Navigation Links
Discovery at JGH opens door to new treatments for prostate, brain and skin cancers
Date:1/7/2010

This release is available in French.

Researchers at the Lady Davis Institute for Medical Research of the Jewish General Hospital and McGill University in Montreal have discovered a previously unsuspected link between two different genetic pathways which suppress the growth of cancer tumours. This breakthrough, they say, could lead to new treatments for some of the deadliest and most intractable forms of cancer; including prostate cancer, brain cancer and melanoma.

The scientists discovered a novel link between a tumour-suppressing gene known as the phosphatase and tensin homolog (PTEN) and a protein called PKR, which is known to inhibit protein synthesis. The researchers discovered that when PTEN is mutated or absent, PKR loses its inhibitory ability, and protein synthesis within the affected cells runs wild.

"This leads to high proliferation of cells with a survival advantage over normal cells," explains Dr. Antonis E. Koromilas of the JGH Lady Davis Institute for Medical Research and McGill's Department of Oncology. "That is a condition that facilitates tumour development."

PTEN plays a vital role in the suppression of humans cancers by inhibiting a genetic pathway called phosphoinositide-3 kinase (PI3K). Clinicians often target PI3K with drugs when treating cancer patients, but this does not work in all cases, because not all mutant forms of PTEN interact with PI3K. In 1992, in a study published in the journal Science, Dr. Koromilas and Dr. Nahum Sonenberg of McGill University identified PKR as a potential tumour suppressor, but its association with PTEN was unsuspected at the time.

The new discovery was made by Koromilas's graduate researcher Zineb Mounir, the study's first author, along with colleagues in the United States. Their findings were published December 22 in the journal Science Signalling.

'/>"/>
Contact: Mark Shainblum
mshainblum@jgh.mcgill.ca
514-340-8222 x6592
Jewish General Hospital
Source:Eurekalert

Page: 1 2

Related biology news :

1. Discovery of a new molecular mechanism that guides visual nerves towards the brain
2. New discovery by Harvard scientists aims to correct cellular defects leading to diabetes
3. New year, new vitamin C discovery: It cures mice with accelerated aging disease
4. Emerald BioStructures announces discovery of small molecule modulators of PDE4
5. UGA researchers lead team in discovery involving devastating freshwater fish parasite, Ich
6. Discovery makes brain tumor cells more responsive to radiation
7. Discovery of the Jekyll-and-Hyde factors in coral bleaching
8. Rocket science leads to new whale discovery
9. A year after discovery, Congos mother lode of gorillas remains vulnerable
10. Cancer metabolism discovery uncovers new role of IDH1 gene mutation in brain cancer
11. Its a gas: New discovery may lead to heartier, high-yielding plants
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/13/2015)... April 13, 2015  higi, a leading cloud-based consumer ... more fully engage with their communities around health and ... protected and secure API.  ... most accessible, affordable, and convenient vehicle to receive validated ... The API will allow higi,s trusted ...
(Date:4/6/2015)... 6, 2015 NXT-ID, Inc. (NASDAQ: NXTD ... company focused on the growing mobile commerce market, ... 62/143028 for MINIATURE, MULTI-PURPOSE ANTENNA METHOD AND ... NXT-ID introduces a new revolutionary method and ... the use of miniature antenna modules for multiple ...
(Date:4/2/2015)... Fingerprint Cards (FPC) has received ... the distributor World Peace Industrial Group (WPI), part of ... the major part of the shipments will take place ... smartphone manufacturers in China . The ... communicated revenue guidance of + 1 000 MSEK for 2015.  ...
Breaking Biology News(10 mins):higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 2higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 3NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 2NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 3NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 4Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 110 Million 2
... in French . New research reveals ... investors trading stocks are faced with the same fundamental challenge ... and benefits. A neuroeconomics study from the Montreal Neurological Institute ... brain employs two separate regions and two distinct processes in ...
... have developed a new concept for rechargeable batteries. Based ... anions between the electrodes -- it promises to enhance ... factors. Operational safety is also increased, as it can ... for the first time in the Journal of ...
... the October 20th edition of the journal Cell Host ... of the Departments of Medicine and Microbiology at NYU Langone ... University, present a model for understanding how cancer evolves in ... our body, the microbiome. The authors suggest that ...
Cached Biology News:What you want vs. how you get it 2What you want vs. how you get it 3What you want vs. how you get it 4Fluoride shuttle increases storage capacity 2
(Date:5/6/2015)... , May 6, 2015  Endo International plc (NASDAQ: ... De Silva , President and CEO, will present a corporate ... New York City on Wednesday, May 20, 2015 ... and audio archive for the event will be available on ... Relations, and then the link to the event. Participants should ...
(Date:5/6/2015)... 6, 2015  Oxis Biotech, Inc. (OXIS), a wholly ... announced today that Cassian Yee , M.D., Professor, ... at the University of Texas MD Anderson Cancer Center ... Professor, Department of Immunology, Division of Cancer Medicine, and ... Research at the University of Texas MD Anderson Cancer ...
(Date:5/6/2015)... The Remedy Group , the premier ... specialty pharmacy industry, will be exhibiting, presenting, and is ... Summit. The Summit will be held May 4-8, 2015 ... the largest annual gathering for the specialty pharmacy industry. ... providers, pharma/biotech manufacturers, and payers, to learn more about ...
(Date:5/5/2015)...  23andMe, Inc., the leading personal genetics company, today ... in collaboration with Pfizer Inc. The companies aim ... commonly known as lupus, into the study to help ... also in collaboration with the Lupus Research Institute, and ... Approximately 1.5 million people in the U.S. suffer ...
Breaking Biology Technology:Oxis Biotech Appoints Cassian Yee, M.D. To Its Scientific Advisory Board 2Oxis Biotech Appoints Cassian Yee, M.D. To Its Scientific Advisory Board 3The Remedy Group presenting at the 2015 Armada Specialty Pharmacy Summit: The Pitfalls to Growth and Maintaining the Patient Experience 223andMe Launches the Lupus Research Study in Collaboration with Pfizer Inc. 223andMe Launches the Lupus Research Study in Collaboration with Pfizer Inc. 3
... Application Breadth of Market-Leading ... IVIS Instrument Family - ... HOPKINTON, Mass., Sept. 9 Caliper Life,Sciences, Inc. (Nasdaq: CALP ... sciences research, today introduced the IVIS(R),Kinetic preclinical in vivo imaging system. The ...
... InNexus,Biotechnology Inc., (TSX: IXS.V, OTC Bulletin Board: IXSBF, ... next,generation of monoclonal antibodies based on its Dynamic ... Board of Directors., Mr. Warden was a ... his 23 years of practice, he has represented ...
... workers exposed to flammable vapors or dusts be protected by UL ... now has a significant offering of these lights available for oil ... ... Dallas, TX (PRWEB) September 9, 2008 -- OSHA requirements mandate that ...
Cached Biology Technology:Caliper Launches Small Animal Molecular Imaging System Enabling Real-Time Video Observation 2Caliper Launches Small Animal Molecular Imaging System Enabling Real-Time Video Observation 3InNexus Biotechnology Strengthens Patent Team With New Leadership 2Explosion Proof Fluorescent Lights Keep Paint Spray Booths and Oil Rig Workers Safe 2
...
... PP2A1, purified Formulation: 50mM Tris-HCl, ... Brij-35, 0.2mM PMSF, 1mM benzamidine, ... Properites: PP2A1 (Protein Phosphatase 2A1) ... ammonium sulfate precipitation, QSepharose,amino-hexyl agarose, ...
Borosilicate Glass. Certified for use with the Beacon 2000 Systems, 1,000 tubes/case...
...
Biology Products: