Navigation Links
Discovery may provide new treatments for alcohol dependence
Date:6/30/2009

Researchers at the Sahlgrenska Academy, University of Gothenburg, Sweden, have discovered a new brain mechanism involved in alcohol addiction involving the stomach hormone ghrelin. When ghrelin's actions in the brain are blocked, alcohol's effects on the reward system are reduced. It is an important discovery that could lead to new therapies for addictions such as alcohol dependence.

The results will be published in the renowned American scientific journal Proceedings of the National Academy of Sciences (PNAS).

Ghrelin is a hormone produced by the stomach and, by signalling in the brain, increases hunger. The new finding, that it is also involved in alcohol addiction, highlights the reward system of the brain as a key target for ghrelin's effects. "Ghrelin's actions in the brain may be of importance for all kinds of addictions, including chemical drugs such as alcohol and even food" says Suzanne Dickson, Professor of Physiology, a leading expert in appetite regulation.

The work emerged from a unique collaboration between the research groups of Prof Suzanne Dickson and Prof Emeritus Jrgen Engel, including researchers Dr Elisabet Jerlhag and Dr Emil Egecioglu. They show that mice treated with ghrelin increase their alcohol consumption. When ghrelin's actions are blocked, for example, by administering ghrelin receptor antagonists, mice no longer show preference for an alcohol-associated environment -in other words, alcohol is no longer able to produce its addictive effects, that include reward searching behaviour (akin to craving in alcoholic patients). "If we can develop drugs that block the receptors for ghrelin, we could have a new effective treatment for alcohol dependence. It may however take several years until such a pharmacological treatment will reach the patient", says Professor Emeritus Jrgen Engel, an authority on research on alcohol dependency at the Sahlgrenska Academy. The group has submitted a patent application for this invention.


'/>"/>

Contact: Elin Lindstrm Claessen
elin.lindstrom@sahlgrenska.gu.se
46-031-786-3869
University of Gothenburg
Source:Eurekalert  

Related biology news :

1. Discovery may help defang viruses
2. Stomach stem cell discovery could bring cancer insights
3. Symposium marks 30th anniversary of discovery of third domain of life
4. Emory paleontologist reports discovery of carnivorous dinosaur tracks in Australia
5. Natural product discovery by Cleveland medical researchers blocks tissue destruction
6. Researchers discovery may lead to hypertension treatment
7. Yale discovery suggests protein may play a role in severe asthma
8. Galapagos and Cystic Fibrosis Foundation Therapeutics announce drug discovery collaboration
9. Profound immune system discovery opens door to halting destruction of lupus
10. Scripps Research discovery leads to broad potential applications in CovX-Pfizer deal
11. New discovery could reduce the health risk of high-fat foods
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Discovery may provide new treatments for alcohol dependence
(Date:6/15/2016)... June 15, 2016 Transparency ... titled "Gesture Recognition Market by Application Market - Global Industry Analysis ... 2024". According to the report, the  global gesture recognition ... 2015 and is estimated to grow at a ... by 2024.  Increasing application of gesture ...
(Date:6/9/2016)... TURKU, Finland , June 9, 2016 ... French National Police deploy Teleste,s video security solution to ensure ... France during the major tournament ... and data communications systems and services, announced today that its ... Police Prefecture to back up public safety across ...
(Date:6/3/2016)... 2016 Das DOTM ... Nepal hat ein 44 Millionen ... Kennzeichen, einschließlich Personalisierung, Registrierung und IT-Infrastruktur, an ... und Implementierung von Identitätsmanagementlösungen. Zahlreiche renommierte internationale ... teilgenommen, aber Decatur wurde als konformste und ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... MA (PRWEB) , ... June 23, 2016 , ... ... Peel Plate® YM (Yeast and Mold) microbial test has received AOAC Research Institute ... platform of microbial tests introduced last year,” stated Bob Salter, Vice President of ...
(Date:6/23/2016)... -- The Biodesign Challenge (BDC), a university competition that asks ... systems and biotechnology, announced its winning teams at the ... York City . The teams, chosen ... MoMA,s Celeste Bartos Theater during the daylong summit. Keynote ... of architecture and design, and Suzanne Lee , ...
(Date:6/23/2016)... ... , ... Supplyframe, the Industry Network for electronics hardware design ... Located in Pasadena, Calif., the Design Lab’s mission is to bring together inventors ... and brought to market. , The Design Lab is Supplyframe’s physical representation of ...
(Date:6/23/2016)... ... June 23, 2016 , ... In a new case report ... detail how a patient who developed lymphedema after being treated for breast cancer benefitted ... change the paradigm for dealing with this debilitating, frequent side effect of cancer treatment. ...
Breaking Biology Technology: