Navigation Links
Discovery at JGH opens door to new treatments for prostate, brain and skin cancers
Date:1/7/2010

This release is available in French.

Researchers at the Lady Davis Institute for Medical Research of the Jewish General Hospital and McGill University in Montreal have discovered a previously unsuspected link between two different genetic pathways which suppress the growth of cancer tumours. This breakthrough, they say, could lead to new treatments for some of the deadliest and most intractable forms of cancer; including prostate cancer, brain cancer and melanoma.

The scientists discovered a novel link between a tumour-suppressing gene known as the phosphatase and tensin homolog (PTEN) and a protein called PKR, which is known to inhibit protein synthesis. The researchers discovered that when PTEN is mutated or absent, PKR loses its inhibitory ability, and protein synthesis within the affected cells runs wild.

"This leads to high proliferation of cells with a survival advantage over normal cells," explains Dr. Antonis E. Koromilas of the JGH Lady Davis Institute for Medical Research and McGill's Department of Oncology. "That is a condition that facilitates tumour development."

PTEN plays a vital role in the suppression of humans cancers by inhibiting a genetic pathway called phosphoinositide-3 kinase (PI3K). Clinicians often target PI3K with drugs when treating cancer patients, but this does not work in all cases, because not all mutant forms of PTEN interact with PI3K. In 1992, in a study published in the journal Science, Dr. Koromilas and Dr. Nahum Sonenberg of McGill University identified PKR as a potential tumour suppressor, but its association with PTEN was unsuspected at the time.

The new discovery was made by Koromilas's graduate researcher Zineb Mounir, the study's first author, along with colleagues in the United States. Their findings were published December 22 in the journal Science Signalling.

'/>"/>
Contact: Mark Shainblum
mshainblum@jgh.mcgill.ca
514-340-8222 x6592
Jewish General Hospital
Source:Eurekalert

Page: 1 2

Related biology news :

1. Discovery of a new molecular mechanism that guides visual nerves towards the brain
2. New discovery by Harvard scientists aims to correct cellular defects leading to diabetes
3. New year, new vitamin C discovery: It cures mice with accelerated aging disease
4. Emerald BioStructures announces discovery of small molecule modulators of PDE4
5. UGA researchers lead team in discovery involving devastating freshwater fish parasite, Ich
6. Discovery makes brain tumor cells more responsive to radiation
7. Discovery of the Jekyll-and-Hyde factors in coral bleaching
8. Rocket science leads to new whale discovery
9. A year after discovery, Congos mother lode of gorillas remains vulnerable
10. Cancer metabolism discovery uncovers new role of IDH1 gene mutation in brain cancer
11. Its a gas: New discovery may lead to heartier, high-yielding plants
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/16/2014)... they are anything but sustainable: environmental damage to ... becoming increasingly evident. Despite their disadvantages, however, monocultures ... as the sole possibility of achieving higher yields ... Schmid, an ecology professor at the University of ... and forestry. After all, a new study carried ...
(Date:10/16/2014)... Calif. (October 16, 2014) – Post-menopausal women experienced ... on hormone levels or genital bleeding, after 12 ... an investigational fermented soy germ-based nutritional supplement previously ... to a new peer-reviewed pilot study reported in ... (NAMS) annual scientific meeting. , "These data ...
(Date:10/15/2014)... N.Y. , Oct. 15, 2014 ... solutions for home and community-based care, today announced ... of implementing Sandata,s Santrax® Electronic Visit Verification™ Solution ... Services is a home health company founded in ... Texas . The study ...
Breaking Biology News(10 mins):Plant communities produce greater yield than monocultures 2Plant communities produce greater yield than monocultures 3S-equol supplements associated with improved measures of reproductive health in postmenopausal women 2Sandata Announces Case Study with Quality Care Services, Inc. 2
... CHAPEL HILL, N.C. A new study led by ... differences in brain development starting at age 6 months in ... who did not develop autism. "It,s a promising finding," ... and a postdoctoral fellow at UNC,s Carolina Institute for Developmental ...
... & Science University have discovered that brain cells ... critically important for the growth of brainstem neurons responsible ... the prevention and treatment of SIDS (Sudden Infant Death ... one month to one year. The new ...
... MADISON -- Nacre -- or mother of pearl, scientists and ... Produced by a multitude of mollusk species, nacre is ... musical instruments, furniture and decorative boxes. Fashioned into buttons, beads ... mother of pearl lends a lustrous iridescence to everyday objects. ...
Cached Biology News:Brain-imaging differences evident at 6 months in infants who develop autism 2OHSU discovery may someday lead to prevention and treatment of sudden infant death syndrome 2Mother of pearl tells a tale of ocean temperature, depth 2
(Date:10/19/2014)... The report "Unmanned Ground Vehicle Market by ... Type & by Geography - Forecasts & Analysis ... vehicle market into various sub segments with an ... report also identifies the factors driving this market, ... the adoption trends. , The unmanned ground vehicle ...
(Date:10/18/2014)... The Asian arthroscopic devices report defines and segments ... of revenue. The arthroscopic devices market in Asia is ... a CAGR of 6.5% from 2013 to 2018. , ... market, to get an idea of the in-depth analysis ... of arthroscopic devices market in the same region, and ...
(Date:10/18/2014)... According to a new market research report “Hydraulic ... Trends & Forecasts up till 2017”, hydraulic fracturing market ... value is expected to increase from $40 billion in ... during the same period. North America is expected to ... of hydraulic horse power supplied by the year 2011. ...
(Date:10/17/2014)... Germany , October 17, 2014 ... Translational research in cancer and other diseases will ... American Society of Human Genetics annual meeting   ... to Ingenuity ®  Knowledge Base greatly exceeds any ... Ingenuity ®  Variant Analysis™ adds fully integrated ...
Breaking Biology Technology:Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 2Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 3Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 4Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 5The Asian arthroscopic devices market is estimated to grow to $712.3 million by 2018 - New Report by MicroMarket Monitor 2The Asian arthroscopic devices market is estimated to grow to $712.3 million by 2018 - New Report by MicroMarket Monitor 3The Asian arthroscopic devices market is estimated to grow to $712.3 million by 2018 - New Report by MicroMarket Monitor 4Hydraulic Fracturing Market Projected To Reach $64 Billion by 2017 - New Report by MarketsandMarkets 2Hydraulic Fracturing Market Projected To Reach $64 Billion by 2017 - New Report by MarketsandMarkets 3Hydraulic Fracturing Market Projected To Reach $64 Billion by 2017 - New Report by MarketsandMarkets 4QIAGEN Demonstrates Expanded Bioinformatics Workflows at ASHG; Strong Market Adoption as Researchers Analyze Genomic Data on More Than a Quarter-Million Samples in Secure Private Cloud 2QIAGEN Demonstrates Expanded Bioinformatics Workflows at ASHG; Strong Market Adoption as Researchers Analyze Genomic Data on More Than a Quarter-Million Samples in Secure Private Cloud 3QIAGEN Demonstrates Expanded Bioinformatics Workflows at ASHG; Strong Market Adoption as Researchers Analyze Genomic Data on More Than a Quarter-Million Samples in Secure Private Cloud 4QIAGEN Demonstrates Expanded Bioinformatics Workflows at ASHG; Strong Market Adoption as Researchers Analyze Genomic Data on More Than a Quarter-Million Samples in Secure Private Cloud 5QIAGEN Demonstrates Expanded Bioinformatics Workflows at ASHG; Strong Market Adoption as Researchers Analyze Genomic Data on More Than a Quarter-Million Samples in Secure Private Cloud 6
... Keryx Biopharmaceuticals,Inc. (Nasdaq: KERX ) today ... will present an overview of the Company,s cancer,pipeline ... Investment Conference,in San Francisco. Dr. Henderson,s presentation will ... PT. Dr. Henderson,s presentation will be webcast ...
... Mass., Sept. 17 Interleukin Genetics,(Amex: ILI ... Scientific,Officer, Kenneth Kornman, DDS, PhD, will present at ... Alexandria, VA. The conference will,focus on innovative methods ... Among a group of presenters that includes industry ...
... the U.S. Department of Energy,s Argonne National Laboratory physicist ... mechanisms, which makes it possible to switch a magnetic ... to more accurately write and store information. , Bode ... a special scanning tunneling microscope equipped with a magnetic ...
Cached Biology Technology:Keryx Biopharmaceuticals to Present at Bank of America Investment Conference 2Interleukin Genetics President and Chief Scientific Officer to Present at Immunotoxicology V Conference 2Interleukin Genetics President and Chief Scientific Officer to Present at Immunotoxicology V Conference 3Researchers improve ability to write and store information on electronic devices 2
Gloves are 9.25 long, latex, powder free, smooth and ambidextrous....
Request Info...
Prepared with distilled water. Yeast extract solution is autolyzed at 150 g/L....
Streptomycin sulfate an aminoglycoside used for bacterial selection binds to the small ribosomal subunit and interferes with protein biosynthesis.21H39N7O12)2x3H2SO4Formula weight:...
Biology Products: