Navigation Links
Discovery may provide new treatments for alcohol dependence
Date:6/30/2009

Researchers at the Sahlgrenska Academy, University of Gothenburg, Sweden, have discovered a new brain mechanism involved in alcohol addiction involving the stomach hormone ghrelin. When ghrelin's actions in the brain are blocked, alcohol's effects on the reward system are reduced. It is an important discovery that could lead to new therapies for addictions such as alcohol dependence.

The results will be published in the renowned American scientific journal Proceedings of the National Academy of Sciences (PNAS).

Ghrelin is a hormone produced by the stomach and, by signalling in the brain, increases hunger. The new finding, that it is also involved in alcohol addiction, highlights the reward system of the brain as a key target for ghrelin's effects. "Ghrelin's actions in the brain may be of importance for all kinds of addictions, including chemical drugs such as alcohol and even food" says Suzanne Dickson, Professor of Physiology, a leading expert in appetite regulation.

The work emerged from a unique collaboration between the research groups of Prof Suzanne Dickson and Prof Emeritus Jrgen Engel, including researchers Dr Elisabet Jerlhag and Dr Emil Egecioglu. They show that mice treated with ghrelin increase their alcohol consumption. When ghrelin's actions are blocked, for example, by administering ghrelin receptor antagonists, mice no longer show preference for an alcohol-associated environment -in other words, alcohol is no longer able to produce its addictive effects, that include reward searching behaviour (akin to craving in alcoholic patients). "If we can develop drugs that block the receptors for ghrelin, we could have a new effective treatment for alcohol dependence. It may however take several years until such a pharmacological treatment will reach the patient", says Professor Emeritus Jrgen Engel, an authority on research on alcohol dependency at the Sahlgrenska Academy. The group has submitted a patent application for this invention.


'/>"/>

Contact: Elin Lindstrm Claessen
elin.lindstrom@sahlgrenska.gu.se
46-031-786-3869
University of Gothenburg
Source:Eurekalert  

Related biology news :

1. Discovery may help defang viruses
2. Stomach stem cell discovery could bring cancer insights
3. Symposium marks 30th anniversary of discovery of third domain of life
4. Emory paleontologist reports discovery of carnivorous dinosaur tracks in Australia
5. Natural product discovery by Cleveland medical researchers blocks tissue destruction
6. Researchers discovery may lead to hypertension treatment
7. Yale discovery suggests protein may play a role in severe asthma
8. Galapagos and Cystic Fibrosis Foundation Therapeutics announce drug discovery collaboration
9. Profound immune system discovery opens door to halting destruction of lupus
10. Scripps Research discovery leads to broad potential applications in CovX-Pfizer deal
11. New discovery could reduce the health risk of high-fat foods
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Discovery may provide new treatments for alcohol dependence
(Date:4/26/2016)... 2016 Research and Markets has ... Market 2016-2020"  report to their offering.  , ,     ... The analysts forecast the global multimodal biometrics market ... the period 2016-2020.  Multimodal biometrics is ... as the healthcare, BFSI, transportation, automotive, and government ...
(Date:4/15/2016)... 15, 2016  A new partnership announced today ... underwriting decisions in a fraction of the time ... and high-value life insurance policies to consumers without ... With Force Diagnostics, rapid testing (A1C, Cotinine and ... (blood pressure, weight, pulse, BMI, and activity data) ...
(Date:4/14/2016)... April 14, 2016 BioCatch ... Detection, today announced the appointment of Eyal Goldwerger ... role. Goldwerger,s leadership appointment comes at a ... of the deployment of its platform at several of ... technology, which discerns unique cognitive and physiological factors, is ...
Breaking Biology News(10 mins):
(Date:6/27/2016)...  Liquid Biotech USA , ... Sponsored Research Agreement with The University of Pennsylvania ... cancer patients.  The funding will be used to ... clinical outcomes in cancer patients undergoing a variety ... employed to support the design of a therapeutic, ...
(Date:6/24/2016)... discussions on a range of subjects including policies, debt and ... Poloz. Speaking at a lecture to the Canadian ... to the country,s inflation target, which is set by both ... "In certain areas there needs to be ... why not sit down and address strategy together?" ...
(Date:6/24/2016)... ... 24, 2016 , ... While the majority of commercial spectrophotometers and fluorometers use ... 6000i models are higher end machines that use the more unconventional z-dimension of 20mm. ... from the bottom of the cuvette holder. , FireflySci has developed several Agilent ...
(Date:6/23/2016)... WA (PRWEB) , ... June 23, 2016 , ... ... announces the release of its second eBook, “Clinical Trials Patient Recruitment and Retention ... recruitment and retention in this eBook by providing practical tips, tools, and strategies ...
Breaking Biology Technology: