Navigation Links
Discovered a new checkpoint of cell cycle control through joint action of 2 proteins
Date:5/22/2012

Alterations in the formation of ribosomes (the elements of the cell where proteins are made) cause the induction of p53 protein and cell cycle disruption. This process is crucial to understand fundamental biological processes and the emergence of various diseases. Now, scientists at the Bellvitge Biomedical Research Institute (IDIBELL) have found that this response is achieved independently, depending on which subunit of the ribosome (40S and 60S) is impaired, by the joint action of two proteins of the ribosome. The research results are published in the latest issue of the journal Genes and Development.

The p53 protein, produced by the gene of the same name, is a tumour suppressor in humans and other mammals. Half of human tumours have mutations in the p53 gene and alterations of regulators of this gene are present in many other cancers. However, p53 is not only a tumour suppressor but is involved in other cellular processes such as longevity, mitochondrial oxidation and glucose metabolism. Activation of p53 protein due to malfunctions in the formation of ribosomes is associated with several rare diseases that are linked with mutations in components of the cell nucleus.

The study by IDIBELL researchers shows that ribosomal proteins RPL11 and RPL5 cooperate to suppress Hdm2, another protein that regulates the degradation of p53. This causes increased levels of p53 and cell cycle arrest. These results are contrary to previous dogma, claiming that other ribosome proteins could elicit a similar response to RPL11 and RPL5.

The coordinator of the study, George Thomas, director of the research group of Metabolic Diseases and Cancer at IDIBELL explains that the knowledge of this mechanism "may have implications in understanding fundamental processes such as longevity, metabolic diseases or cancer and can provide a basis for developing new drugs."


'/>"/>
Contact: Jordi Morat
comunicacio@idibell.cat
IDIBELL-Bellvitge Biomedical Research Institute
Source:Eurekalert

Page: 1

Related biology news :

1. New key mechanism in cell division discovered
2. Low-cost nanosheet catalyst discovered to split hydrogen from water
3. Global warming refuge discovered near at-risk Pacific island nation of Kiribati
4. Key proteins newly discovered form and function may provide novel cancer treatment target
5. 24 new species of lizards discovered on Caribbean islands are close to extinction
6. New form of intellectual disability discovered
7. Scientists have discovered genes that increase the risk of osteoporosis and fractures
8. Housekeeping mechanism for brain stem cells discovered
9. New genetic mechanism of immune deficiency discovered
10. New immune defense enzyme discovered
11. Newly discovered foot points to a new kid on the hominin block
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/15/2017)... 15 2017   ivWatch LLC , a medical device company ... today announced receipt of its ISO 13485 Certification, the global standard ... Organization for Standardization (ISO®). ... Model 400 Continuous Monitoring device for the early detection of IV ... "This is an important milestone for ...
(Date:5/23/2017)... , May 23, 2017  Hunova, the first robotic gym for the ... been officially launched in Genoa, Italy . The first ... and the USA . The technology was developed ... market by the IIT spin-off Movendo Technology thanks to a 10 million ... News Release, please click: ...
(Date:4/19/2017)... 2017 The global military biometrics ... marked by the presence of several large global players. ... five major players - 3M Cogent, NEC Corporation, M2SYS ... nearly 61% of the global military biometric market in ... global military biometrics market boast global presence, which has ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... 2017 SomaGenics announced the receipt of a ... RealSeq®-SC (Single Cell), expected to be the first commercially ... microRNAs) from single cells using NGS methods. The NIH,s ... accelerate development of approaches to analyze the heterogeneity of ... techniques for measuring levels of mRNAs in individual cells ...
(Date:10/9/2017)... 9, 2017  BioTech Holdings announced today identification ... its ProCell stem cell therapy prevents limb loss ... Company, demonstrated that treatment with ProCell resulted in ... as compared to standard bone marrow stem cell ... in reduction of therapeutic effect.  ...
(Date:10/9/2017)... ... October 09, 2017 , ... The Giving Tree Wellness Center ... the needs of consumers who are incorporating medical marijuana into their wellness and ... , As operators of two successful Valley dispensaries, The Giving Tree’s two founders, ...
(Date:10/7/2017)... ... October 06, 2017 , ... ... ProxiMeta™ Hi-C metagenome deconvolution product, featuring the first commercially available Hi-C kit. ... to perform Hi-C metagenome deconvolution using their own facilities, supplementing the company’s ...
Breaking Biology Technology: