Navigation Links
Discovery of DNA silencing mechanism reveals how plants protect their genome
Date:5/12/2011

Researchers at the RIKEN Plant Science Center (PSC) have clarified a key epigenetic mechanism by which an enzyme in the model plant Arabidopsis protects cells from harmful DNA elements. Published in the April 28th issue of the journal PLoS Genetics, the finding contributes to advancing our understanding of a broad range of biological processes in both plants and animals, opening the door to applications in cancer therapy and agriculture.

In everything from protein synthesis to gene expression to development, living cells depend critically for their survival on the successful functioning of their DNA. Certain DNA elements such as transposons, fragments of DNA that replicate within an organism's genome, can however disrupt this functioning and disable genes. To defend against such harmful elements, eukaryotic cells form inactive tightly-packed DNA called heterochromatin, whose dense structure serves to repress ("silence") the expression of nearby gene sequences and protect the genome.

Earlier research identified the enzyme HDA6 as playing a key role in such "hetrochromatin silencing" in the model plant Arabidopsis, but the mechanism involved remained unclear. In order to clarify this mechanism, the research group investigated the involvement of HDA6 in two processes: DNA methylation, an epigenetic modification that changes the structure of DNA without altering its sequence, and the modification of histone, the main component of chromatin.

Through a genome-wide comparison, the researchers were able to show that plants with repressed HDA6 function are not able to silence harmful DNA elements, suggesting that the enzyme plays an important role in gene silencing. Further investigation revealed that HDA6 binds directly to transposons and silences their activity through specific histone modifications, and that another enzyme, the DNA methyltransferase MET1, cooperates with HDA6 in this gene silencing.

Together, the fin
'/>"/>

Contact: Tomoko Ikawa
gro-pr@riken.jp
81-048-462-1225
RIKEN
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Serendipity leads to lifesaving discovery
2. Discovery demonstrates potential MS therapy could kill brain cells
3. Worm discovery could help 1 billion people worldwide
4. New discovery could green up hundreds of everyday products
5. Discovery identifies elaborate G-protein network in plants
6. A chance discovery may revolutionize hydrogen production
7. A world first: The discovery of a common genetic cause of autism and epilepsy
8. Discovery of protein that alters nutrition of breast cancer cells
9. Missouri Botanical Garden makes rare discovery of plant genus
10. Discovery of a biochemical basis for broccolis cancer-fighting ability
11. Discovery of source of glycogen manufacturing errors sheds light on fatal disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Discovery of DNA silencing mechanism reveals how plants protect their genome
(Date:12/17/2014)... BELVOIR, Va. , Dec. 15, 2014 /PRNewswire-USNewswire/ ... efforts to make it easier to detect and ... chain. Today the agency started performing ... The capability will validate the authenticity of purchased ... chain. The new quality control measures will be ...
(Date:12/15/2014)... 12, 2014 Research and Markets ... the "Global Facial Recognition Market 2015-2019" ... http://photos.prnewswire.com/prnh/20130307/600769 Facial recognition is ... Facial recognition system measures the overall facial feature ... mouth, and the distance between eyes. Facial recognition ...
(Date:12/10/2014)... NEW YORK , Dec. 8, 2014 You,ve ... online banking account but can,t remember your password, site key ... birthday? Who was your first grade teacher? ... launches the app that will finally put an ... PINs – 1U TM . 1U leverages a ...
Breaking Biology News(10 mins):Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 2Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 3Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 3The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 3
... January 19 Mexican business leader Carlos Slim Hel today ... medicine that will help accelerate progress in public health in ... carried out by the Carlos Slim Institute of Health in ... the National Institute for Genomic Medicine of the Mexican Secretariat ...
... is "Molecule of the Year 2009". This was announced ... Society for Molecular and Cell Biology and Biotechnology Protocols ... Zsuzsanna Izsvk, Dr. Zoltn Ivics and Dr. Lajos Mts ... Berlin-Buch. According to the jury, it was selected out ...
... a specific form of a gene that puts them on ... of cancer, according to a new study by scientists at ... proto-oncogene is activated in a variety of tumor malignancies. The ... a role in neurodevelopment, which is why Katherine E. Burdick, ...
Cached Biology News:Mexico-US collaboration launched to study major human diseases 2'Sleeping Beauty' -- Molecule of the Year 2Gene linked to schizophrenia may reduce cancer risk 2
(Date:12/17/2014)... (PRWEB) December 17, 2014 Gene ... that it has entered into a technology access ... (ADM) to apply DNA2.0’s proprietary protein engineering technology, ... process. , “We are extremely excited that the ... platform. This proprietary bioengineering technology has now ...
(Date:12/17/2014)... SOUTH SAN FRANCISCO, Calif. , Dec. 17, ... positive results of a Phase 2 study evaluating ... for the treatment of patients with severe, chronic ... the current standard of care, including topical steroids ... endpoint was percent change in Visual Analog Scale ...
(Date:12/15/2014)...  GlassesOff Inc. (OTCBB: GLSO) announced today the appointment ... director of the Company,s Board of Directors. ... its CEO until its acquisition by Stanley Black ... Recognized as the inventor of the first Wi-Fi-based Active ... -based RFID solutions focused on improving operational efficiency, safety ...
(Date:12/13/2014)... (PRWEB) December 12, 2014 Clarassance, a ... announced its new name: Therabron Therapeutics , Inc. ... and bronchioles (a type of structure in the lungs ... company’s mission to develop novel protein therapeutics for the ... directors decided to change the name to mark the ...
Breaking Biology Technology:ADM and DNA2.0 Enter Into Protein Engineering Technology Access and Service Agreement 2Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 2Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 3Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 4AeroScout Founder Joins GlassesOff's Board of Directors 2AeroScout Founder Joins GlassesOff's Board of Directors 3Maryland-based Biotech Company's Path Forward in Treating Respiratory Diseases Sparks Name Change 2
... EXTON, Pa., June 2 ViroPharma Incorporated (Nasdaq: ... and chief scientific officer of ViroPharma, will present at the ... ET on Tuesday, June 9, 2009. The conference is ... , , ViroPharma also announced that William Roberts, vice ...
... College Troy campus ... , TROY, Mich., June 2 Walsh College ... to offer a new series of Walsh College,s successful "Take Charge" workshops for ... days, more topics and expanded career content. All are provided at no ...
... 2 Cynosure, Inc. (Nasdaq: CYNO ... aesthetic treatment systems, today announced that President and Chief Executive Officer Michael ... the following investor conferences in New York City this month: , ... Gabelli & Company Healthcare Symposium , Tuesday, June 9; ...
Cached Biology Technology:ViroPharma to Present at Two June Healthcare Conferences 2Walsh College and Ford Motor Company Fund and Community Services Team Up To Offer New Series of 'Take Charge' Workshops for the Unemployed 2Walsh College and Ford Motor Company Fund and Community Services Team Up To Offer New Series of 'Take Charge' Workshops for the Unemployed 3Walsh College and Ford Motor Company Fund and Community Services Team Up To Offer New Series of 'Take Charge' Workshops for the Unemployed 4Cynosure Announces Presentations at Upcoming Investor Conferences 2
... EPS 3501 XL Power Supply, 1. 3500 ... constant current, constant power, and linear voltage ... to focused equilibrium in IPG strips quickly ... compensate for variations in gel thickness, sample ...
...
Request Info...
... ESGRO Complete Derivation Kit is intended ... cells from delayed blastocysts in serum-free ... Clonal Grade ... Blastocyst Incubation Medium Trypsin Solution ...
Biology Products: