Navigation Links
Discovery of DNA silencing mechanism reveals how plants protect their genome
Date:5/12/2011

Researchers at the RIKEN Plant Science Center (PSC) have clarified a key epigenetic mechanism by which an enzyme in the model plant Arabidopsis protects cells from harmful DNA elements. Published in the April 28th issue of the journal PLoS Genetics, the finding contributes to advancing our understanding of a broad range of biological processes in both plants and animals, opening the door to applications in cancer therapy and agriculture.

In everything from protein synthesis to gene expression to development, living cells depend critically for their survival on the successful functioning of their DNA. Certain DNA elements such as transposons, fragments of DNA that replicate within an organism's genome, can however disrupt this functioning and disable genes. To defend against such harmful elements, eukaryotic cells form inactive tightly-packed DNA called heterochromatin, whose dense structure serves to repress ("silence") the expression of nearby gene sequences and protect the genome.

Earlier research identified the enzyme HDA6 as playing a key role in such "hetrochromatin silencing" in the model plant Arabidopsis, but the mechanism involved remained unclear. In order to clarify this mechanism, the research group investigated the involvement of HDA6 in two processes: DNA methylation, an epigenetic modification that changes the structure of DNA without altering its sequence, and the modification of histone, the main component of chromatin.

Through a genome-wide comparison, the researchers were able to show that plants with repressed HDA6 function are not able to silence harmful DNA elements, suggesting that the enzyme plays an important role in gene silencing. Further investigation revealed that HDA6 binds directly to transposons and silences their activity through specific histone modifications, and that another enzyme, the DNA methyltransferase MET1, cooperates with HDA6 in this gene silencing.

Together, the fin
'/>"/>

Contact: Tomoko Ikawa
gro-pr@riken.jp
81-048-462-1225
RIKEN
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Serendipity leads to lifesaving discovery
2. Discovery demonstrates potential MS therapy could kill brain cells
3. Worm discovery could help 1 billion people worldwide
4. New discovery could green up hundreds of everyday products
5. Discovery identifies elaborate G-protein network in plants
6. A chance discovery may revolutionize hydrogen production
7. A world first: The discovery of a common genetic cause of autism and epilepsy
8. Discovery of protein that alters nutrition of breast cancer cells
9. Missouri Botanical Garden makes rare discovery of plant genus
10. Discovery of a biochemical basis for broccolis cancer-fighting ability
11. Discovery of source of glycogen manufacturing errors sheds light on fatal disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Discovery of DNA silencing mechanism reveals how plants protect their genome
(Date:8/27/2014)... PITTSBURGHLearning a new skill is easier when it is ... a trained pianist might learn a new melody more ... , Neural engineers from the Center for the Neural ... of Pittsburgh and Carnegie Mellon Universityhave discovered a fundamental ... happens. Published as the cover story in the Aug. ...
(Date:8/27/2014)... greatest risk to Europe based upon a proxy for ... using a ,big data, approach to scientific research. , ... Global Health ranked the top 100 pathogens affecting humans ... system which, they believe, will help governments across the ... infectious diseases, including as a result of climate change, ...
(Date:8/27/2014)... that exists as five strains, none of which have ... the Sudan ebolavirus (SUDV). Although not the strain currently ... as recently as 2012. In a new study appearing ... now report a possible therapy that could someday help ... Sidhu, Jonathan Lai and colleagues explain that about 50-90 ...
Breaking Biology News(10 mins):Pitt and Carnegie Mellon engineers discover why learning can be difficult 2Pitt and Carnegie Mellon engineers discover why learning can be difficult 3Big data approach identifies Europe's most dangerous human and domestic animal pathogens 2Potential therapy for the Sudan strain of Ebola could help contain some future outbreaks 2
... of Princeton biologists and engineers has dramatically improved the speed ... influences almost every aspect of how cells and tissues function. ... cells, cancer and other problems of fundamental importance to biology ... look at a special class of proteins called histones, which ...
... National Institute of Environmental Health Sciences (NIEHS), part of ... in understanding the potential health, safety and environmental issues ... everyday products such as sunscreens, cosmetics and electronics. The ... period, through the American Recovery and Reinvestment Act, to ...
... saliva to tell whether those stiff joints, memory lapses, and ... for disease, scientists are describing how the protein content of ... to a simple, noninvasive test for better diagnosing and treating ... in ACS, Journal of Proteome Research , a monthly ...
Cached Biology News:Beyond genomics, biologists and engineers decode the next frontier 2Beyond genomics, biologists and engineers decode the next frontier 3NIEHS awards Recovery Act funds to focus more research on health and safety of nanomaterials 2NIEHS awards Recovery Act funds to focus more research on health and safety of nanomaterials 3NIEHS awards Recovery Act funds to focus more research on health and safety of nanomaterials 4
(Date:8/27/2014)... Research and Markets  has announced ... (Biodegradable Polymer, Food & Beverage, Personal Care & ... report to their offering. Lactic ... asymmetrical carbon atom. The main applications of lactic ... beverage, personal care product, and pharmaceutical industries. ...
(Date:8/27/2014)... , Aug. 27, 2014 Guggenheim Securities, the ... today announced the hiring of veteran equity analyst Charles ... analyst. Mr. Butler will focus on the biotech/biopharma sector. ... a wealth of experience and a broad network of ... Senior Managing Director and Head of Equities at Guggenheim ...
(Date:8/27/2014)... , Aug. 27, 2014 Research ... "Global Stable Isotope Ratio Mass Spectrometer Industry Report 2014" ... Global Stable Isotope Ratio Mass Spectrometer Industry Report 2014 ... state of the global isotope ratio mass spectrometer industry. ... the industry including definitions, classifications, applications and industry chain ...
(Date:8/27/2014)... (PRWEB) August 27, 2014 BIOEQUA, an ... through the use of a handheld spray, has made ... United States. , The brand began with an ... researchers were surprised to learn that the application of ... extremely small and delivered directly to skin's basal layer. ...
Breaking Biology Technology:Global Lactic Acid (Biodegradable Polymer, Food & Beverage, Personal Care & Pharmaceutical) Market - Trends & Forecasts to 2019 2Guggenheim Securities Hires Analyst Charles "Tony" Butler to Expand Healthcare Coverage 2Global Stable Isotope Ratio Mass Spectrometer Industry Report 2014 2BIOEQUA'S EQUA ESSENTIAL Product Line Redefines Skin Care & Now Available in America 2
... Isolation Kit , Catalog #732-6370 , ... Cell Lysis , 1. Vigorously add ... (or other tube rated for high speed) containing 500 l body fluid , ... whole blood). , 2. Vortex for 5 sec to mix thoroughly. , ...
... , Patrick M. Gaffney, Elizabeth A. Orbacz, and Ziniu Yu, ... University of Delaware, Lewes, Delaware., , ... DNA polymorphisms are useful tools for ecological and evolutionary ... with applications ranging from , species identification to ...
... Amutan and David Batey, Ph.D., , ... Real-time quantification was performed for lambda and ... DyNAzyme II DNA polymerase*,was used for amplification, and SYBR Green I fluorescent dye ... was tested for ranges,of 100 to 1x10 8 initial copies of lambda ...
Cached Biology Technology:Total RNA Isolation From 500 l Body Fluid 2Using the DCode System to Identify DNA Sequence Variation for Studies of Population Structure in Marine Organisms 2Using the DCode System to Identify DNA Sequence Variation for Studies of Population Structure in Marine Organisms 3Using the DCode System to Identify DNA Sequence Variation for Studies of Population Structure in Marine Organisms 4Using the DCode System to Identify DNA Sequence Variation for Studies of Population Structure in Marine Organisms 5Using the DCode System to Identify DNA Sequence Variation for Studies of Population Structure in Marine Organisms 6Using the DCode System to Identify DNA Sequence Variation for Studies of Population Structure in Marine Organisms 7Using the DCode System to Identify DNA Sequence Variation for Studies of Population Structure in Marine Organisms 8Real-Time Quantification of Genomic DNA Using DyNAzyme II DNA Polymerase and SYBR Green I Dye 2Real-Time Quantification of Genomic DNA Using DyNAzyme II DNA Polymerase and SYBR Green I Dye 3Real-Time Quantification of Genomic DNA Using DyNAzyme II DNA Polymerase and SYBR Green I Dye 4Real-Time Quantification of Genomic DNA Using DyNAzyme II DNA Polymerase and SYBR Green I Dye 5Real-Time Quantification of Genomic DNA Using DyNAzyme II DNA Polymerase and SYBR Green I Dye 6Real-Time Quantification of Genomic DNA Using DyNAzyme II DNA Polymerase and SYBR Green I Dye 7Real-Time Quantification of Genomic DNA Using DyNAzyme II DNA Polymerase and SYBR Green I Dye 8
... interface. All the functionality of the micro1401 ... memory and more available channels of waveform ... an option for programmable front-end gain. Can ... 48 waveform inputs and from 4 to ...
... reagent is used to inhibit ... fluorescence microscopy. The unique formulation ... wide variety of fixed specimens ... rhodamine, sulforhodamine 101, coumarin, DAPI, ...
Anti-Conjugated Quinaldic Acid...
... and 96 well plates. microCLEAN is an extremely ... half spin DNA cleanup reagent. It can be ... of double stranded DNA, efficiently removing reaction buffers, ... unlabelled). It is therefore ideally suited to clean ...
Biology Products: