Navigation Links
Discovery of a mechanism that controls the expression of a protein involved in numerous cancers
Date:10/20/2010

This press release is available in French.

Researchers at the Institute for Research in Immunology and Cancer (IRIC) of the Universit de Montral have identified a new mechanism controlling the transmission of an abnormal signal at the origin of several cancers. In an article published in the journal Cell, Marc Therrien's team explains the recent discovery of a protein complex that controls the RAS/MAPK signalling pathway, responsible for some of the deadliest cancers, including pancreatic, colon and lung cancers, and melanomas. This regulating mechanism could prove to be a promising therapeutic target for the treatment of these diseases. The study conducted on the drosophila model organism is to be verified in humans in a forthcoming step.

Marc Therrien and his team focus their research on the RAS/MAPK signalling pathway, which is deregulated in several tumours. To send a message to the cell, the information must be relayed by proteins contained in this signalling pathway. In the case of the RAS/MAPK pathway, the message is given by RAS and the last protein in the pathway, MAPK, transmits the message to the cell's control centre, the nucleus. However, the RAS/MAPK pathway sometimes transmits erroneous messages which cause the cell to proliferate non-stop.

"Our study shows that a protein complex, EJC, controls production of the MAPK protein, which acts directly on the cell. When this complex is deficient, the signalling pathway is inhibited which restricts the chaotic proliferation of the cell at the origin of many cancers," Marc Therrien explains. "If we target EJC and the factors that regulate its activity, we could potentially prevent the transmission of abnormal signals that trigger several cancers."

In addition to serving as a promising therapeutic target for treating cancer, the regulating mechanism discovered for MAPK could also apply to several other genes. "Our research could serve to explain the production of other proteins with a behaviour similar to MAPK. This mechanism could help us to understand gene expression in general," Marc Therrien concludes.

The breakthrough was made possible by the SOLiD Next Generation Sequencing System manufactured by Life Technologies, which enabled the researchers to view the overall consequences of the elimination of EJC on the expression of all of the cell's genes. "IRIC has adopted a cutting-edge technological infrastructure, without which this kind of work would be impossible," explains Dr. Guy Sauvageau, Chief Executive Officer and Scientific Director of the IRIC. "The Life Technologies sequencing equipment allows us to perform cutting-edge research by quickly obtaining accurate and complete results."


'/>"/>

Contact: Carolyne Lord
carolyne.lord@umontreal.ca
514-343-7282
University of Montreal
Source:Eurekalert

Related biology news :

1. Chemical equator discovery will aid pollution mapping
2. Sirtris review of sirtuin therapeutics for diseases of aging in Nature Reviews Drug Discovery
3. Groundbreaking discovery may lead to stronger antibiotics
4. Discovery of natural compounds that could slow blood vessel growth
5. Nanoscopic screening process to speed drug discovery
6. FSU researchers discovery leads to $1.5 million grant, potential new treatment of liver fibrosis
7. New $11 million center to speed production of new compounds for drug discovery
8. Discovery of giant roaming deep sea protist provides new perspective on animal evolution
9. New discovery may enhance MRI scans, lead to portable MRI machines
10. Kidney function discovery sheds light on genetic complexity of disease
11. Discovery of new gene associated with diabetes risk suggests link with body clock
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/20/2016)... June 20, 2016 Securus Technologies, a ... solutions for public safety, investigation, corrections and monitoring ... involved, it has secured the final acceptance by ... for Managed Access Systems (MAS) installed. Furthermore, Securus ... to be installed by October, 2016. MAS distinguishes ...
(Date:6/9/2016)... , June 9, 2016 ... Police deploy Teleste,s video security solution to ensure the safety ... France during the major tournament Teleste, ... communications systems and services, announced today that its video security ... to back up public safety across the country. ...
(Date:6/2/2016)... --  The Weather Company , an IBM Business (NYSE: ... in which consumers will be able to interact with IBM ... voice or text and receive relevant information about the product ... have long sought an advertising solution that can create a ... and valuable; and can scale across millions of interactions and ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... SAN DIEGO , June 24, 2016 /PRNewswire/ ... that more sensitively detects cancers susceptible to PARP ... individual circulating tumor cells (CTCs). The new test ... of HRD-targeted therapeutics in multiple cancer types. ... therapies targeting DNA damage response pathways, including PARP, ...
(Date:6/23/2016)... 23, 2016   Boston Biomedical , an ... designed to target cancer stemness pathways, announced that ... Orphan Drug Designation from the U.S. Food and ... cancer, including gastroesophageal junction (GEJ) cancer. Napabucasin is ... inhibit cancer stemness pathways by targeting STAT3, and ...
(Date:6/23/2016)... Prostate Cancer Foundation (PCF) is pleased to announce 24 new Young Investigator ... Members of the Class of 2016 were selected from a pool of 128 ... About the Class of 2016 PCF Young Investigators ... ... ...
(Date:6/23/2016)... ... , ... In a new case report published today in STEM CELLS Translational ... lymphedema after being treated for breast cancer benefitted from an injection of stem cells ... this debilitating, frequent side effect of cancer treatment. , Lymphedema refers to ...
Breaking Biology Technology: