Navigation Links
Discovery may help prevent chemotherapy-induced anemia
Date:5/5/2013

May 5, 2013 (Bronx, NY) Cancer chemotherapy can cause peripheral neuropathynerve damage often resulting in pain and muscle weakness in the arms and legs. Now, researchers at Albert Einstein College of Medicine of Yeshiva University have discovered that chemo also induces an insidious type of nerve damage inside bone marrow that can cause delays in recovery after bone marrow transplantation. The findings, made in mice and published online today in Nature Medicine, suggest that combining chemotherapy with nerve-protecting agents may prevent long-term bone marrow injury that causes anemia and may improve the success of bone marrow transplants.

Constantly regenerating and maturing, the hematopoietic (blood-producing) stem cells in our bone marrow produce billions of red blood cells (RBC) every day. Cancer chemotherapy is notorious for injuring the bone marrow, leading to anemia, or low RBC counts. But just how chemotherapy harms the bone marrow has not been clear.

Anemia can lead to numerous health problems including chronic fatigue, tachycardia (abnormally rapid heartbeat), cognitive impairment, shortness of breath, depression and dizziness. In addition, studies have shown that cancer patients who develop anemia have a 65 percent increased risk of death compared with cancer patients without anemia.

In an earlier study, senior author Paul Frenette, M.D., professor of medicine and of cell biology and director of the Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research at Einstein, found that sympathetic nerves within bone marrow direct the movement of hematopoietic
'/>"/>

Contact: Kim Newman
sciencenews@einstein.yu.edu
718-430-3101
Albert Einstein College of Medicine
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Discovery of a molecule that initiates maturation of mammalian eggs can lead to more IVF pregnancies
2. Annual Drug Discovery Conferences Being Held in Boston MA, Spring 2012
3. Discovery provides blueprint for new drugs that can inhibit hepatitis C virus
4. Unexpected discovery reveals a new mechanism for how the cerebellum extracts signal from noise
5. Discovery offers insight into treating viral stomach flu
6. Breast cancer risk gene discovery fast tracked by new technology
7. Tales from the crypt lead researchers to cancer discovery
8. New discovery may lead to effective prevention and treatment of graft-versus-host dsease
9. Stomata development in plants unraveled -- a valuable discovery for environmental research
10. Discovery reveals chromosomes organize into yarns
11. Bacteria discovery could lead to antibiotics alternatives
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/23/2014)... Huntington,s disease, most in their mid-thirties and forties, ... behavioral decline within two decades. "Mutant" protein clusters, ... disease, have been the primary focus of therapies ... new research from Prof. Gerardo Lederkremer and Dr. ... Cell Research and Immunology, in collaboration with Prof. ...
(Date:4/23/2014)... Valley, NY. (Apr. 23 2014) A ... neural stem cells (hNSCs) into the brains of ... after 22 and 24 months found that the ... and did not cause tumors. , The study ... Cell Transplantation but is currently freely ...
(Date:4/23/2014)... trope that the likelihood of an accurate group decision ... hold up when a collective faces a variety of ... Instead, Princeton University researchers report that smaller groups actually ... may become excessively focused on only certain pieces of ... what is known about collective intelligence, or the "wisdom ...
Breaking Biology News(10 mins):On the defensive 2On the defensive 3Study finds long-term survival of human neural stem cells transplanted into primate brain 2Too many chefs: Smaller groups exhibit more accurate decision-making 2Too many chefs: Smaller groups exhibit more accurate decision-making 3
... COLD SPRING HARBOR, N.Y. Combining ... with the versatility of lentiviral vectors gives researchers ... function both in vivo and in vitro. ... Protocols ( www.cshprotocols.org/TOCs/toc8_08.dtl ) features a pair ...
... parasite has waged a successful guerrilla war against the human ... Journal of Biological Chemistry has exposed one of ... which may aid in future drug development. , Malaria parasites ... their human hosts the parasites first set up shop in ...
... Cambridge, UK, 04 August 2008 - Disease Models & ... focus on translational research and the use of model organisms ... Biologists, DMM is a highly anticipated biomedical research ... and online today at http://DMM.biologists.org . DMM ...
Cached Biology News:Research exposes new target for malaria drugs 2Building bridges between the clinic and the laboratory 2
(Date:1/15/2014)... Scottsdale, Arizona (PRWEB) January 15, 2014 ... growth for Scottsdale’s Brain State Technologies®. They saw continued ... University Medical Center who were awarded a $1 million ... papers published in “Brain and Behavior” a peer reviewed ...
(Date:1/15/2014)... TAIPEI , Jan. 15, 2014 TaiGen Biotechnology ... an exclusive agreement with R-Pharm, a leading Russian pharmaceutical ... in the Russian Federation , ... Commonwealth Independent States (CIS). Nemonoxacin is a novel antibiotic for ...
(Date:1/14/2014)... January 14, 2014 Histogen, Inc., a ... of cells grown under simulated embryonic conditions, today announced ... with Suneva Medical, Inc. for physician-dispensed aesthetic products containing ... , This agreement is an amendment to the existing ...
(Date:1/14/2014)... NY (PRWEB) January 14, 2014 EquitiesIQ, ... Alliqua, Inc. (OTCQB: ALQA). Alliqua is an emerging biomedical ... serve the wound care market. , Free report download: ... restructured with a seasoned management team and Board, which ...
Breaking Biology Technology:Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 2TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 4Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 2Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 3EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3
... , SAN DIEGO, Sept. 8 eBioscience Corporation, ... today the acquisition of NatuTec GmbH, a leading distributor of high-quality ... , , "For the past 10 years, NatuTec ... Todd R. Nelson, CEO of eBioscience. "The NatuTec acquisition provides ...
... , LAIYANG, China, Sept. 8 ... "Company", "Jiangbo"), a,U.S. pharmaceutical company with its principal operations ... announced guidance for,fiscal year 2009. The Company expects ... million in revenue and operating income of $40 to ...
... , , RICHMOND, Calif., ... Institute used zinc finger nucleases (ZFNs) designed by Sangamo BioSciences, ... modify the genomes of human embryonic stem cells (hESCs) and ... useful tools in drug discovery and development. Scientists also ...
Cached Biology Technology:eBioscience Corporation Acquires NatuTec GmbH 2Jiangbo Pharmaceuticals Reaffirms Guidance for Fiscal 2009 2Sangamo's Zinc Finger Nuclease Technology Used to Efficiently Modify Human Stem Cells 2Sangamo's Zinc Finger Nuclease Technology Used to Efficiently Modify Human Stem Cells 3Sangamo's Zinc Finger Nuclease Technology Used to Efficiently Modify Human Stem Cells 4
... The INK4a-ARF locus encodes two unrelated proteins ... p14^ARF^ arrests the cell cycle in a ... promotes the rapid degradation of mdm2 proteinrequired ... and accumulation. This interaction is mediated ...
... CLS number is a new ... match Cornings product number. If ... order under the old Sigma-Aldrich ... service for assistance. Mfr ...
... Insulin exerts its ... the insulin receptor, a ... of two Alpha subunits ... arranged in the following ...
... is a new product number, ... product number. If showing no ... the old Sigma-Aldrich number (Z37,208-0) ... assistance. Mfr Desig: Corning ...
Biology Products: