Navigation Links
Discovery may help defang viruses
Date:8/28/2007

Researchers may be able to tinker with a single amino acid of an enzyme that helps viruses multiply to render them harmless, according to molecular biologists who say the discovery could pave the way for a fast and cheap method of making vaccines.

"We have successfully tested this technique with poliovirus," said Craig Cameron, the Paul Berg professor of biochemistry and molecular biology at Penn State. "And we think it is applicable to most other viruses." Viruses have a simple mission; infect a cell, make more viruses, and then break out of the cell to infect more cells. This calls for fast and efficient multiplication. Viruses do this with the help of an enzyme called polymerase, whose main job is to assist in making more copies of the virus.

Once a virus infects a cell, there is a race against the clock between the virus, which is trying to multiply quickly, and the immune system trying to control the spread. A virus can cause disease and death if it can spread more rapidly than the immune system can neutralize it.

But if the body has been exposed to a vaccine weakened form of the virus in this case the body can respond more rapidly when it is exposed to the virulent strain. The key to developing vaccines is finding the one strain mutation that will prime the immune system without causing disease.

The Penn State researchers may have done just that. Cameron and his colleagues, Jamie Arnold and Christian Castro, both research associates, have identified a key amino acid in the polymerase of poliovirus that controls the speed and accuracy with which the virus is able to multiply.

By replacing this key residue with different amino acids, the researchers were able to generate mutants of the virus that are essentially harmless.

"We found that very subtle changes in the chemistry at this location of the polymerase has dramatic effects on weakening the virus," said Cameron, who has a provisional patent on the technique.

W
'/>"/>

Contact: Amitabh Avasthi
axa47@psu.edu
814-865-9481
Penn State
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Protein discovery could unlock the secret to better TB treatment
2. Purdue proves concept of using nano-materials for drug discovery
3. Fundamental Finding Yields Insight into Stem Cells, Cancer; Opens Door to Drug Discovery
4. Discovery of key proteins shape could lead to improved bacterial pneumonia vaccine
5. UCSD Discovery Shows How Embryonic Stem Cells Perform Quality Control Inspections
6. Discovery Could Lead To Novel Approaches In HIV Treatment
7. UCSD discovery may help extend life of natural pesticide
8. Discovery Promises Simpler Therapy for Sickle Cell Disease
9. Discovery may lead to better Candidiasis drug
10. Leprosy microbes lead scientists to immune discovery
11. Biochemists report discovery of structure of major piece of telomerase; implications for cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/29/2014)... suggesting air pollutants released by unconventional oil and gas ... is published today in the open access journal ... and formaldehyde were found. The study is the first ... live near production sites and could be used to ... gas come from reserves that do not readily flow ...
(Date:10/29/2014)... (October 29, 2014, Beaverton, OR) New research ... 11th International Conference in Houston, TX showed for ... eliminate HPV infection in women using a readily ... The study, presented by Dr. Judith A. Smith, ... Gynecology and Reproductive Sciences at The University of ...
(Date:10/29/2014)... their food, but they also need protection from its harmful ... of molecules in plants that shields them from sun damage. ... American Chemical Society , one team reports on the mechanics ... and colleagues at Purdue University note that the harsh ultraviolet ... to plant DNA and, as a result, hinder plant growth. ...
Breaking Biology News(10 mins):Air quality and unconventional oil and gas sites 2Air quality and unconventional oil and gas sites 3HPV infections in women eradicated by AHCC, Japanese mushroom extract 2
... -- New research is shedding light on the preferred habitat ... often overlooked species in Arctic marine food webs. Squid, ... important role as prey in Arctic waters for species such ... Kathleen Gardiner, a PhD candidate in the Biological Sciences Department ...
... -- Montana State University historian Timothy J. LeCain recently ... best new book in environmental history. The ... that Wired America and Scarred the Planet," tells the ... Berkeley Pit in Butte, Mont., and the Bingham ...
... 7, 2010) More than 1600 genetics researchers who use ... to study basic aspects of biology ranging from memory to ... underlie evolution, will be gathering in Washington, DC, for the ... Genetics Society of America, and beginning this evening at the ...
Cached Biology News:Habitat of elusive Northern squid documented by researcher 2Montana State University historian wins prize for book on Montana, Utah copper mines 2Drosophilists fly into DC for 51st Annual Drosophila Research Conference 2
(Date:10/30/2014)... Calif. , Oct. 30, 2014  Ardelyx, ... biopharmaceutical company focused on cardio-renal, gastrointestinal and metabolic ... quarter 2014 financial results on Thursday, November 6, ... will host a live conference call and webcast ... results and provide a business update. ...
(Date:10/30/2014)... 30, 2014 On October 26th ... Showcase in Chicago, leading applied stem cell research ... Wade McKenna presented talks on New Techniques for ... Applications For Stem Cells. , Dr. Riordan focused ... the properties of AlphaGEMS that include: wound healing; ...
(Date:10/30/2014)... James Sherley says he has been working ... cell technology since his days as a principal investigator at ... late 1990’s. Sherley founded the ASCTC as a new ... the intellectual property developed in Sherley’s research over the years ... of Technology (MIT), and more recently as a senior scientist ...
(Date:10/30/2014)... 2014 Avure Technologies celebrates a year of ... member of its fleet of high volume High Pressure Processing ... as we return to PackExpo this year, which is where ... Vegas,” said Jeff Williams, CEO at Avure. “Sales of the ... to be meeting the challenges of market demand for higher ...
Breaking Biology Technology:Ardelyx to Report Third Quarter 2014 Financial Results on November 6, 2014 2Riordan-McKenna Institute Founders, Neil Riordan, PhD and Orthopedic Surgeon, Dr. Wade McKenna Present at the Mid American Regenerative and Cellular Medicine Showcase 2Riordan-McKenna Institute Founders, Neil Riordan, PhD and Orthopedic Surgeon, Dr. Wade McKenna Present at the Mid American Regenerative and Cellular Medicine Showcase 3Riordan-McKenna Institute Founders, Neil Riordan, PhD and Orthopedic Surgeon, Dr. Wade McKenna Present at the Mid American Regenerative and Cellular Medicine Showcase 4Boston’s Adult Stem Cell Technology Center, LLC Introduces A New Technology for Monitoring Previously Elusive Adult Stem Cells 2Boston’s Adult Stem Cell Technology Center, LLC Introduces A New Technology for Monitoring Previously Elusive Adult Stem Cells 3Boston’s Adult Stem Cell Technology Center, LLC Introduces A New Technology for Monitoring Previously Elusive Adult Stem Cells 4In High Demand: New High Pressure Processing (HPP) System with Maximum Throughput Drives Strong Sales 2In High Demand: New High Pressure Processing (HPP) System with Maximum Throughput Drives Strong Sales 3
... EMERYVILLE, Calif., Sept. 17 Neurobiological Technologies, Inc. (Nasdaq: ... 15, 2009, it received a letter from The Nasdaq Stock ... has closed below $1.00 per share for 30 consecutive business ... $1.00 per share is a deficiency under Nasdaq,s requirements for ...
... , , EAST HANOVER, N.J., ... approved Valturna(R) (aliskiren and valsartan) tablets, the first and only medicine ... as the renin angiotensin aldosterone system (RAAS), an important regulator of ... indicated for the treatment of high blood pressure in patients not ...
... , ABBOTT PARK, Ill., Sept. 17 The board of directors ... of 40 cents per share. , , This marks ... The cash dividend is payable Nov. 15, 2009, to shareholders of record at ... Abbott has increased its dividend payout for 37 consecutive years - including an ...
Cached Biology Technology:Neurobiological Technologies Receives Nasdaq Closing Bid Price Notification 2Photo: Novartis Receives FDA Approval for Valturna(R), a Single-Pill Combination of valsartan and aliskiren, to Treat High Blood Pressure 2Photo: Novartis Receives FDA Approval for Valturna(R), a Single-Pill Combination of valsartan and aliskiren, to Treat High Blood Pressure 3Photo: Novartis Receives FDA Approval for Valturna(R), a Single-Pill Combination of valsartan and aliskiren, to Treat High Blood Pressure 4Photo: Novartis Receives FDA Approval for Valturna(R), a Single-Pill Combination of valsartan and aliskiren, to Treat High Blood Pressure 5Photo: Novartis Receives FDA Approval for Valturna(R), a Single-Pill Combination of valsartan and aliskiren, to Treat High Blood Pressure 6Photo: Novartis Receives FDA Approval for Valturna(R), a Single-Pill Combination of valsartan and aliskiren, to Treat High Blood Pressure 7