Navigation Links
Discovery demonstrates potential MS therapy could kill brain cells
Date:5/6/2011

Edmonton Researchers with the Faculty of Medicine & Dentistry at the University of Alberta have discovered that some "protective" T-cells can kill neurons. This finding is significant because a specific type of T-cell therapy is being touted in the medical community as a potential treatment for MS and other autoimmune conditions.

Dr. Fabrizio Giuliani and his post-doctoral fellow, Yohannes Haile, both from the Division of Neurology, collaborated on this research which was recently published in the Journal of Leukocyte Biology, a peer-reviewed medical journal.

"Using T-cells has been seen as a potential treatment for autoimmune diseases," says Dr. Giuliani. "But these cells that are supposed to be regulatory, when activated, they can kill. In our hands, at least, they were able to kill neurons. So this is very important. In MS literature, they were starting to talk about using the infusion of these cells as treatment. This area needs to be studied more before these cells are used as a therapy for MS patients."

The finding was serendipitous, says Giuliani.

"We were using some of the cells that we have described here as a control in our project. And then the T-cells did something interesting, something we weren't expecting. In fact, we were expecting the exact opposite response with these cells.

"We were looking at how a specific type of T-cell could prevent neuronal death and then we found out they were doing the killingThese are the best findings when you are expecting something different and then you observe an amazing phenomenon."

T-cells are very important their primary role is to attack foreign viruses or bacteria and to regulate or maintain immune system tolerance. However, when T-cell tolerance is disrupted, they can cause autoimmune diseases.

Researchers in the medical community have thought if they could carefully collect regulatory T-cells and inject them into patients with autoimmune diseases, these T-cells could keep autoimmune diseases under control. Work with lab models that had MS and were treated with T-cells was promising. However, recent studies of human cells have shown humans have different subpopulations of T-cells some of which do not have a regulatory function.

Giuliani and Haile worked with different subpopulations of T-cells and discovered some were toxic to neurons. Giuliani and his colleague are the first medical researchers to demonstrate that activating a specific type of T-cell can kill brain cells.

They want to continue their work in this area to determine what causes some T-cells to behave this way.

"We want to take the research further. We want to continue this story in an attempt to try and solve the mystery."


'/>"/>

Contact: Raquel Maurier
raquel.maurier@ualberta.ca
780-492-5986
University of Alberta Faculty of Medicine & Dentistry
Source:Eurekalert

Related biology news :

1. Worm discovery could help 1 billion people worldwide
2. New discovery could green up hundreds of everyday products
3. Discovery identifies elaborate G-protein network in plants
4. A chance discovery may revolutionize hydrogen production
5. A world first: The discovery of a common genetic cause of autism and epilepsy
6. Discovery of protein that alters nutrition of breast cancer cells
7. Missouri Botanical Garden makes rare discovery of plant genus
8. Discovery of a biochemical basis for broccolis cancer-fighting ability
9. Discovery of source of glycogen manufacturing errors sheds light on fatal disease
10. MU researchers believe discovery could lead to testing that displaces colonoscopies
11. Discovery of blood proteins that are red flags for ectopic pregnancy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/10/2017)... Feb 10, 2017 Research and ... "Personalized Medicine - Scientific and Commercial Aspects" to ... ... Diagnosis is integrated with therapy for selection of treatment as ... detection and prevention of disease in modern medicine. Biochip/microarray technologies ...
(Date:2/8/2017)... YORK , Feb. 8, 2017 About ... individual,s voice to match it against a stored ... such as pitch, cadence, and tone are compared ... require minimal hardware installation, as most PCs already ... for different transactions. Voice recognition biometrics are most ...
(Date:2/8/2017)... Report Highlights ... The global synthetic-biology market reached nearly $3.9 billion in ... a compound annual growth rate (CAGR) of 24.0% through 2021. ... for synthetic biology. - Analyses of global market trends, with ... annual growth rates (CAGRs) through 2021. - Coverage of core ...
Breaking Biology News(10 mins):
(Date:3/23/2017)... ... March 23, 2017 , ... AxioMed president, Jake Lubinski, describes ... characteristics when deformed, which is identical to how the human discs work to ... and return to its natural state along a hysteresis curve, exactly like a ...
(Date:3/23/2017)... -- GlobeImmune, Inc. today announced it has entered into a ... of its common stock to NantCell, Inc., a member ... sale of its common stock, NantCell has agreed to ... 200,000 shares, an estimated $2.0 million in value, of ... to enter into this strategic agreement with NantCell," said ...
(Date:3/23/2017)... York , March 23, 2017 According ... plasma products and derivatives market is fragmented due to the presence of ... such as Proliant, Thermo Fisher , and Sigma-Aldrich, compete with ... these three companies, collectively, held more than 76% of this market ... As ...
(Date:3/22/2017)... ... March 22, 2017 , ... Researchers face a ... lab samples to full-size tissues, bones, even whole organs to implant in people ... delivers blood deep into the developing tissue. , Current bioengineering techniques, including ...
Breaking Biology Technology: