Navigation Links
Discovery about DNA repair could lead to improved cancer treatments
Date:9/10/2013

Medical researchers at the University of Alberta have made a basic science discovery that advances the understanding of how DNA repairs itself. When DNA becomes too damaged it ultimately leads to cancer.

Faculty of Medicine & Dentistry researcher Mark Glover and his colleagues published their findings in the peer-reviewed journal, Structure (Cell Press), earlier this summer. For years, scientists thought two key proteins involved in DNA repair operated in exactly the same way. Glover's team discovered how the proteins operate and communicate is vastly different information that could lead to improved cancer treatments.

Glover explains that a protein known as BRCA1 acts like a hallway monitor constantly scanning DNA for damage. At the first sign of problems, this protein figures out what kind of help is needed, and "radios" in a cleanup crew of other proteins.

A second protein, known as TopBP1, ensures that DNA can copy itself when needed. When this process stalls due to DNA damage, this protein also calls in a cleanup crew. But Glover likens its method of communication to tweets, rather than radio.

"The two proteins may be related and look very similar, but their roles and the way they communicate are in fact very different, which was surprising to us," Glover says. "Each protein plays a role in recognizing damaged regions of DNA, but the problem they each solve is different.

"The question now is how can we use this information to try to improve cancer therapies? Could we temporarily knock out cancer DNA's ability to repair itself from radiation damage? Could we administer radiation at a point that prevents cancer DNA from copying itself? Could we inhibit the activity of proteins that are normally trying to run around and fix the damage?

"Maybe some of these ideas could ultimately translate into less radiation or chemotherapy needed for patients, if the treatment can be more targeted," says Glover, wh
'/>"/>

Contact: Raquel Maurier
rmaurier@ualberta.ca
780-492-5986
University of Alberta Faculty of Medicine & Dentistry
Source:Eurekalert

Page: 1 2

Related biology news :

1. Discovery helps to unlock brains speech-learning mechanism
2. University of Hawaii Cancer Center researchers discovery
3. 4 projects awarded Discovery Transformation Grant funding by Minnesota Partnership
4. NOAA reports discovery of table coral, Acropora cytherea, off Oahu
5. UK researcher earns 2013 Discovery Award
6. Molecular discovery puts cancer treatment in a new perspective
7. Discovery of the Plastisphere -- a new marine ecological community
8. Unexpected discovery of the ways cells move could boost understanding of complex diseases
9. Discovery of how a gene that regulates factors involved in bacteria pathogenicity acts
10. Discovery of new material state counterintuitive to laws of physics
11. Discovery of the gene responsible for multiple intestinal atresia in newborns
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... University is paving the way for a breakthrough ... military troops exposed to poisonous chemicalsparticularly those in ... in the current issue of the journal ... which are compounds commonly used in pesticides and ... NYU School of Engineering Associate Professor of Chemical ...
(Date:7/30/2014)... Carroll,s Through the Looking Glass, collaborators from the ... improved a 35-year-old ecology model to better understand ... years. , The new model, called a mean ... Effect," an evolutionary hypothesis introduced by Lee Van ... must constantly increase their fitness (or ability to ...
(Date:7/30/2014)... American Chemical Society (ACS) announced today that David L. ... ACS Biomaterials Science & Engineering as editor-in-chief. With ... the new journal will feature high-quality research in the ... or naturally derived materials that interact with living or ... it reflects the tremendous growth in the field of ...
Breaking Biology News(10 mins):Engineering a protein to prevent brain damage from toxic agents 2Classic Lewis Carroll character inspires new ecological model 2Classic Lewis Carroll character inspires new ecological model 3ACS Biomaterials Science & Engineering: Brand-new journal launches in 2015, names editor 2
... interdisciplinary perspective. Presenters at the National Academy of Sciences, ... ways to identify, encourage, and support advances in climate ... other fields. In addition, U.S. Secretary ... Sackler Lecture beginning at 6 p.m. on March 31 ...
... Providing further understanding of the link between low birth ... deprived newborns are "programmed" to eat more because they ... that controls food intake, according to an article published ... The study by a team of researchers at Los ...
... of people commit suicide worldwide each year, researchers and ... person,s likelihood of thinking about or trying to commit ... Hospital del Mar Research Institute (IMIM) has participated, has ... suicides. "It is of key importance to identify suicidal ...
Cached Biology News:Study provides explanation for connection between low birth weight and obesity later in life 2First international index developed to predict suicidal behavior 2
(Date:7/31/2014)... NY (PRWEB) July 31, 2014 North Shore ... York City, partnered with GI Energy, one of the nation’s ... a $13 million upgrade of its 43-year-old CHP system. The ... and in an effort to extend the life of the ... generators and associated electrical and heat recovery equipment, while maintaining ...
(Date:7/31/2014)... CollabRx, Inc. (NASDAQ: CLRX), a leading provider ... today announced that it will hold an investor conference ... financial results for the first quarter of fiscal 2015 ... the current fiscal year. , The dial-in number for ... 2014, at 5 p.m. EDT (2 p.m. PDT) is ...
(Date:7/31/2014)... SAN DIEGO and SHENZHEN, China ... Genomics announced today the purchase of an ... genomics organization. BGI selected BioNano,s platform to enable comprehensive ... vastly improved assemblies for various organisms of interest, including ... BGI will partner together to develop new methods for ...
(Date:7/31/2014)... The global market for molecular diagnostics is expected to ... new study by Grand View Research, Inc. Growing demand ... of advanced cancer diagnostic technologies are expected to be ... years. Moreover, the growing global base of geriatric population ... triggering lifestyle habits such as smoking and excessive alcohol ...
Breaking Biology Technology:North Shore Towers Partners with GI Energy to Install Turnkey Natural Gas-Fired Combined Heat and Power Plant 2CollabRx, Inc. Schedules First Quarter Fiscal Year 2015 Financial Conference Call and Business Update 2BioNano Genomics Announces the Purchase of the Irys System by BGI 2BioNano Genomics Announces the Purchase of the Irys System by BGI 3BioNano Genomics Announces the Purchase of the Irys System by BGI 4Molecular Diagnostics Market - Global Industry Size, Share, Trends, Analysis, Players, Opportunity, Outlook and Forecast From 2014 to 2020 2Molecular Diagnostics Market - Global Industry Size, Share, Trends, Analysis, Players, Opportunity, Outlook and Forecast From 2014 to 2020 3Molecular Diagnostics Market - Global Industry Size, Share, Trends, Analysis, Players, Opportunity, Outlook and Forecast From 2014 to 2020 4Molecular Diagnostics Market - Global Industry Size, Share, Trends, Analysis, Players, Opportunity, Outlook and Forecast From 2014 to 2020 5
... April 1, 2008 Cardium Therapeutics,(Amex: ... Therapies announced today that,InnerCool has entered into ... (Euromed), a leading distributor of cardiology,medical products. ... will have,exclusive marketing, sales and distribution rights ...
... April 1, 2008 Piedmont Heart Institute (PHI),expands ... cardiovascular,physician practice, Cardiology of Georgia, P.C. (COG), through ... 2008. With eight,locations including Buckhead, Canton, Fayetteville and ... under the Piedmont Heart Institute and an,important addition ...
... 1, 2008 ,Neurobiological Technologies, Inc. (NTI(R)) (Nasdaq: NTII ... Loar has been appointed Chief,Financial Officer. Mr. Loar will ... joins the company from Osteologix, where he has served,as ... proven track record as a chief financial officer, and ...
Cached Biology Technology:Cardium's InnerCool Therapies Unit Announces European Commercialization Agreement for Portfolio of Temperature Modulation Systems 2Cardium's InnerCool Therapies Unit Announces European Commercialization Agreement for Portfolio of Temperature Modulation Systems 3Cardium's InnerCool Therapies Unit Announces European Commercialization Agreement for Portfolio of Temperature Modulation Systems 4Cardium's InnerCool Therapies Unit Announces European Commercialization Agreement for Portfolio of Temperature Modulation Systems 5Cardium's InnerCool Therapies Unit Announces European Commercialization Agreement for Portfolio of Temperature Modulation Systems 6Cardium's InnerCool Therapies Unit Announces European Commercialization Agreement for Portfolio of Temperature Modulation Systems 7Cardium's InnerCool Therapies Unit Announces European Commercialization Agreement for Portfolio of Temperature Modulation Systems 8Cardium's InnerCool Therapies Unit Announces European Commercialization Agreement for Portfolio of Temperature Modulation Systems 9Piedmont Heart Institute Welcomes Cardiology of Georgia 2Piedmont Heart Institute Welcomes Cardiology of Georgia 3Piedmont Heart Institute Welcomes Cardiology of Georgia 4Neurobiological Technologies Appoints Matthew M. Loar as Chief Financial Officer 2Neurobiological Technologies Appoints Matthew M. Loar as Chief Financial Officer 3
UltraPure DNase/RNase-Free Distilled Water is designed for use in all molecular biology applications. It is 0.1-m membrane-filtered and tested for DNase and RNase activity....
...
Water Distilled (Gibco™) is membrane filtered and endotoxin screened....
The S. cerevisiae Hansen strains are the parental yeast strains from which the deletions were derived....
Biology Products: