Navigation Links
Discovery may help prevent chemotherapy-induced anemia
Date:5/5/2013

stem cells. (The body's sympathetic nervous system helps in controlling most internal organsincreasing heart rate and dilating the pupils of the eye, for example.)

"Since many chemotherapies used in cancer treatment are neurotoxic, we wondered whether they might also damage sympathetic nerves in bone marrow itself, impairing the ability of hematopoietic cells to regenerate and to manufacture RBCs," said Dr. Frenette. "This possibility hadn't been examined before."

Dr. Frenette and his colleagues treated mice with seven cycles of cisplatin, a common chemotherapy drug with known neurotoxic effects. The cisplatin caused peripheral neuropathy problems similar to those seen in cancer patients. The mice were then given fresh bone marrow transplants to see how well their marrow would regenerate. Despite receiving fresh stem cells, the cisplatin-treated mice had delayed recovery of blood counts compared to controlssuggesting that the prior cisplatin treatments had affected the bone marrow and prevented hematopoietic stem cells from regenerating. By contrast, mice treated with carboplatina non-neurotoxic chemotherapyrecovered their ability to produce blood after bone marrow transplantation.

To confirm that healthy sympathetic nerves in the bone marrow are needed to regenerate hematopoietic stem cells and produce RBCs, the researchers selectively damaged sympathetic nerves in bone marrow using chemicals or genetic engineering. In both cases, the mice with the damaged sympathetic nerves were less able than control mice to recover after bone marrow transplant.

The researchers found that injury to these nerves could be reduced by giving mice nerve-protecting agents along with chemotherapy. Mice treated with seven cycles of cisplatin along with 4-methylcatechol (an experimental drug that reportedly protects sympathetic nerves) showed improved response to bone marrow transplantation, compared to controls.

Dr. Frenette and his collea
'/>"/>

Contact: Kim Newman
sciencenews@einstein.yu.edu
718-430-3101
Albert Einstein College of Medicine
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Discovery of a molecule that initiates maturation of mammalian eggs can lead to more IVF pregnancies
2. Annual Drug Discovery Conferences Being Held in Boston MA, Spring 2012
3. Discovery provides blueprint for new drugs that can inhibit hepatitis C virus
4. Unexpected discovery reveals a new mechanism for how the cerebellum extracts signal from noise
5. Discovery offers insight into treating viral stomach flu
6. Breast cancer risk gene discovery fast tracked by new technology
7. Tales from the crypt lead researchers to cancer discovery
8. New discovery may lead to effective prevention and treatment of graft-versus-host dsease
9. Stomata development in plants unraveled -- a valuable discovery for environmental research
10. Discovery reveals chromosomes organize into yarns
11. Bacteria discovery could lead to antibiotics alternatives
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/2/2014)... 2014) In the battle between our immune systems ... in bacteria-killing viruses known as phages. In a new ... In Health, Haiti,s National Public Health Laboratory, and elsewhere, ... up their virulence in order to survive. Importantly, the ... that cholera,s mutational escape from phage predation occurs during ...
(Date:9/2/2014)... integrity? Tell the truth; everyone has a tipping point. We ... lie if the benefit is great enough. Now, scientists have ... that decision. , The result was published online this ... prefer to be honest, even if lying is beneficial," said ... at the Virginia Tech Carilion Research Institute , where ...
(Date:9/2/2014)... September 2, 2014 Best-selling author Sam Kean stops ... the Megalodon, the 50-foot super shark that, despite what ... extinct. Learn all about it at http://youtu.be/KhFygIoW_MA . ... Tales of Madness, Love and the History of the ... getting the Reactions treatment in a 10-episode video series ...
Breaking Biology News(10 mins):War between bacteria and phages benefits humans 2War between bacteria and phages benefits humans 3Scientists find possible neurobiological basis for tradeoff between honesty, self-interest 2Scientists find possible neurobiological basis for tradeoff between honesty, self-interest 3Scientists find possible neurobiological basis for tradeoff between honesty, self-interest 4
... population lives in areas at risk of malaria transmission. ... and each year causes hundreds of thousands of deaths worldwide, ... The malaria-causing parasite, Plasmodium falciparum , is spread ... human blood. P. falciparum invades red blood ...
... impressive feat of nature, where plants harvest light energy ... at fantastically high efficiency. Indeed modern civilization became possible ... and clothing. While scientists have been able ... plants store solar energy as chemical energy, how developing ...
... 3, 2010 -- The latest discoveries and innovations in ... be presented this month at a major scientific conference ... aids, new technologies for monitoring fetal heartbeats, intriguing explorations ... the social lives of dolphins. The 2nd Pan-American/Iberian ...
Cached Biology News:UC Riverside cell biologist to investigate how malaria parasite multiplies in red blood cells 2The developmental dynamics of the maize leaf transcriptome 2Highlights from major acoustical science and technology conference, Nov. 15-19 2Highlights from major acoustical science and technology conference, Nov. 15-19 3Highlights from major acoustical science and technology conference, Nov. 15-19 4Highlights from major acoustical science and technology conference, Nov. 15-19 5Highlights from major acoustical science and technology conference, Nov. 15-19 6Highlights from major acoustical science and technology conference, Nov. 15-19 7Highlights from major acoustical science and technology conference, Nov. 15-19 8Highlights from major acoustical science and technology conference, Nov. 15-19 9Highlights from major acoustical science and technology conference, Nov. 15-19 10Highlights from major acoustical science and technology conference, Nov. 15-19 11Highlights from major acoustical science and technology conference, Nov. 15-19 12Highlights from major acoustical science and technology conference, Nov. 15-19 13
(Date:9/2/2014)... , Sept. 2, 2014 /PRNewswire/ - BIOREM Inc. (TSXV: BRM) ... $2.1 million. The orders consist of three large odour control ... . "These orders are consistent with the ... Peter Bruijns , President and CEO. "After a difficult ... we are now beginning to see sales growth. Our lower ...
(Date:9/1/2014)... NEW YORK , Sept. 1, 2014 /PRNewswire/ ... report is available in its catalogue: ... Opportunities, 2019 http://www.reportlinker.com/p02350445/India-Solid-Waste-Management-Vehicles-Market-Forecast-and-Opportunities-2019.html ... municipal corporations are the main governing bodies responsible ... management in cities. On an average, around 135,000 ...
(Date:8/31/2014)... 2014 2014 Market Research ... professional and in-depth research report on the ... information, including Polyacrylamide definition, classification, application, and ... overview. This research covers the international market ... global industry analysis covering macroeconomic environment & ...
(Date:8/29/2014)... The global companion diagnostics market ... It is expected to grow at a CAGR ... valued at $1.8 billion in 2013, according to ... , For more information regarding analysis details and ... research report, titled “Companion Diagnostics Market (Breast Cancer, ...
Breaking Biology Technology:India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 2India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 3India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 4India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 5India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 6India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 7India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 8International Polyacrylamide Industry & Copper Iodide Market Data Analysis Now Available at DeepResearchReports.com 2International Polyacrylamide Industry & Copper Iodide Market Data Analysis Now Available at DeepResearchReports.com 3Companion Diagnostics Market to Hit $5.6 Billion in 2019: Transparency Market Research 2Companion Diagnostics Market to Hit $5.6 Billion in 2019: Transparency Market Research 3
... for Critical Path Immunology created to discover and develop ... biomarkers for immune system-related diseases -, SAN FRANCISCO, March ... collaboration with Beckman Coulter, Inc. to,establish a Center for Critical ... in disease. This facility, which will be managed by,ITI and ...
... Patents Filed on Lead Compounds That Directly and Specifically Activate ... ... WOBURN, Massachusetts, March 31 Mercury Therapeutics,Inc. (MTI), a company ... it has filed for patent protection on,three lead compounds that directly ...
... ... development activities, MEDFORD, Mass. and ... unique microfluidic microarray system Geniom,today announced the formation of a ... of genetics and genomics,research. The SAB members, from top research ...
Cached Biology Technology:The Immune Tolerance Institute Announces Collaboration with Beckman Coulter Establishing a Multiplatform Immunophenotyping/Immunogenotyping Laboratory 2The Immune Tolerance Institute Announces Collaboration with Beckman Coulter Establishing a Multiplatform Immunophenotyping/Immunogenotyping Laboratory 3Mercury Therapeutics Patents Filed 2Mercury Therapeutics Patents Filed 3febit Forms Scientific Advisory Board 2febit Forms Scientific Advisory Board 3
Request Info...
Anti-ZFP200 Family: Zinc Finger Peptide Sequence: CGKSFNHKTNLNKHER...
Donor feline serum and plasma...
Collected from sexually mature, mixed sex, mixed breed cats. Physiochemical constituents are measured to ensure lot-to-lot consistency....
Biology Products: