Navigation Links
Discovery could yield treatment for cocaine addicts
Date:3/15/2013

EAST LANSING, Mich. --- Scientists have discovered a molecular process in the brain triggered by cocaine use that could provide a target for treatments to prevent or reverse addiction to the drug.

Reporting in the Journal of Neuroscience, Michigan State University neuroscientist A.J. Robison and colleagues say cocaine alters the nucleus accumbens, the brain's pleasure center that responds to stimuli such as food, sex and drugs.

"Understanding what happens molecularly to this brain region during long-term exposure to drugs might give us insight into how addiction occurs," said Robison, assistant professor in the Department of Physiology and the Neuroscience Program.

The researchers found that cocaine causes cells in the nucleus accumbens to boost production of two proteins, one associated with addiction and the other related to learning. The proteins have a reciprocal relationship -- they increase each other's production and stability in the cells -- so the result is a snowball effect that Robison calls a feed-forward loop.

Robison and colleagues demonstrated that loop's essential role in cocaine responses by manipulating the process in rodents. They found that raising production of the protein linked to addiction made animals behave as if they were exposed to cocaine even when they weren't. They also were able to break the loop, disrupting rodents' response to cocaine by preventing the function of the learning protein.

"At every level that we study, interrupting this loop disrupts the process that seems to occur with long-term exposure to drugs," said Robison, who conducted the study as a postdoctoral fellow at Mount Sinai School of Medicine in New York City before joining the faculty at MSU.

Robison said the study was particularly compelling because it found signs of the same feed-forward loop in the brains of people who died while addicted to cocaine.

"The increased production of these proteins
'/>"/>

Contact: Andy McGlashen
andy.mcglashen@cabs.msu.edu
517-355-5158
Michigan State University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Discovery may explain how prion diseases spread between different types of animals
2. Gene discovery reveals importance of eating your greens
3. IU discovery on animal memory opens doors to research on memory impairment diseases
4. Cell discovery could hold key to causes of inherited diseases
5. New scorpion discovery near metropolitan Tucson, Arizona
6. The discovery of a new genus of crustacean and 5 new species
7. A*STAR scientists groundbreaking discovery of nucleus structure crucial to understanding diseases
8. Discovery of sexual mating in Candida albicans could provide insights into infections
9. New discovery in autism-related disorder reveals key mechanism in brain development and disease
10. Discovery of Africa moth species important for agriculture, controlling invasive plants
11. Discovery may pave way to genetically enhanced biofuel crops
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/6/2015)... Calif. , Aug. 6, 2015 ... developer of human interface solutions, today announced collaboration ... technologies on Windows 10. Microsoft leveraged Synaptics, deep ... the operating system. Through stringent ... are fully certified with Microsoft,s Precision TouchPad (PTP) ...
(Date:8/5/2015)... August 5, 2015 Transparency Market ... Recognition Market - Global Industry Analysis, Size, Share, Growth, ... for facial recognition is forecast to reach US$ 2,671.8 ... demand for surveillance systems by civil and government agencies. ... crimes and terrorist activities across the globe that would ...
(Date:8/4/2015)... 04, 2015 ... announced the addition of the "Digital ... Service), Sub-Segment (Computer Forensics, Network Forensics, Mobile ... Service, Vertical and Region - Global Forecast ... By Component (Hardware, Software, and ...
Breaking Biology News(10 mins):Synaptics Chosen for Human Interface Co-Development on Windows 10 2Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 2Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 3Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 4Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 5Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 6Digital Forensics Market - The Market Represents a Compound Annual Growth Rate (CAGR) of 11.3% From 2015 to 2020 2
... retailer of wine products, BRSM Sales LLC, today announced the ... holiday shopping: www.GreatWineProducts.com . The new ... products including but not limited to: glass and stemware, burlap ... In addition to personal use, many items make ...
... the fight against pneumonia is the focus of ... University ePress., With an aim to establish an ... ,is a peer-reviewed, open-access journal which brings together ... Griffith,s Professor Allan Cripps is the Editor in ...
... 2013 New data suggest that the transcription ... Researchers determined that alcohol given to mice deficient ... alcoholic hepatitis. Further they found that although hepatitis ... in combination they suppressed FOXO3, reduced expression of ...
Cached Biology News:Griffith joins the fight against pneumonia 2Transcription factor may protect against hepatic injury caused by hepatitis C and alcohol 2Transcription factor may protect against hepatic injury caused by hepatitis C and alcohol 3
(Date:9/2/2015)... ... September 02, 2015 , ... The TS5-Q ... professional commercial video content, to analysis of athletic performance. Producing high-resolution slow-motion ... by too quickly to process with the naked eye. , Slow motion ...
(Date:9/1/2015)... ... September 02, 2015 , ... Spirax Sarco , the leader in products ... Spirax Sarco Anytime. This platform, offering unique online ordering capabilities, is only available ... Log on to Spirax Sarco Anytime and within minutes you can be making ...
(Date:9/1/2015)... , Sept. 1, 2015 Prostate ... death in American men. One in seven ... 233,000 new cases are diagnosed annually. That said, ... using a powerful new technique, MRI Fusion Biopsy, ... large cancer lesions, treating only the affected areas ...
(Date:9/1/2015)... ... September 01, 2015 , ... ... announced today that the National Institutes of Health (NIH) has awarded the company ... administered by the NIH’s National Institute of Diabetes and Digestive and Kidney Diseases. ...
Breaking Biology Technology:Fastec Introduces the Quad-HD TS5-Q High-Speed Camera 2Fastec Introduces the Quad-HD TS5-Q High-Speed Camera 3Spirax Sarco Announces New Features to Anytime Platform 2September Is Prostate Cancer Awareness Month 2September Is Prostate Cancer Awareness Month 3September Is Prostate Cancer Awareness Month 4AxioMx Announces Receipt of SBIR Grant for DNA-Protein Complex Antigen Development 2AxioMx Announces Receipt of SBIR Grant for DNA-Protein Complex Antigen Development 3
... Lentigen Corporation announced today,that it has received ... research (SBIR) grants to collaborate with leading,scientists. Through ... (LV) technology to the development of novel,immunotherapeutic treatments ... -- Melanoma, with Michael Nishimura, Ph.D, Associate ...
... 15 Baxa Corporation, a,Denver-based manufacturer of medical ... Marketing Association Gold Key Awards for its,integrated direct ... Colorado,s most highly acclaimed marketing competitions, the BMA,Gold ... on May 3rd at the,Cable Center at the ...
... a leading life sciences company, announced today that the ... Executive Officer,and a member of the Cambrex Corporation Board ... and Chief Executive Officer since 1995,and Chairman since 1999, ... the positions of Board Chairman and CEO and John ...
Cached Biology Technology:Lentigen Corporation Receives Four Research Grants From the National Institutes of Health 2Baxa Corporation Wins Two Colorado BMA 2008 Gold Key Awards 2Baxa Corporation Wins Two Colorado BMA 2008 Gold Key Awards 3Cambrex Appoints Steven M. Klosk as President and CEO 2
... uptake of long double stranded RNA (dsRNA) ... in a diverse group of organisms as ... interference leads to the inhibition of protein ... the target messenger RNA (mRNA). Attempts to ...
... Powerful exact mass measurements in ... orthogonal electrospray time-of-flight mass spectrometer (ESI-oa-TOF) ... machine in a format, which fits ... a mass resolution exceeding 10,000 FWHM ...
... Performance The TSQ Quantum Ultra defines ... bioanalytical and environmental analysis. It features ... APCI probes, a titanium skimmer with superior ... and sensitivity. Its redesigned ion transfer ...
... of long double stranded RNA (dsRNA) has ... a diverse group of organisms as well ... leads to the inhibition of protein expression ... target messenger RNA (mRNA). Attempts to induce ...
Biology Products: