Navigation Links
Discovery demonstrates potential MS therapy could kill brain cells
Date:5/6/2011

Edmonton Researchers with the Faculty of Medicine & Dentistry at the University of Alberta have discovered that some "protective" T-cells can kill neurons. This finding is significant because a specific type of T-cell therapy is being touted in the medical community as a potential treatment for MS and other autoimmune conditions.

Dr. Fabrizio Giuliani and his post-doctoral fellow, Yohannes Haile, both from the Division of Neurology, collaborated on this research which was recently published in the Journal of Leukocyte Biology, a peer-reviewed medical journal.

"Using T-cells has been seen as a potential treatment for autoimmune diseases," says Dr. Giuliani. "But these cells that are supposed to be regulatory, when activated, they can kill. In our hands, at least, they were able to kill neurons. So this is very important. In MS literature, they were starting to talk about using the infusion of these cells as treatment. This area needs to be studied more before these cells are used as a therapy for MS patients."

The finding was serendipitous, says Giuliani.

"We were using some of the cells that we have described here as a control in our project. And then the T-cells did something interesting, something we weren't expecting. In fact, we were expecting the exact opposite response with these cells.

"We were looking at how a specific type of T-cell could prevent neuronal death and then we found out they were doing the killingThese are the best findings when you are expecting something different and then you observe an amazing phenomenon."

T-cells are very important their primary role is to attack foreign viruses or bacteria and to regulate or maintain immune system tolerance. However, when T-cell tolerance is disrupted, they can cause autoimmune diseases.

Researchers in the medical community have thought if they could carefully collect regulatory T-cells and inject them into patients with autoi
'/>"/>

Contact: Raquel Maurier
raquel.maurier@ualberta.ca
780-492-5986
University of Alberta Faculty of Medicine & Dentistry
Source:Eurekalert

Page: 1 2

Related biology news :

1. Worm discovery could help 1 billion people worldwide
2. New discovery could green up hundreds of everyday products
3. Discovery identifies elaborate G-protein network in plants
4. A chance discovery may revolutionize hydrogen production
5. A world first: The discovery of a common genetic cause of autism and epilepsy
6. Discovery of protein that alters nutrition of breast cancer cells
7. Missouri Botanical Garden makes rare discovery of plant genus
8. Discovery of a biochemical basis for broccolis cancer-fighting ability
9. Discovery of source of glycogen manufacturing errors sheds light on fatal disease
10. MU researchers believe discovery could lead to testing that displaces colonoscopies
11. Discovery of blood proteins that are red flags for ectopic pregnancy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... No matter how many times it,s demonstrated, ... communicating creatures. , But by using a ... radically alter their behavior to suit their population. ... them are present, and act accordingly. , Once ... it may change from innocuous to pathogenic, or ...
(Date:9/18/2014)... Our genetic information is stored in DNA, tiny strands ... of our bodies. To express this genetic data, our ... the instructions into proteins that perform tasks in our ... new type of RNA molecule. Unlike all other known ... RNA. Although circRNA molecules are abundant, little has been ...
(Date:9/18/2014)... Americans across racial and ethnic groups describe losing ... their day-to-day life, more so than other conditions ... (57% of African-Americans, 49% of non-Hispanic whites, 43% ... which disease or ailment is the worst that ... African-Americans followed by AIDS/HIV. Hispanics and Asians ...
Breaking Biology News(10 mins):Researchers study vital 'on/off switches' that control when bacteria turn deadly 2Researchers study vital 'on/off switches' that control when bacteria turn deadly 3Scientists find how mysterious 'circular RNA' is formed, claim muscular dystrophy link 2Americans rate losing eyesight as having greatest impact on their lives 2Americans rate losing eyesight as having greatest impact on their lives 3
... breast cancer families with known genetic mutations do not all ... to a new international study involving the University of Melbourne. ... or BRCA2 are at least 10 times more likely to ... new study found that women who do not have a ...
... DARIEN, IL Poor sleep quality in both early ... of delivering preterm. A study published in the Nov. ... significant risk for preterm birth in women reporting sleep disruptions ... after medical risk factors and income levels were taken into ...
... MADISON During the past decade, voluntary contracts called ... land. Embodied in an agreement between landowners ... differing goals, structures and financial arrangements. As ... million acres, questions have multiplied. Are easements the most ...
Cached Biology News:Not all women in breast cancer families share high risk 2Poor sleep quality in first, third trimesters linked to preterm births 2For land conservation, formal and informal relationships influence success 2For land conservation, formal and informal relationships influence success 3
(Date:9/19/2014)...  An entire month is dedicated to one of ... disease (CMT) – a debilitating neuromuscular disease affecting the ... weakness, and foot and hand deformities. CMT affects 1 ... is a progressive disease, and over time patients lose ... such as leg braces, wheelchairs and scooters to get ...
(Date:9/19/2014)... Charlotte, NC (PRWEB) September 19, 2014 ... Certified Biobased Product Label for its Organic Cotton ... the product’s amount of renewable biobased ingredients meets or ... or intermediate materials composed in whole or in significant ... “This logo/label will allow our Organic cotton to be ...
(Date:9/18/2014)... USA (PRWEB) September 18, 2014 Bipartisan ... of a bill designed to stimulate development and commercialization ... is being praised by leaders of SPIE, the ... the Revitalizing American Manufacturing and Innovation (RAMI) Act, now ... bill’s authors have said they are optimistic that it ...
(Date:9/18/2014)... Sept. 18, 2014  Health Enhancement Products, Inc. (OTCQB: HEPI), ... algae bioactive compounds and metabolic processes, is pleased to announce ... of directors. Ms. Nola E. Masterson , a ... the board effective September 17, 2014. "We,re ... join our board," states Andrew Dahl , President and ...
Breaking Biology Technology:September is Charcot-Marie-Tooth (CMT) Awareness Month - Scheduled events, activities and important partnerships announced throughout the month! 2Barnhardt Manufacturing Company Earns USDA Certified Biobased Product Certification and Label for Organic Cotton 2House passage of high-tech manufacturing bill is move toward stronger economy, say SPIE leaders 2House passage of high-tech manufacturing bill is move toward stronger economy, say SPIE leaders 3Health Enhancement Announces New Board Member In Advance Of Annual Shareholder Meeting 2
... ... Medicine is set to revolutionize the healthcare industry. As our knowledge of genetics and ... , ... (PRWEB) May 18, 2010 -- The era of Personalized Medicine is set to revolutionize ...
... 18, 2010 Among more than 5000 poster,abstracts, Aprea AB has ... Oncology (ASCO) Meeting in Chicago . The,presentation will describe the scientific ... candidate APR-246. , , , ... Aprea,s drug candidate APR-246 belongs to a new class of ...
... NINGBO, China , May ... Ltd. (TAIJI),s FGD (Flue-gas desulfurization),technology was officially put into ... project, TAIJI chose to use steel slag as an ... desulfurization. In,comparison to the use of lime agents, the ...
Cached Biology Technology:Arrowhead Releases New Report Assessing State of Personalized Medicine Market 2Arrowhead Releases New Report Assessing State of Personalized Medicine Market 3Aprea to Present Phase I/II Trial Design 2Aprea to Present Phase I/II Trial Design 3TAIJI Announces Official Operation of Its Sintering FGD Project for Tangshan 2
... The four-bay DNA Engine Tetrad ... of interchangeable Alpha units (sample-holder, heat-pump ... numbers of vessels. A Pentium-class computer ... displays current block, sample, and lid ...
Printer paper for Model 680 series readers is used with the thermal printers of the Model 680 and Model 680 XR microplate readers. Supplied as 2 rolls....
... for 2-D separations. The cell has a six-gel ... xi multi-cell can be customized for several parameters: ... cooling system. The PROTEAN II xi multi-cell can ... multi-cell for a wider format that accommodates 17 ...
... is tailored to highly enrich ... rat spleen cells. Cells are ... compatible 0.5 Tesla) immunomagnetic negative ... content of the enriched fraction ...
Biology Products: