Navigation Links
Discovery at JGH opens door to new treatments for prostate, brain and skin cancers
Date:1/7/2010

This release is available in French.

Researchers at the Lady Davis Institute for Medical Research of the Jewish General Hospital and McGill University in Montreal have discovered a previously unsuspected link between two different genetic pathways which suppress the growth of cancer tumours. This breakthrough, they say, could lead to new treatments for some of the deadliest and most intractable forms of cancer; including prostate cancer, brain cancer and melanoma.

The scientists discovered a novel link between a tumour-suppressing gene known as the phosphatase and tensin homolog (PTEN) and a protein called PKR, which is known to inhibit protein synthesis. The researchers discovered that when PTEN is mutated or absent, PKR loses its inhibitory ability, and protein synthesis within the affected cells runs wild.

"This leads to high proliferation of cells with a survival advantage over normal cells," explains Dr. Antonis E. Koromilas of the JGH Lady Davis Institute for Medical Research and McGill's Department of Oncology. "That is a condition that facilitates tumour development."

PTEN plays a vital role in the suppression of humans cancers by inhibiting a genetic pathway called phosphoinositide-3 kinase (PI3K). Clinicians often target PI3K with drugs when treating cancer patients, but this does not work in all cases, because not all mutant forms of PTEN interact with PI3K. In 1992, in a study published in the journal Science, Dr. Koromilas and Dr. Nahum Sonenberg of McGill University identified PKR as a potential tumour suppressor, but its association with PTEN was unsuspected at the time.

The new discovery was made by Koromilas's graduate researcher Zineb Mounir, the study's first author, along with colleagues in the United States. Their findings were published December 22 in the journal Science Signalling.

'/>"/>
Contact: Mark Shainblum
mshainblum@jgh.mcgill.ca
514-340-8222 x6592
Jewish General Hospital
Source:Eurekalert

Page: 1 2

Related biology news :

1. Discovery of a new molecular mechanism that guides visual nerves towards the brain
2. New discovery by Harvard scientists aims to correct cellular defects leading to diabetes
3. New year, new vitamin C discovery: It cures mice with accelerated aging disease
4. Emerald BioStructures announces discovery of small molecule modulators of PDE4
5. UGA researchers lead team in discovery involving devastating freshwater fish parasite, Ich
6. Discovery makes brain tumor cells more responsive to radiation
7. Discovery of the Jekyll-and-Hyde factors in coral bleaching
8. Rocket science leads to new whale discovery
9. A year after discovery, Congos mother lode of gorillas remains vulnerable
10. Cancer metabolism discovery uncovers new role of IDH1 gene mutation in brain cancer
11. Its a gas: New discovery may lead to heartier, high-yielding plants
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/19/2014)... Oklahoma biology professor will study the unique bioelectric signaling ... eventually benefit people,s health. The OU researcher is ... required to produce the signals used to map the ... at a rate of 500-600 discharges a second throughout ... electric fish are extreme, but necessary for survival. , ...
(Date:9/19/2014)... of fairness did not evolve for the sake of ... benefits of continued cooperation, so say Frans de Waal, ... article about inequity aversion (IA), which is defined as ... published in Science . , Their conclusion ... studies to address their hypothesis that it is the ...
(Date:9/19/2014)... 2014 Nxt-ID, Inc. (Nasdaq: NXTD and ... the growing m-commerce market, updates the "Wocket in Your Pocket" celebrity ... and light middleweight weight classes, Vinny Pazienza (PAZ). ... Game of Thrones actor Ciaran Hinds and ... star Katey Sagal have been cast in Bleed ...
Breaking Biology News(10 mins):Evolution of responses to (un)fairness 2Evolution of responses to (un)fairness 3NXT-ID's Vinny Paz Celebrity Ad Wocket Update: Katey Sagal and Ciaran Hinds Attached to His Upcoming Movie 2NXT-ID's Vinny Paz Celebrity Ad Wocket Update: Katey Sagal and Ciaran Hinds Attached to His Upcoming Movie 3
... them get psyched up for contests, but when these ... gobble down before and during events, they could be ... treatments for the symptoms of an injury, not the ... University focuses on musculoskeletal health and sports medicine. "They ...
... A University of Maryland School of Medicine researcher will ... nation,s most prominent scientists in the field of stem ... and Preventive Medicine, was chosen by the National Heart, ... of this consortium of national experts, which will be ...
... , , ... Dec. 2 Communication Intelligence Corporation ("CIC") (OTC Bulletin ... for business process automation in the financial industry* and ... Systems Inc. ("Docubase"), a leading International Electronic Document Management ...
Cached Biology News:NSAIDs: Take 'em early and often when competing? Think again 2University of Maryland School of Medicine receives $30 million to coordinate stem cell consortium 2University of Maryland School of Medicine receives $30 million to coordinate stem cell consortium 3CIC Teams with Docubase Systems to Deliver eSignature Enabled Document Management Solutions 2CIC Teams with Docubase Systems to Deliver eSignature Enabled Document Management Solutions 3CIC Teams with Docubase Systems to Deliver eSignature Enabled Document Management Solutions 4
(Date:9/19/2014)... 2014 Follow us on ... revolutionize the world has attracted diverse players including ... start-ups. The early years of nanotechnology development was ... to the high risks involved, which deterred private ... this evolving technology have been growing over the ...
(Date:9/19/2014)... -- Pfenex Inc. (NYSE MKT: PFNX), a clinical-stage biotechnology ... to manufacture proteins including biosimilar therapeutics, today announced that ... Annual NewsMakers in the Biotech Industry conference in ... chief executive officer of Pfenex, will provide an overview ... Friday, September 26, 2014 at 10:00 a.m. EDT/7:00 a.m. ...
(Date:9/19/2014)... , September 19, 2014 ... Markets ( http://www.researchandmarkets.com/research/b2jxhs/micro_market ) has announced the addition of ... Columns"  report to their offering.       ... is one of the fastest-growing segments in the ... billion in 2013, and expected to reach $2.0 ...
(Date:9/18/2014)... (PRWEB) September 18, 2014 ... urological and interventional radiology products and services, announced ... as cryotherapy and cryoablation) versus external beam radiotherapy ... of the American Urological Association (MAAUA) Annual Meeting ... "Comparing Relative Effectiveness of Cryosurgery and External Beam ...
Breaking Biology Technology:Growing R&D Investments & Developments in Nanomaterials to Drive the Global Nanotechnology Market, According to New Report by Global Industry Analysts, Inc. 2Growing R&D Investments & Developments in Nanomaterials to Drive the Global Nanotechnology Market, According to New Report by Global Industry Analysts, Inc. 3Growing R&D Investments & Developments in Nanomaterials to Drive the Global Nanotechnology Market, According to New Report by Global Industry Analysts, Inc. 4Pfenex to Present at Upcoming Industry Conference on September 26 2Micro Market Monitor : Global Pre-packed Chromatography Columns 2HealthTronics Announces Data Comparing Cryotherapy Versus Radiation for Treating Prostate Cancer Poster Presented at the American Urological Association Regional Meeting 2
... Jan. 28 Ther-Rx Corporation, a,subsidiary of KV ... KV Pharmaceutical Company on January 26, 2009, a ... lots within,expiration) as a precautionary measure because they ... sufficiently comply with current Good,Manufacturing Practices (cGMPs). , ...
... Product is Japan,s first second-generation drug-eluting stentNATICK, Mass., ... BSX ) announced today that it has ... Labor and Welfare (MHLW) to market its TAXUS(R) ... plans to launch the product as soon as ...
... NOVATO, Calif., Jan. 28 BioMarin Pharmaceutical,Inc. (Nasdaq: ... BioMarin, will host a conference call and webcast on,Wednesday, February ... quarter,and full year 2008 financial results. , , ... International Dial-in Number: 617.213.8835, Participant ...
Cached Biology Technology:Ther-Rx Corporation Issues Nationwide Voluntary Recall of Products 2Boston Scientific Announces Japanese Approval for TAXUS(R) Liberte(R) Drug-Eluting Stent System 2Boston Scientific Announces Japanese Approval for TAXUS(R) Liberte(R) Drug-Eluting Stent System 3BioMarin to Host Fourth Quarter and Full Year 2008 Financial Results Conference Call and Webcast on Wednesday, February 18 at 5:00 p.m. ET (23:00 CET) 2
... These skirted micro test tubes are ... of polypropylene, these tubes have uniform walls ... nonsterile, with separate O-ring screw caps. The ... and have an operating range from -55 ...
Caspr2 Antigen: Fusion protein amino acids 96-1265 (extracellular domain) of human Caspr2 Accession Number: NP_054860...
... to introduce its new line of Protein ... proteins for use in mass spectrometry, molecular ... Protein Standards are high quality purified proteins ... analyses by electrospray ionization mass spectrometry (ESI-MS). ...
Determin interaction of your protein with Echelons lipids...
Biology Products: