Navigation Links
Discovery of a 'conductor' in muscle development
Date:2/25/2014

Montral, February 25, 2014 A team led by Jean-Franois Ct, researcher at the IRCM, identified a ''conductor'' in the development of muscle tissue. The discovery, published online yesterday by the scientific journal Proceedings of the National Academy of Sciences (PNAS), could have an important impact on the treatment of muscular diseases such as myopathies and muscular dystrophies.

"For several years, we have been studying myogenesis, a process by which muscles are formed during embryonic development," says Jean-Franois Ct, PhD, Director of the Cytoskeletal Organization and Cell Migration research unit at the IRCM. "During the last step of this process, muscle cells called myoblasts align and fuse together to form muscle fibers."

The fusion of myoblasts is a critical step in the formation of embryonic muscle fibers as it determines muscle size, among other things. This process is also important in adult life because muscle stem cells fuse with existing fibers to achieve muscle growth and help regenerate damaged muscles. However, until now, fusion remained a poorly understood step within the scientific community.

"We were able to identify the receptor BAI3, a protein at the surface of myoblasts, as one of the crucial missing links in the fusion of muscle cells," adds Dr. Ct. "In fact, this receptor acts much like an orchestra conductor by activating a signalling pathway required for this important process."

In 2008, Dr. Ct's team explained the role of the DOCK1 and DOCK5 genes in the development of muscle tissue by showing that these two genes were critical regulators of the fusion process in mice. In their most recent study, the researchers confirmed receptor BAI3's essential role by blocking its interaction with the DOCK signalling pathway. They discovered that, as a result, myoblast fusion was also blocked.

"Our scientific breakthrough will undoubtedly have a translational research application on the regeneration of tissue from stem cells, given that a better understanding of the molecular mechanisms of fusion are required for the development of such therapies," concludes Dr. Ct. "This could therefore have an impact on the treatment of muscular diseases, including myopathies and muscular dystrophies."


'/>"/>

Contact: Julie Langelier
julie.langelier@ircm.qc.ca
514-987-5555
Institut de recherches cliniques de Montreal
Source:Eurekalert

Related biology news :

1. Discovery by Baylor University researchers sheds new light on the habitat of early apes
2. Graduate student makes major discovery about seal evolution
3. Quest for jellyfish robot leads to discovery of bending rules for animal wing, fin tips
4. €85 million for new way to carry out antibiotic drug discovery
5. Genetic discovery to keep crops disease-free
6. Discovery of quantum vibrations in microtubules corroborates theory of consciousness
7. Important discovery for the diagnosis of genetic diseases
8. New discovery could stimulate plant growth and increase crop yields, researchers say
9. Mutation discovery may improve treatment for rare brain tumor type
10. T2 and collaborators announce discovery of novel clot structure biology enabled by T2HemoStat
11. Discovery leads to patent for novel method of treating traumatic brain injury
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/9/2016)... 2016 This BCC Research report provides an ... RNA Sequencing (RNA Seq) market for the years 2015, ... and reagents, data analysis, and services. Use ... RNA-Sequencing market such as RNA-Sequencing tools and reagents, RNA-Sequencing ... affecting each segment and forecast their market growth, future ...
(Date:3/3/2016)... 3, 2016  FlexTech, a SEMI Strategic Association Partner, ... Research & Development, Leadership in Education, and, in a ... 9 th year of the FLEXI Awards and ... individuals from past years . Judging was done ... set of criteria, by a panel of non-affiliated, independent, ...
(Date:3/2/2016)... 2, 2016 http://www.researchandmarkets.com/research/cmt3hk/global_biometrics ... "Global Biometrics as a Service Market ... --> http://www.researchandmarkets.com/research/cmt3hk/global_biometrics ) has announced ... as a Service Market 2016-2020" report ... Research and Markets ( http://www.researchandmarkets.com/research/cmt3hk/global_biometrics ) has ...
Breaking Biology News(10 mins):
(Date:4/27/2016)... (PRWEB) , ... April 27, 2016 , ... ... (d/b/a Biohaven) is pleased to announce the appointment of John Tilton as Chief Commercial ... Executive Director and one of the founding commercial leaders responsible for the commercialization ...
(Date:4/27/2016)... ... ... Global Stem Cells Group CEO Benito Novas announced that Duncan Ross, ... Kimera Labs in Miami. , In 2004, Ross received his Ph.D. in Immunology from ... and the suppression of graft vs. host disease (GVHD) under UM Professor Robert Levy ...
(Date:4/26/2016)... ... April 27, 2016 , ... Cameron Cushman has ... associate in the firm’s Intellectual Property practice group. , Clients turn to Cushman ... He has an electrical engineering and computer engineering background, and experience in the ...
(Date:4/26/2016)... ... 26, 2016 , ... Mr. Palmer created the RPO business for Ceridian and ... multi-year managed services contract in the U.S. intelligence community with The SI (a Lockheed ... John Younger, founder of Accolo. “We are growing and his experience guiding our ...
Breaking Biology Technology: