Navigation Links
Discovery could yield treatment for cocaine addicts
Date:3/15/2013

EAST LANSING, Mich. --- Scientists have discovered a molecular process in the brain triggered by cocaine use that could provide a target for treatments to prevent or reverse addiction to the drug.

Reporting in the Journal of Neuroscience, Michigan State University neuroscientist A.J. Robison and colleagues say cocaine alters the nucleus accumbens, the brain's pleasure center that responds to stimuli such as food, sex and drugs.

"Understanding what happens molecularly to this brain region during long-term exposure to drugs might give us insight into how addiction occurs," said Robison, assistant professor in the Department of Physiology and the Neuroscience Program.

The researchers found that cocaine causes cells in the nucleus accumbens to boost production of two proteins, one associated with addiction and the other related to learning. The proteins have a reciprocal relationship -- they increase each other's production and stability in the cells -- so the result is a snowball effect that Robison calls a feed-forward loop.

Robison and colleagues demonstrated that loop's essential role in cocaine responses by manipulating the process in rodents. They found that raising production of the protein linked to addiction made animals behave as if they were exposed to cocaine even when they weren't. They also were able to break the loop, disrupting rodents' response to cocaine by preventing the function of the learning protein.

"At every level that we study, interrupting this loop disrupts the process that seems to occur with long-term exposure to drugs," said Robison, who conducted the study as a postdoctoral fellow at Mount Sinai School of Medicine in New York City before joining the faculty at MSU.

Robison said the study was particularly compelling because it found signs of the same feed-forward loop in the brains of people who died while addicted to cocaine.

"The increased production of these proteins
'/>"/>

Contact: Andy McGlashen
andy.mcglashen@cabs.msu.edu
517-355-5158
Michigan State University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Discovery may explain how prion diseases spread between different types of animals
2. Gene discovery reveals importance of eating your greens
3. IU discovery on animal memory opens doors to research on memory impairment diseases
4. Cell discovery could hold key to causes of inherited diseases
5. New scorpion discovery near metropolitan Tucson, Arizona
6. The discovery of a new genus of crustacean and 5 new species
7. A*STAR scientists groundbreaking discovery of nucleus structure crucial to understanding diseases
8. Discovery of sexual mating in Candida albicans could provide insights into infections
9. New discovery in autism-related disorder reveals key mechanism in brain development and disease
10. Discovery of Africa moth species important for agriculture, controlling invasive plants
11. Discovery may pave way to genetically enhanced biofuel crops
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2014)... 20, 2014 George E. Fox, a John and Rebecca ... Houston (UH), was named a fellow in the International Society ... , Fox is one of four members two from ... chosen as fellows in 2014. Fellows are elected every three ... than 500 members from more than 20 countries, the ISSOL ...
(Date:8/20/2014)... Institute (HCI) at the University of Utah have identified ... BCR-ABL, the unregulated enzyme driving the blood cancer chronic ... nearly 6,000 new cases of CML will be diagnosed ... kinase inhibitors (TKIs), target BCR-ABL and are effective at ... control it in a way that allows patients to ...
(Date:8/20/2014)... /CNW/ -  Issue Serious allergic reactions ... life threatening for some children.    What you ... have food allergies and this number may be increasing, especially ... estimated to have food allergies.  The symptoms ... hives to breathing difficulties and loss of consciousness. Symptoms can ...
Breaking Biology News(10 mins):UH professor named fellow by International Astrobiology Society 2Blueprint for next generation of chronic myeloid leukemia treatment 2Information Update - Allergens and food safety at school - What's in your child's lunch? 2Information Update - Allergens and food safety at school - What's in your child's lunch? 3
... an avian influenza vaccine with doses as low as ... mixture known as MF59. The research is published in ... available online. , MF 59 is an adjuvant--a ... to a stimulus. For this research, the investigators used ...
... made international headlines in May 2006 when Colin Watson, ... after falling from a 12-meter tree, allegedly while hunting ... of Birds estimates that up to 30 of Britain's ... theory predicts that such exploitation is unlikely to extinguish ...
... C virus turns on human immune defenses upon entering ... manipulating interaction of key cellular proteins, UT Southwestern Medical ... "on/off switch" controls immunity against many viruses, highlighting a ... the researchers report. , In a study available ...
Cached Biology News:A human taste for rarity spells disaster for endangered species 2A human taste for rarity spells disaster for endangered species 3Molecular 'on/off switch' controls immune defenses against viruses 2
(Date:8/21/2014)... 21, 2014 ... announced the addition of the  "Global Hormone ... offering.       (Logo: http://photos.prnewswire.com/prnh/20130307/600769) ,Hormone ... is a means of replacing hormones that ... body. This type of therapy is usually ...
(Date:8/21/2014)... Rochelle, N.Y. (PRWEB) August 21, 2014 ... is the first private college in the Mid-Hudson Region ... College will now begin accepting applications from qualified “high-technology” ... , “We are very pleased to have been selected ... support Governor Cuomo’s transformative initiative to stimulate economic development ...
(Date:8/21/2014)... OTC Markets Group Inc. ... company, on its approval to list on The ... the best marketplace for established U.S. and global ... Logo - http://photos.prnewswire.com/prnh/20110118/MM31963LOGO "We ... its growth strategy and achievement of this important ...
(Date:8/21/2014)... Pursuit Solutions ( http://www.pursuit-solutions.com ), a ... for Life Sciences sales and marketing organizations, announced ... Commercial Sales Models” by Peter Robinson, co-founder and ... examines some innovative models used to improve sales ... the pharmaceutical market. Robinson grades the industry on ...
Breaking Biology Technology:Global Hormone Replacement Therapy Market 2014-2018: Key Vendors are Actavis, Bayer, Merck & Co, Novartis and Novo Nordisk 2The College of New Rochelle Becomes First Private College in Mid-Hudson Region to Earn START-UP NY Designation 2The College of New Rochelle Becomes First Private College in Mid-Hudson Region to Earn START-UP NY Designation 3OTC Markets Group Congratulates Immune Pharmaceuticals on NASDAQ Listing 2Pursuit's Peter Robinson Publishes "Grading Pharma's Use of New Commercial Sales Models" 2
... Cephalon, Inc. (Nasdaq:,CEPH) announced today that the presentation ... JPMorgan Healthcare Conference are now available on the,"Investor Information" ... Tuesday, January 8, 2008, Frank Baldino, Jr.,Ph.D., Chairman and ... beginning at 2:00 p.m. Pacific Time (5 p.m. Eastern ...
... Staff to Continue Record of Investment Success -, ... operationally,independent worldwide biologics unit of AstraZeneca plc (LSE: ... venture capital fund,MedImmune Ventures, will broaden its focus ... by adding the therapeutic areas of,cardiovascular and metabolic ...
... With the SEC Shares Expected to ... HAMBURG, Germany and OXFORD, England, January 7 /PRNewswire-FirstCall/,--, ... Adjustments of,Evotec,s Consolidated Financial Statements With a Positive Net ... September 30 2007, Evotec AG (Frankfurt Stock Exchange: ...
Cached Biology Technology:Cephalon Presentation Slides for the 26th Annual JPMorgan Healthcare Conference Now Available 2MedImmune Broadens Focus of Venture Capital Fund to Include New Therapeutic Areas 2MedImmune Broadens Focus of Venture Capital Fund to Include New Therapeutic Areas 3Evotec Provides Update on Planned NASDAQ Listing in the Context of its Announced Acquisition of Renovis 2Evotec Provides Update on Planned NASDAQ Listing in the Context of its Announced Acquisition of Renovis 3Evotec Provides Update on Planned NASDAQ Listing in the Context of its Announced Acquisition of Renovis 4Evotec Provides Update on Planned NASDAQ Listing in the Context of its Announced Acquisition of Renovis 5
5(S)-HETE-d8 is used as an internal standard for the quantification of 5(S)-HETE by stable isotope dilution mass spectrometry....
Full-length cDNA clone CS0DJ013YG01 of T cells (Jurkat cell line) of Homo sapiens (human). [Source:Uniprot/SPTREMBL;Acc:Q86SZ3] Antigen: Recombinant Protein Epitope Signature Tag (PrEST)....
...
...
Biology Products: