Navigation Links
Discovery may provide new treatments for alcohol dependence
Date:6/30/2009

Researchers at the Sahlgrenska Academy, University of Gothenburg, Sweden, have discovered a new brain mechanism involved in alcohol addiction involving the stomach hormone ghrelin. When ghrelin's actions in the brain are blocked, alcohol's effects on the reward system are reduced. It is an important discovery that could lead to new therapies for addictions such as alcohol dependence.

The results will be published in the renowned American scientific journal Proceedings of the National Academy of Sciences (PNAS).

Ghrelin is a hormone produced by the stomach and, by signalling in the brain, increases hunger. The new finding, that it is also involved in alcohol addiction, highlights the reward system of the brain as a key target for ghrelin's effects. "Ghrelin's actions in the brain may be of importance for all kinds of addictions, including chemical drugs such as alcohol and even food" says Suzanne Dickson, Professor of Physiology, a leading expert in appetite regulation.

The work emerged from a unique collaboration between the research groups of Prof Suzanne Dickson and Prof Emeritus Jrgen Engel, including researchers Dr Elisabet Jerlhag and Dr Emil Egecioglu. They show that mice treated with ghrelin increase their alcohol consumption. When ghrelin's actions are blocked, for example, by administering ghrelin receptor antagonists, mice no longer show preference for an alcohol-associated environment -in other words, alcohol is no longer able to produce its addictive effects, that include reward searching behaviour (akin to craving in alcoholic patients). "If we can develop drugs that block the receptors for ghrelin, we could have a new effective treatment for alcohol dependence. It may however take several years until such a pharmacological treatment will reach the patient", says Professor Emeritus Jrgen Engel, an authority on research on alcohol dependency at the Sahlgrenska Academy. The group has submitted a patent app
'/>"/>

Contact: Elin Lindstrm Claessen
elin.lindstrom@sahlgrenska.gu.se
46-031-786-3869
University of Gothenburg
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Discovery may help defang viruses
2. Stomach stem cell discovery could bring cancer insights
3. Symposium marks 30th anniversary of discovery of third domain of life
4. Emory paleontologist reports discovery of carnivorous dinosaur tracks in Australia
5. Natural product discovery by Cleveland medical researchers blocks tissue destruction
6. Researchers discovery may lead to hypertension treatment
7. Yale discovery suggests protein may play a role in severe asthma
8. Galapagos and Cystic Fibrosis Foundation Therapeutics announce drug discovery collaboration
9. Profound immune system discovery opens door to halting destruction of lupus
10. Scripps Research discovery leads to broad potential applications in CovX-Pfizer deal
11. New discovery could reduce the health risk of high-fat foods
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Discovery may provide new treatments for alcohol dependence
(Date:10/15/2014)... The Ebola virus is spreading rapidly and to an ... experienced in the past and the virus shows a ... been recorded before. For this reason, the German National ... of Science and Engineering, and the Union of the ... statement on the Ebola epidemic today. , In the ...
(Date:10/15/2014)... 44th Rosenstiel Award for Distinguished Work in Biomedical Science ... mechanisms of genomic instability and its implications for the ... alumnus to win the Rosenstiel Award; the first, Rod ... is the Charles A. Janeway Professor of Pediatrics and ... investigator at the Howard Hughes Medical Institute at Boston ...
(Date:10/14/2014)... Cancer Research shows SIRT6—a protein known to inhibit ... development of skin cancers by turning on an enzyme ... cells. , Previously considered protective, SIRT6 is part of ... regulate genomic stability and prevent some of the genetic ... which can lead to cancer. This study, in the ...
Breaking Biology News(10 mins):Academies call for consequences from the Ebola virus epidemic 2Academies call for consequences from the Ebola virus epidemic 3Academies call for consequences from the Ebola virus epidemic 4Academies call for consequences from the Ebola virus epidemic 5Brandeis awards 44th Rosenstiel Award to pioneering geneticist Fred Alt 2Two-faced gene: SIRT6 prevents some cancers but promotes sun-induced skin cancer 2
... World leaders have made pitiful progress on their guarantee to ... a paper published today (Friday 15th June) in Science ... researchers have reviewed commitments made by governments to protect the ... over the past 20 years. At the World ...
... found a surprising connection between a key DNA-repair process and ... and other chronic conditions. The discovery promises to open up ... could ultimately yield novel treatments for a wide variety of ... it goes against current dogma about the role of DNA ...
... the Instituto Andaluz de Ciencias de la Tierra and other ... published in the prestigious journal Reviews of Modern Physics ... different countries has published the most comprehensive study ever done ... important contemporary issues in a field of research that is ...
Cached Biology News:A sea of broken promises 2Scientists tie DNA repair to key cell signaling network 2Spanish scientist participate in the most comprehensive study ever done on ice 2
(Date:10/22/2014)... Involution Studios , a healthcare ... new infographic, Understanding Ebola . The goal ... easy to follow informative tool for anyone wanting to ... and prevention. , "As the news has spread in ... outbreak represents not only a healthcare crisis with global ...
(Date:10/22/2014)... Currently offering a comprehensive portfolio ... Weighing, Rice Lake, and Ohaus, Pipette.com has added ... Sartorius CPA Semi-Micro Balance is ideal for lab ... user-friendly laboratory balance. , Sartorius is a global ... balances are well known for their high performance, ...
(Date:10/22/2014)... 2014 Physicians Choice Laboratory Services ... menu, which enables healthcare providers to individualize therapeutic ... evidence-based results, healthcare providers are better able to ... while minimizing risks for adverse drug reactions and ... the FDA [1] more than 2.2 million adverse ...
(Date:10/22/2014)... --  Synthetic Biologics, Inc. (NYSE MKT: SYN), a ... and diseases, announced today that the U.S. Patent and ... a composition of matter patent application that covers the ... This is Synthetic Biologics, first allowed patent application directly ... the Company,s extensive C. difficile patent estate. ...
Breaking Biology Technology:Involution Studios' Ebola Infographic Provides Key Disease Information and Statistics at a Glance 2Pipette.com Launches the Addition of Sartorius CPA Semi-Micro Balance to Their Product Portfolio with Special Promotional Pricing 2Pipette.com Launches the Addition of Sartorius CPA Semi-Micro Balance to Their Product Portfolio with Special Promotional Pricing 3PCLS Announces Expansion of Cardiovascular Pharmacogenetic Testing Menu 2PCLS Announces Expansion of Cardiovascular Pharmacogenetic Testing Menu 3Synthetic Biologics Announces Allowance of Key U.S. Composition of Matter Patent for C. difficile Program 2Synthetic Biologics Announces Allowance of Key U.S. Composition of Matter Patent for C. difficile Program 3Synthetic Biologics Announces Allowance of Key U.S. Composition of Matter Patent for C. difficile Program 4
... On June 19 and 20 at the Drake Hotel ... real estate, legal, engineering and due diligence providers gathered ... on the small and middle markets ($10 million to ... such as "maximizing the value of your brand and ...
... Madison, Wis . - In a merging of complementary companies, ... new Vitamin D products, has acquired Proventiv Therapeutics, LLC, of ... $25 million in venture capital from Canadian and American investors. ... of Bone Care International , which was acquired last ...
... and natural gas have sparked a race to make transportation ... and gasoline containing ethanol are starting to make an impact ... has also fueled a race to find new sources for ... many modern plastics, drugs, and fuels. Behind the scenes, American ...
Cached Biology Technology:Some great insights into the current Mergers & Acquisitions Market 2Some great insights into the current Mergers & Acquisitions Market 3Some great insights into the current Mergers & Acquisitions Market 4Some great insights into the current Mergers & Acquisitions Market 5Canadian firm buys Proventiv Therapeutics, makes ex-Bone Care exec CEO 2Canadian firm buys Proventiv Therapeutics, makes ex-Bone Care exec CEO 3UW prof turns sugar into diesel fuel, chemicals 2UW prof turns sugar into diesel fuel, chemicals 3
... Thermo Savant SpeedVac Concentrators set the standard ... SC110A SpeedVac uses a combination of centrifugal force, ... a single run., SC110A comes equipped with:, , ... chemical compatibility , ...
... Savant SpeedVac™ Concentrators set the standard for sample ... SpeedVac with large chamber uses a combination of ... samples in a single run. , SC210A comes ... for long lasting chemical compatibility ...
... (for aqueous, other low volatility and noxious ... to specific applications of molecular biology and ... heat-labile samples. The RC systems can be ... and a wide selection of rotors (eliminating ...
... Jouan RC Standard Bio for vacuum ... of molecular biology and biochemistry for rapid ... RC systems can be expanded with pumps, ... selection of rotors (eliminating sample loss by ...
Biology Products: