Navigation Links
Discovery of a new family of key mitochondrial proteins for the function and viability of the brain
Date:5/9/2012

A team headed by Eduardo Soriano at the Institute for Research in Biomedicine (IRB Barcelona) has published a study in Nature Communications describing a new family of six genes whose function regulates the movement and position of mitochondria in neurons. Many neurological conditions, including Parkinson's and various types of Charcot-Marie-Tooth disease, are caused by alterations of genes that control mitochondrial transport, a process that provides the energy required for cell function.

"We have identified a set of new genes that are highly expressed in the nervous system and have a specific function in a biological process that is crucial for the activity and viability of the nervous system", explains Eduardo Soriano, head of the Neurobiology and Cell Regeneration group at IRB Barcelona and full professor at the University of Barcelona (UB).

By means of comparative genomic analyses, the scientists have discovered that these genes are found only in more evolved mammals, the so-called Eutharia, these characterized by internal fertilization and development. "This finding indicates the relevance of mitochondrial biology. When the brain evolved in size, function and structure, the mitochondrial transport process also became more complex and probably required additional regulatory mechanisms", says Soriano. "Likewise, given the origin of the gene cluster, in the transition between primitive mammals, such as marsupials (kangaroos) and the remaining placental mammals, it is tempting to propose that the cluster is linked to the increased complexity of the cerebral cortex in the lineage that leads to humans", adds the full UB professor Jordi Garcia-Fernndez, collaborator in the study.

Correct brain function is highly energy-demanding. However, this energy must be finely distributed throughout neurons cells that have ramifications that can reach up to tens of centimetres in length, from the brain to the limbs. This cluster of genes forms part of the "wheel" machinery of mitochondria and regulates the localization of each cell on the basis of its energy requirements. "These genes would be like an extra control in cellular mitochondrial trafficking and they interact with the major proteins associated with the regulation of mitochondrial transport", explains Soriano.

Another striking characteristic of these new proteins is that they are found both in mitochondria, the function of which has already been described, and in the cell nucleus, where their function is unknown. "They may also be involved in the regulation of gene expression, a possibility that we are now studying". In addition to their potential involvement in brain pathologies, the researchers believe that these proteins may be related to metabolic diseases and cancer.


'/>"/>
Contact: Snia Armengou
sonia.armengou@irbbarcelona.org
34-934-037-255
Institute for Research in Biomedicine (IRB Barcelona)
Source:Eurekalert  

Related biology news :

1. Bacteria discovery could lead to antibiotics alternatives
2. Discovery reveals chromosomes organize into yarns
3. Stomata development in plants unraveled -- a valuable discovery for environmental research
4. New discovery may lead to effective prevention and treatment of graft-versus-host dsease
5. Tales from the crypt lead researchers to cancer discovery
6. Breast cancer risk gene discovery fast tracked by new technology
7. Discovery offers insight into treating viral stomach flu
8. Unexpected discovery reveals a new mechanism for how the cerebellum extracts signal from noise
9. Discovery provides blueprint for new drugs that can inhibit hepatitis C virus
10. Annual Drug Discovery Conferences Being Held in Boston MA, Spring 2012
11. Discovery of a molecule that initiates maturation of mammalian eggs can lead to more IVF pregnancies
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Discovery of a new family of key mitochondrial proteins for the function and viability of the brain
(Date:3/7/2017)... , March 7, 2017   HireVue , ... top global companies identify the best talent, faster, today ... Chief Sales Officer (CSO) and Diana Kucer ... round out a seasoned executive team poised to drive continued ... building on a year of record bookings in 2017. ...
(Date:3/2/2017)... 2017 Summary This report provides ... KGaA and its partnering interests and activities since 2010. ... Description The Partnering Deals and Alliance since 2010 report ... one of the world,s leading life sciences companies. ... to ensure inclusion of the most up to date ...
(Date:3/1/2017)... BEDFORD, Mass. , March 1, 2017  Aware, ... and services, announced that Richard P. Moberg ... Officer and co-President and Chief Financial Officer and Treasurer ... will continue to serve as a member of the ... T. Russell , Aware,s co-Chief Executive Officer and co-President, ...
Breaking Biology News(10 mins):
(Date:3/23/2017)... CT (PRWEB) , ... March 23, 2017 , ... ... LLC, was recently selected by the Connecticut Technology Council (CTC) as a 2017 ... at CTC’s thirteenth annual Women of Innovation Awards Dinner. , The dinner recognizes ...
(Date:3/23/2017)... 23, 2017  Agriculture technology company Cool Planet has ... note conversion to commercialize its Cool Terra and Cool ... developing products that are simultaneously profitable as well as ... last 18 months. This latest round of funding was ... The company,s primary product, Cool Terra, ...
(Date:3/22/2017)... ... March 22, 2017 , ... Researchers ... from small lab samples to full-size tissues, bones, even whole organs to implant ... system that delivers blood deep into the developing tissue. , Current bioengineering ...
(Date:3/22/2017)... , March 22, 2017 Oramed ... ( www.oramed.com ), a ... oral drug delivery systems, announced today that Dr. ... will deliver a presentation titled, "Oral Insulin for ... Cambridge Healthtech Institute,s Oligonucleotide and Peptide Therapeutics (OPT) ...
Breaking Biology Technology: