance, which acts through repulsion, relies on the Boc receptor, which becomes therefore a prime target for the development of therapies that could stimulate axonal growth after injury or in neurodegenerative disorders.

Moreover, the authors have shed new light on the molecular mechanisms involved in the formation of the visual system. The optic chiasm is the crossroad of optic nerves stemming from both eyes and allows the brain to integrate binocular visual information, a crucial process for establishing 3D vision. "By showing that Boc and Shh play an important role in this neurobiological development process, we have identified a new molecular pathway required in the formation of the visual system," added Dr. Charron.

"CIHR is proud to support research such as Dr. Charron's, which will improve our understanding of visual development," says Dr. Anthony Phillips, Scientific Director of the Canadian Institutes of Health Research (CIHR) Institute of Neurosciences, Mental Health and Addiction. "The discovery of the new molecular mechanism will pave the way for research into neurodegenerative disorders and, eventually, treatment."


'/>"/>

Contact: Olivier Lagueux
olivier.lagueux@ircm.qc.ca
514-987-5555
Institut de recherches cliniques de Montreal
Source:Eurekalert

Related biology news :

1. New discovery by Harvard scientists aims to correct cellular defects leading to diabetes
2. New year, new vitamin C discovery: It cures mice with accelerated aging disease
3. Emerald BioStructures announces discovery of small molecule modulators of PDE4
4. UGA researchers lead team in discovery involving devastating freshwater fish parasite, Ich
5. Discovery makes brain tumor cells more responsive to radiation
6. Discovery of the Jekyll-and-Hyde factors in coral bleaching
7. Rocket science leads to new whale discovery
8. A year after discovery, Congos mother lode of gorillas remains vulnerable
9. Cancer metabolism discovery uncovers new role of IDH1 gene mutation in brain cancer
10. Its a gas: New discovery may lead to heartier, high-yielding plants
11. Discovery of new type of immune cells regulating inflammation in chronic diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/20/2017)... Delta (NYSE: DAL ) customers now can use ... Reagan Washington National Airport (DCA). ... Delta launches biometrics to board aircraft at Reagan Washington ... Delta,s biometric boarding pass experience that ... integrated into the boarding process to allow eligible Delta SkyMiles Members who ...
(Date:5/23/2017)... May 23, 2017  Hunova, the first robotic gym for the rehabilitation ... officially launched in Genoa, Italy . The first 30 ... and the USA . The technology was developed and ... by the IIT spin-off Movendo Technology thanks to a 10 million euro ... Release, please click: ...
(Date:4/24/2017)... -- Janice Kephart , former 9/11 Commission ... LLP (IdSP) , today issues the following statement: ... 6, 2017 Executive Order: Protecting the Nation ... instilled with greater confidence, enabling the reactivation of ... are suspended by until at least July 2017). ...
Breaking Biology News(10 mins):
(Date:10/7/2017)... ... October 06, 2017 , ... ... launched its ProxiMeta™ Hi-C metagenome deconvolution product, featuring the first commercially available ... bioinformatics software to perform Hi-C metagenome deconvolution using their own facilities, supplementing ...
(Date:10/6/2017)... (PRWEB) , ... October 06, 2017 , ... ... entrepreneurship within the healthcare and technology sector at their fourth annual Conference where ... featuring 30 inspiring speakers and the ELEVATE pitch competition showcasing early stage digital ...
(Date:10/5/2017)... , ... October 05, 2017 , ... LabRoots , ... scientists from around the world, is giving back to cancer research with a month-long ... , Now through October 31, shoppers can use promo code PinkRibbon to get ...
(Date:10/5/2017)... ... October 05, 2017 , ... NIH has awarded Circulomics ... Nanobind DNA/RNA extraction technology . Nanobind is a novel magnetic disk that contains ... can be used for a wide variety of sample preparation applications. The nanostructured ...
Breaking Biology Technology: