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Discovery may help prevent HIV 'reservoirs' from forming
Date:4/17/2013

rocess in which phosphate groups attach to other molecules, thereby activating various signaling and regulatory mechanisms within the cell.) When SAMHD1 is phosphorylated the situation in immune cells that divide the cell is not protected from being infected with HIV-1. When the protein is not phosphorylated as occurs in the nondividing macrophages the cell is protected from HIV infection.

"We are currently exploring ways to keep this protein unphosphorylated so that HIV reservoirs will never be formed," said Dr. Diaz-Griffero.


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Contact: Deirdre Branley
sciencenews@einstein.yu.edu
718-430-3101
Albert Einstein College of Medicine
Source:Eurekalert

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