Navigation Links
Discovery of DNA silencing mechanism reveals how plants protect their genome
Date:5/12/2011

Researchers at the RIKEN Plant Science Center (PSC) have clarified a key epigenetic mechanism by which an enzyme in the model plant Arabidopsis protects cells from harmful DNA elements. Published in the April 28th issue of the journal PLoS Genetics, the finding contributes to advancing our understanding of a broad range of biological processes in both plants and animals, opening the door to applications in cancer therapy and agriculture.

In everything from protein synthesis to gene expression to development, living cells depend critically for their survival on the successful functioning of their DNA. Certain DNA elements such as transposons, fragments of DNA that replicate within an organism's genome, can however disrupt this functioning and disable genes. To defend against such harmful elements, eukaryotic cells form inactive tightly-packed DNA called heterochromatin, whose dense structure serves to repress ("silence") the expression of nearby gene sequences and protect the genome.

Earlier research identified the enzyme HDA6 as playing a key role in such "hetrochromatin silencing" in the model plant Arabidopsis, but the mechanism involved remained unclear. In order to clarify this mechanism, the research group investigated the involvement of HDA6 in two processes: DNA methylation, an epigenetic modification that changes the structure of DNA without altering its sequence, and the modification of histone, the main component of chromatin.

Through a genome-wide comparison, the researchers were able to show that plants with repressed HDA6 function are not able to silence harmful DNA elements, suggesting that the enzyme plays an important role in gene silencing. Further investigation revealed that HDA6 binds directly to transposons and silences their activity through specific histone modifications, and that another enzyme, the DNA methyltransferase MET1, cooperates with HDA6 in this gene silencing.

Together, the findings establish for the first time that MET1-mediated DNA methylation and HDA6-mediated histone modification work together in repressing harmful DNA elements. By shedding light on the complex interplay between these two processes, the findings provide valuable insight on how plants and animals have evolved to protect their genome from harmful DNA, contributing to applications in areas such as cancer therapy and agriculture.


'/>"/>

Contact: Tomoko Ikawa
gro-pr@riken.jp
81-048-462-1225
RIKEN
Source:Eurekalert  

Related biology news :

1. Serendipity leads to lifesaving discovery
2. Discovery demonstrates potential MS therapy could kill brain cells
3. Worm discovery could help 1 billion people worldwide
4. New discovery could green up hundreds of everyday products
5. Discovery identifies elaborate G-protein network in plants
6. A chance discovery may revolutionize hydrogen production
7. A world first: The discovery of a common genetic cause of autism and epilepsy
8. Discovery of protein that alters nutrition of breast cancer cells
9. Missouri Botanical Garden makes rare discovery of plant genus
10. Discovery of a biochemical basis for broccolis cancer-fighting ability
11. Discovery of source of glycogen manufacturing errors sheds light on fatal disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Discovery of DNA silencing mechanism reveals how plants protect their genome
(Date:6/2/2016)... The Department of Transport Management (DOTM) ... million US Dollar project, for the , Supply ... Enrolment, and IT Infrastructure , to ... implementation of Identity Management Solutions. Numerous renowned international vendors participated ... was selected for the most compliant and innovative ...
(Date:5/24/2016)... IRVINE, Calif. , May 24, 2016 Ampronix facilitates superior patient care ... LMD3251MT  3D medical LCD display is the latest premium product recently added to ... ... ... Sony 3d Imaging- LCD Medical Display- Ampronix News ...
(Date:5/9/2016)... Elevay is currently known as ... for high net worth professionals seeking travel for work ... world, there is still no substitute for a face-to-face ... your deal with a firm handshake. This is why ... of citizenship via investment programs like those offered by ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... CLEVELAND , June 27, 2016  Global ... average 4.6 percent through 2020 to $7.2 billion.  ... (food and beverages, cleaning products, biofuel production, animal ... and biotechnology, diagnostics, and biocatalysts). Food and beverages ... gains driven by increasing consumption of products containing ...
(Date:6/27/2016)... ... June 27, 2016 , ... Newly ... technologies, services and solutions to the healthcare market. The company's primary focus is ... manufacturing, sales and marketing strategies that are necessary to help companies efficiently bring ...
(Date:6/24/2016)... 2016 Epic Sciences unveiled a liquid ... to PARP inhibitors by targeting homologous recombination deficiency ... new test has already been incorporated into numerous ... types. Over 230 clinical trials are ... including PARP, ATM, ATR, DNA-PK and WEE-1. Drugs ...
(Date:6/23/2016)... CAMBRIDGE, Mass. , June 23, 2016 /PRNewswire/ ... the development of novel compounds designed to target ... compound, napabucasin, has been granted Orphan Drug Designation ... in the treatment of gastric cancer, including gastroesophageal ... cancer stemness inhibitor designed to inhibit cancer stemness ...
Breaking Biology Technology: