Navigation Links
Discovery could yield treatment for cocaine addicts
Date:3/15/2013

EAST LANSING, Mich. --- Scientists have discovered a molecular process in the brain triggered by cocaine use that could provide a target for treatments to prevent or reverse addiction to the drug.

Reporting in the Journal of Neuroscience, Michigan State University neuroscientist A.J. Robison and colleagues say cocaine alters the nucleus accumbens, the brain's pleasure center that responds to stimuli such as food, sex and drugs.

"Understanding what happens molecularly to this brain region during long-term exposure to drugs might give us insight into how addiction occurs," said Robison, assistant professor in the Department of Physiology and the Neuroscience Program.

The researchers found that cocaine causes cells in the nucleus accumbens to boost production of two proteins, one associated with addiction and the other related to learning. The proteins have a reciprocal relationship -- they increase each other's production and stability in the cells -- so the result is a snowball effect that Robison calls a feed-forward loop.

Robison and colleagues demonstrated that loop's essential role in cocaine responses by manipulating the process in rodents. They found that raising production of the protein linked to addiction made animals behave as if they were exposed to cocaine even when they weren't. They also were able to break the loop, disrupting rodents' response to cocaine by preventing the function of the learning protein.

"At every level that we study, interrupting this loop disrupts the process that seems to occur with long-term exposure to drugs," said Robison, who conducted the study as a postdoctoral fellow at Mount Sinai School of Medicine in New York City before joining the faculty at MSU.

Robison said the study was particularly compelling because it found signs of the same feed-forward loop in the brains of people who died while addicted to cocaine.

"The increased production of these proteins
'/>"/>

Contact: Andy McGlashen
andy.mcglashen@cabs.msu.edu
517-355-5158
Michigan State University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Discovery may explain how prion diseases spread between different types of animals
2. Gene discovery reveals importance of eating your greens
3. IU discovery on animal memory opens doors to research on memory impairment diseases
4. Cell discovery could hold key to causes of inherited diseases
5. New scorpion discovery near metropolitan Tucson, Arizona
6. The discovery of a new genus of crustacean and 5 new species
7. A*STAR scientists groundbreaking discovery of nucleus structure crucial to understanding diseases
8. Discovery of sexual mating in Candida albicans could provide insights into infections
9. New discovery in autism-related disorder reveals key mechanism in brain development and disease
10. Discovery of Africa moth species important for agriculture, controlling invasive plants
11. Discovery may pave way to genetically enhanced biofuel crops
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... nuts, cashews, hazelnuts, macadamias, pecans, pine nuts, pistachios and ... British Medical Journal Open (BMJ Open) (i) and ... article looked at the effects of tree nuts ... nut consumption resulted in a significant decrease in triglycerides ... article focused on the effect of tree nuts on ...
(Date:7/30/2014)... Society (ACS) announced today that David L. Kaplan, Ph.D., ... Science & Engineering as editor-in-chief. With the first ... journal will feature high-quality research in the rapidly burgeoning ... derived materials that interact with living or biological systems. ... the tremendous growth in the field of biomaterials over ...
(Date:7/30/2014)... The San Antonio Life Sciences Institute (SALSI), a joint ... (UTSA) and The University of Texas Health Science Center ... Postdoc Initiative Pilot Program. The winners, Emily Boice from ... will receive $25,000 for their project titled, "Novel engineered ... post-ischemic environment." , Boice and Huang,s research is focused ...
Breaking Biology News(10 mins):New international tree nut council study looks at nuts, diabetes and metabolic syndrome 2ACS Biomaterials Science & Engineering: Brand-new journal launches in 2015, names editor 2
... the predator-prey relationship can affect the flow of carbon ... environment may offer a new way of looking at ... The study, conducted by researchers at the Yale ... week in the Proceedings of the National Academy ...
... due to rising carbon dioxide levels will reduce the density ... and erosion, according to a new study of corals growing ... The study, led by researchers at the University of ... the National Academy of Sciences ( PNAS ), is ...
... A University of Maryland-led team of policy experts ... of climate change could affect civil conflicts. The team ... socio-economic conditions and climate. They will use these to ... U.S. Department of Defense is funding the research through ...
Cached Biology News:New study shows predators affect the carbon cycle 2Submarine springs reveal how coral reefs respond to ocean acidification 2DoD-funded research: Can climate change heat up conflict? 2
(Date:7/31/2014)... 31, 2014 CollabRx, Inc. (NASDAQ: CLRX), ... decision-making in oncology, today announced that it will hold ... discuss the Company's financial results for the first quarter ... the business in the current fiscal year. , The ... Thursday, August 14, 2014, at 5 p.m. EDT (2 ...
(Date:7/31/2014)... 2014  Smith & Nephew (LSE:SN, NYSE: ... today announced its entry into the forefoot market ... Repair System. Comprised of three separate repair options, ... ligament repair and reconstruction, a metatarsal osteotomy guide, ... (PIP) fusion, also known as hammer toe correction. ...
(Date:7/31/2014)... Held at the Stanford Cancer Center, ... of the disease and its treatment. Survivors will find ... well as updates on the state-of-the-art with respect to ... for organizing this educational opportunity,” says KCA CEO Bill ... her colleagues have put together a program that balances ...
(Date:7/31/2014)... The global market for molecular diagnostics ... according to a new study by Grand View Research, ... the subsequent introduction of advanced cancer diagnostic technologies are ... the next six years. Moreover, the growing global base ... coupled with disease triggering lifestyle habits such as smoking ...
Breaking Biology Technology:CollabRx, Inc. Schedules First Quarter Fiscal Year 2015 Financial Conference Call and Business Update 2Smith & Nephew scores a HAT-TRICK with its entry into the high-growth hammer toe repair market 2Smith & Nephew scores a HAT-TRICK with its entry into the high-growth hammer toe repair market 3Smith & Nephew scores a HAT-TRICK with its entry into the high-growth hammer toe repair market 4Molecular Diagnostics Market - Global Industry Size, Share, Trends, Analysis, Players, Opportunity, Outlook and Forecast From 2014 to 2020 2Molecular Diagnostics Market - Global Industry Size, Share, Trends, Analysis, Players, Opportunity, Outlook and Forecast From 2014 to 2020 3Molecular Diagnostics Market - Global Industry Size, Share, Trends, Analysis, Players, Opportunity, Outlook and Forecast From 2014 to 2020 4Molecular Diagnostics Market - Global Industry Size, Share, Trends, Analysis, Players, Opportunity, Outlook and Forecast From 2014 to 2020 5
... AURORA, Ontario, June 19 Helix BioPharma Corp. (TSX, ... scientific officer at Helix BioPharma Corp., will be presenting ... at the 2009 American Association of Pharmaceutical Scientists ("AAPS") ... 24th at the Washington State Convention and Trade Center ...
... BEIJING, June 19 /PRNewswire-Asia/ -- Sinovac Biotech Ltd.,(NYSE ... of vaccines in China,announced today that the Company received the ... to the Beijing government. The initial order,consists of 4 million ... of,September. This order will be administered to 2 million ...
... and efficacy of Albuferon administered every four weeks in combination ... C - , , ROCKVILLE, Md., June 19 ... announced that Novartis has completed enrollment and initial dosing in ... efficacy of Albuferon(R) (albinterferon alfa-2b) administered monthly in combination with ...
Cached Biology Technology:Helix BioPharma to Present L-DOS47 Analytical Method Development Findings at 2009 AAPS National Biotechnology Conference 2Helix BioPharma to Present L-DOS47 Analytical Method Development Findings at 2009 AAPS National Biotechnology Conference 3Helix BioPharma to Present L-DOS47 Analytical Method Development Findings at 2009 AAPS National Biotechnology Conference 4Helix BioPharma to Present L-DOS47 Analytical Method Development Findings at 2009 AAPS National Biotechnology Conference 5Sinovac Receives China's First Influenza A (H1N1) Vaccine Order 2Sinovac Receives China's First Influenza A (H1N1) Vaccine Order 3Human Genome Sciences Announces Completion of Enrollment in Phase 2b Monthly-Dosing Trial of Albuferon(R) 2Human Genome Sciences Announces Completion of Enrollment in Phase 2b Monthly-Dosing Trial of Albuferon(R) 3Human Genome Sciences Announces Completion of Enrollment in Phase 2b Monthly-Dosing Trial of Albuferon(R) 4
...
... is undoubtedly the most complete and professional ... of layers and subsets makes it is ... different data outputs, for example Cy3 and ... well as different subsets of genes and/or ...
...
...
Biology Products: