Navigation Links
Discovered the existence of neutrophils in the spleen
Date:12/25/2011

This release is available in Spanish.

Barcelona, 23rd of December 2011.- For the first time, it has been discovered that neutrophils exist in the spleen without there being an infection. This important finding made by the research group on the Biology of B Cells of IMIM (Hospital del Mar Research Institute) in collaboration with researchers from Mount Sinai in New York, has also made it possible to determine that these neutrophils have an immunoregulating role.

Neutrophils are the so-called cleaning cells, since they are the first cells to migrate to a place with an infection and inflammation to destroy the pathogens. Until now, scientific literature had considered neutrophils essentially as lowly qualified soldiers that simply limited the expansion of an infection, as a first action to pave the way for other cells of the immune system in charge of eradicating the infection permanently.

"This study has revealed that neutrophils are found in the spleen without there being an infection, contributing totally new knowledge in the field of biology" explains Andrea Cerutti, the coordinator of the research group on the Biology of B Cells of IMIM, a professor at ICREA and the last signatory of the article.

Researchers noticed that the existence of neutrophils in the spleen started when the fetus is developing, even when there is no infectious process involved; this was not known in scientific literature. The study was expanded to people of different ages and other mammals. Detecting the presence of neutrophils in the spleen suggested that these played a different role in the spleen to the one usually given to them.

The neutrophils in the spleen are located around B lymphocytes to help their activation and offer a first rapid response when there are pathogens. "through several different experimental approaches we have proven that neutrophils in the spleen acquire the ability to interact with B cells or B lymphocytes, inducing the production of antibodies, a role that lymphocytes circulating in blood are not able to do" states Irene Puga, researcher of the IMIM and a signatory of this article.

This finding improves the understanding of the mechanisms with which our immune system protects us against an infection, an essential requirement to better control all pathologies linked to it. Also, when faced with certain diseases, such as neutropenia (or a numeric deficiency of neutrophils), it will become necessary to study not only the deficiency of neturophils, but also how this affects the production of antibodies.

This work opens the door to therapies which are geared at, and more affective against, different pathogens, for example, to develop vaccines to increase the capacity of neutrophils in the spleen so as to have an incidence on the production of antibodies by type B lymphocytes.


'/>"/>

Contact: Marta Calsina
mcalsina@imim.es
34-933-160-680
IMIM (Hospital del Mar Research Institute)
Source:Eurekalert  

Related biology news :

1. Plant-eating dinosaur discovered in Antarctica
2. Worlds smallest frogs discovered in New Guinea
3. Early lineage of Larkspur and Monkshood plants rediscovered in Southern Europe
4. New tick-borne disease discovered in Gothenburg
5. Unknown species and larval stages of extremely long-legged beetles discovered by DNA test
6. New drug target for Alzheimers, stroke is discovered by University at Buffalo scientists
7. Giant kraken lair discovered
8. Factor in keeping good order of genes discovered
9. New inherited neurometabolic disorder discovered
10. Control gene for developmental timing discovered
11. New type of spinal cord stem cell discovered
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Discovered the existence of neutrophils in the spleen
(Date:3/2/2017)... March 2, 2017 Summary This report ... and its partnering interests and activities since 2010. ... Read the full ... Alliance since 2010 report provides an in-depth insight into the ... companies. On demand company reports are prepared upon ...
(Date:2/28/2017)... , Feb. 28, 2017   Acuant , ... software globally, announces significant enhancements to new and core ... 2016. New products include mobile and desktop Acuant FRM ... TM - a real time manual review of ... idScan® technology provides the fastest and most accurate capture ...
(Date:2/24/2017)... , Feb. 24, 2017  EyeLock LLC, a leader ... its elite iris biometric solution on the latest ... LTE at Mobile World Congress 2017 (February ... Booth in Hall 3, Stand 3E10. ... Qualcomm Haven™ security platform—a combination of hardware, ...
Breaking Biology News(10 mins):
(Date:3/22/2017)... San Diego, Calif. (PRWEB) , ... March 21, ... ... Frame on Kickstarter , more than tripling its goal and raising over ... and low-maintenance vertical garden that grows nutritious veggies & herbs fast, easy, and ...
(Date:3/22/2017)... ... March 21, 2017 , ... ... unveiled its innovative Quantum peristaltic pump with patented ReNu single-use (SU) cartridge ... new standard for high-pressure feed pumps in SU tangential flow filtration (TFF), ...
(Date:3/22/2017)... (PRWEB) , ... March 22, 2017 , ... The Society ... research agencies as outlined in the Administration’s recently published fiscal year 2018 budget request. ... National Institutes of Health (NIH) by $5.8 billion or roughly 20% of its total ...
(Date:3/22/2017)... Israel , March 22, 2017 /PRNewswire/ ... of adult stem cell technologies for neurodegenerative diseases, announced ... will provide an update on new developments and a ... Neuroscience Biopartnering and Investment Forum, being held on March ... Sciences. Neuroscience ...
Breaking Biology Technology: