Navigation Links
Discovery could yield treatment for cocaine addicts
Date:3/15/2013

EAST LANSING, Mich. --- Scientists have discovered a molecular process in the brain triggered by cocaine use that could provide a target for treatments to prevent or reverse addiction to the drug.

Reporting in the Journal of Neuroscience, Michigan State University neuroscientist A.J. Robison and colleagues say cocaine alters the nucleus accumbens, the brain's pleasure center that responds to stimuli such as food, sex and drugs.

"Understanding what happens molecularly to this brain region during long-term exposure to drugs might give us insight into how addiction occurs," said Robison, assistant professor in the Department of Physiology and the Neuroscience Program.

The researchers found that cocaine causes cells in the nucleus accumbens to boost production of two proteins, one associated with addiction and the other related to learning. The proteins have a reciprocal relationship -- they increase each other's production and stability in the cells -- so the result is a snowball effect that Robison calls a feed-forward loop.

Robison and colleagues demonstrated that loop's essential role in cocaine responses by manipulating the process in rodents. They found that raising production of the protein linked to addiction made animals behave as if they were exposed to cocaine even when they weren't. They also were able to break the loop, disrupting rodents' response to cocaine by preventing the function of the learning protein.

"At every level that we study, interrupting this loop disrupts the process that seems to occur with long-term exposure to drugs," said Robison, who conducted the study as a postdoctoral fellow at Mount Sinai School of Medicine in New York City before joining the faculty at MSU.

Robison said the study was particularly compelling because it found signs of the same feed-forward loop in the brains of people who died while addicted to cocaine.

"The increased production of these proteins
'/>"/>

Contact: Andy McGlashen
andy.mcglashen@cabs.msu.edu
517-355-5158
Michigan State University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Discovery may explain how prion diseases spread between different types of animals
2. Gene discovery reveals importance of eating your greens
3. IU discovery on animal memory opens doors to research on memory impairment diseases
4. Cell discovery could hold key to causes of inherited diseases
5. New scorpion discovery near metropolitan Tucson, Arizona
6. The discovery of a new genus of crustacean and 5 new species
7. A*STAR scientists groundbreaking discovery of nucleus structure crucial to understanding diseases
8. Discovery of sexual mating in Candida albicans could provide insights into infections
9. New discovery in autism-related disorder reveals key mechanism in brain development and disease
10. Discovery of Africa moth species important for agriculture, controlling invasive plants
11. Discovery may pave way to genetically enhanced biofuel crops
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/16/2015)... , June 16, 2015 Fingerprint Cards ... communicated that it will amount to at least 340 MSEK ... to the rapid increase in market growth and orders received ... communicated guidance that revenue for 2015 will exceed 1,500 MSEK ... to approximately 2,200 MSEK. Due to receipt of ...
(Date:6/15/2015)... YORK , June 15, 2015 ... today from Telstra reveals the majority of US consumers using ... them via biometrics, such as fingerprint and voiceprint, instead of ... According to Telstra,s " Mobile Identity   - ... " report, with smartphones now the primary channel used ...
(Date:6/12/2015)... 2015  Securus Technologies, a leading provider of ... safety, investigation, corrections and monitoring, announced the United ... capture, analyze and identify participants of a video ... This system can: , Identify ... subsequent sign-on process is actually the person participating ...
Breaking Biology News(10 mins):Fingerprint Cards Raises the Revenue Guidance for Q2 2015 and for the Full Year 2015 2Fingerprint Cards Raises the Revenue Guidance for Q2 2015 and for the Full Year 2015 3One in Four US Consumers Would Share Their DNA With Their Bank to Secure Financial and Personal Information, Telstra Report Finds 2One in Four US Consumers Would Share Their DNA With Their Bank to Secure Financial and Personal Information, Telstra Report Finds 3One in Four US Consumers Would Share Their DNA With Their Bank to Secure Financial and Personal Information, Telstra Report Finds 4Securus Announces Patent Issued for Authorized Presence Verification During Video Visitation 2
... to solve the puzzle of when people develop celiac ... School of Medicine Center for Celiac Research to some ... is on the rise with evidence of increasing cases ... in the Annals of Medicine supports both ...
... associated with race may be more closely linked to social ... according to a new Henry Ford Hospital study. Researchers ... are at greater risk for late stage cancer, there was ... survival. In fact, the study shows only 5 ...
... WASHINGTON, D.C. Following is a statement by ... Force on American Innovation urges the U.S. Senate to ... Promote Excellence in Technology, Education, and Science) Act to ... in place and that the U.S. remains competitive in ...
Cached Biology News:UM School of Medicine Center for Celiac Research finds rate of celiac disease is growing 2UM School of Medicine Center for Celiac Research finds rate of celiac disease is growing 3Genetic ancestry: A new look at racial disparities in head and neck cancer 2
(Date:7/1/2015)... ... July 01, 2015 , ... Apex Therapeutics announced today that ... in Philadelphia, PA. , The presentation took place on Tuesday, June 16 ... for the development of APX3330 for the treatment of pancreatic cancer. A copy ...
(Date:6/30/2015)... -- R-Japan Co.,Ltd. obtained the license of cell processing facility ... the Ministry of Health, Labour and Welfare Kinki Bureau of ... The fact that R- Japan received the ... and Medical Devices Agency (PMDA) on May 18, 2015 two ... cell manufacturing service to medical institutions. As of November 25, ...
(Date:6/30/2015)... ... June 30, 2015 , ... Park Systems ... advanced scientific research into new classes of Nanoscale Graphene-based materials poised to revolutionize ... 'the wonder material of the 21st Century' by the researchers who were awarded ...
(Date:6/30/2015)...  Today, Americord Registry, one of the fastest growing cord ... a partner at Kirkland & Ellis LLP, as the newest ... http://photos.prnewswire.com/prnh/20150630/226958LOGO   "We are thrilled about ... Martin Smithmyer , CEO of Americord. "He brings a wealth ... assist Americord,s growth and vision." Andrew Horne ...
Breaking Biology Technology:Apex Therapeutics Presented Company Overview at This Year’s BIO International Convention in Philadelphia, PA 2R-Japan Obtained Autologous Stem Cell Manufacturing License from the Ministry of Health, Labour and Welfare 2How Graphene–based Nanomaterials and Films Revolutionize Science Explained in July 9 Webinar Hosted by Park Systems 2How Graphene–based Nanomaterials and Films Revolutionize Science Explained in July 9 Webinar Hosted by Park Systems 3How Graphene–based Nanomaterials and Films Revolutionize Science Explained in July 9 Webinar Hosted by Park Systems 4Americord Registry Announces Andrew Horne as Advisory Board Member 2
... ExonHit Therapeutics S.A.,(Alternext: ALEHT), a drug and ... its new SpliceArray(TM) for use in studying ... help our clients accelerate,and refine their therapeutic ... resolution expression profiling analysis, we identify novel,transcripts ...
... modern world, largely due to properties that render the ... One of their most useful qualities, however - the ... stress - is also one of the most puzzling., ... to change shape to absorb energy rather than breaking ...
... exterior of your house always looking good, without cleaning ... is now possible with paint that can maintain itself ... , A process for producing photo-catalytic, self-cleaning coatings ... for Science, Technology and Research), and licensed to Haruna ...
Cached Biology Technology:ExonHit Launches Mouse Genome SpliceArray(TM) for use in Human Disease Modeling Studies 2ExonHit Launches Mouse Genome SpliceArray(TM) for use in Human Disease Modeling Studies 3Fast molecular rearrangements hold key to plastic’s toughness 2Fast molecular rearrangements hold key to plastic’s toughness 3Photo-catalytic, self cleaning coating for building exteriors 2Photo-catalytic, self cleaning coating for building exteriors 3Photo-catalytic, self cleaning coating for building exteriors 4
...
Kit for testing the ability of a compound to simulate lipolysis in cultured human adipocytes. Kit contains controls, buffers and reagents for detecting glycerol and non-esterified free fatty acids. A...
The strip cap tool is a used for properly seating 8- and 12-cap strips in microplates or strip tubes. A grooved channel on one side is designed to seat domed caps, while the flat edge on the opposite...
... Time- and temperature-controlled microwave oven ... and Antigen Retrieval of formalin-fixed, ... ease of use, high throughput ... high performance. When used in ...
Biology Products: