Navigation Links
Disarming disease-causing bacteria
Date:4/5/2012

Scientists could produce new antibacterial treatments by disarming the molecular pumps bacteria use to bring disease causing molecules in contact with animals and humans.

Research published today in Nature Structure and Molecular Biology showed a protein complex called the Translocation and Assembly Module (TAM), forms a type of molecular pump, allowing bacteria to shuttle key disease causing molecules from inside the bacterial cell where they are made, to the outside surface, priming the bacteria to infect other organisms.

The international research collaboration, led by Monash University, paves the way for future studies to design new drugs that inhibit this process.

The TAM was discovered in many disease-causing bacteria, from micro-organisms that cause whooping cough and meningitis, to hospital-acquired bacteria that are developing resistance to current antibiotics.

The Monash team, led by Professor Trevor Lithgow from the Department of Biochemistry and Molecular Biology, showed the TAM was made of two protein parts, TamA and TamB, which function together to form a machine of molecular scale.

Lead author and PhD student Joel Selkrig said the team, with colleagues at the University of Melbourne, compared mutant strains of bacteria engineered to have no TAM, to normal virulent bacteria.

"We noticed that proteins important for disease were missing in the outer membrane of the mutant bacteria," Mr Selkrig said.

"The missing proteins help the bacteria to adhere to our bodies and perform disease-related functions."

Mr Selkrig said the next step for the group was to dissect the molecular mechanism of how the TAM complex functions and, in collaboration with researchers at the Monash Institute of Pharmaceutical Sciences, design an antibiotic that inhibits the TAM in bacteria.

"The TAM is a good antibacterial target because a drug designed to inhibit TAM function would not kill bacteria, it would simply deprive them of their molecular weaponry, and in doing so, disable the disease process," Mr Selkrig said.

"By allowing bacteria to stay alive after antibiotic treatment, we believe we can also prevent the emergence of antibiotic resistance, which is fast-becoming a major problem worldwide."

Professor Lithgow led a team of seven Monash researchers, and scientists from the University of Melbourne, University of Queensland, the University of Glasgow and University of Birmingham.


'/>"/>

Contact: Emily Walker
emily.walker@monash.edu
61-399-034-844
Monash University
Source:Eurekalert

Related biology news :

1. Disarming specialized stem cells might combat deadly ovarian cancer
2. Disease-causing strains of Fusarium prevalent in plumbing drains
3. UC Davis researchers find disease-causing fat cells in those with metabolic syndrome
4. New research shows how disease-causing parasite gets around human innate immunity
5. Research targets basic metabolism of disease-causing fungi, bacteria
6. New plastic-like materials may say shhhh to hush disease-causing microbes
7. Scientists gain new understanding of disease-causing bacteria
8. NJIT professor finds engineering technique to identify disease-causing genes
9. Bacterial shock to recapture essential phosphate
10. From scourge to saint: E. coli bacteria becomes a factory - to make cheaper, faster pharmaceuticals
11. Team discovers how bacteria resist a Trojan horse antibiotic
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/13/2017)... , Feb. 13, 2017 Former 9/11 ... Senate Judiciary Committee, Janice Kephart of Identity ... President Donald Trump,s "Executive Order: Protecting the ... (Jan. 27, 2017):  "As President Trump,s ,Travel ... Circuit has now essentially banned the travel ban, it ...
(Date:2/8/2017)... NEW YORK , Feb. 8, 2017 /PRNewswire/ ... an individual,s voice to match it against a ... voice such as pitch, cadence, and tone are ... systems require minimal hardware installation, as most PCs ... remotely for different transactions. Voice recognition biometrics are ...
(Date:2/8/2017)... NEW YORK , Feb. 7, 2017 /PRNewswire/ ... point. Driven largely by the confluence of organizations, ... users, distaste for knowledge-based systems (password and challenge ... consumer, industrial, and government systems. The market is ... been a demarcation between consumer and enterprise uses ...
Breaking Biology News(10 mins):
(Date:2/22/2017)... -- Dublin - Research and ... Protection (Bio-Pesticide) Market-By Type, By Application, By End User, By Region, ... ... Crop Protection Market is forecasted to grow at a CAGR of ... or biological crop protection market is driven by the surging demand ...
(Date:2/22/2017)... DIEGO , Feb. 22, 2017  Creative ... expansion of its translational research program using its ... of laboratory facilities in San Diego.  The Company ... BioLabs facility, a biotechnology incubator sponsored by the ... In November 2016, the Company obtained an ...
(Date:2/21/2017)... ... February 21, 2017 , ... ... System , a fully automated benchtop system for collecting intact circulating tumor cells ... launched at the Molecular Medicine Tri Conference (Tri-Con) Annual Meeting 2017 (February 19–24 ...
(Date:2/21/2017)... ... February 21, 2017 , ... VetStem Biopharma, Inc ... headquarters laboratory in Poway, California. Based upon 12 years of knowledge gained ... and consultants, VetStem constructed and validated a state-of-the-art GMP stem cell manufacturing plant. ...
Breaking Biology Technology: