Navigation Links
Disarming disease-causing bacteria
Date:4/5/2012

Scientists could produce new antibacterial treatments by disarming the molecular pumps bacteria use to bring disease causing molecules in contact with animals and humans.

Research published today in Nature Structure and Molecular Biology showed a protein complex called the Translocation and Assembly Module (TAM), forms a type of molecular pump, allowing bacteria to shuttle key disease causing molecules from inside the bacterial cell where they are made, to the outside surface, priming the bacteria to infect other organisms.

The international research collaboration, led by Monash University, paves the way for future studies to design new drugs that inhibit this process.

The TAM was discovered in many disease-causing bacteria, from micro-organisms that cause whooping cough and meningitis, to hospital-acquired bacteria that are developing resistance to current antibiotics.

The Monash team, led by Professor Trevor Lithgow from the Department of Biochemistry and Molecular Biology, showed the TAM was made of two protein parts, TamA and TamB, which function together to form a machine of molecular scale.

Lead author and PhD student Joel Selkrig said the team, with colleagues at the University of Melbourne, compared mutant strains of bacteria engineered to have no TAM, to normal virulent bacteria.

"We noticed that proteins important for disease were missing in the outer membrane of the mutant bacteria," Mr Selkrig said.

"The missing proteins help the bacteria to adhere to our bodies and perform disease-related functions."

Mr Selkrig said the next step for the group was to dissect the molecular mechanism of how the TAM complex functions and, in collaboration with researchers at the Monash Institute of Pharmaceutical Sciences, design an antibiotic that inhibits the TAM in bacteria.

"The TAM is a good antibacterial target because a drug designed to inhibit TAM function would not kill bacteria, it would simply deprive them of their molecular weaponry, and in doing so, disable the disease process," Mr Selkrig said.

"By allowing bacteria to stay alive after antibiotic treatment, we believe we can also prevent the emergence of antibiotic resistance, which is fast-becoming a major problem worldwide."

Professor Lithgow led a team of seven Monash researchers, and scientists from the University of Melbourne, University of Queensland, the University of Glasgow and University of Birmingham.


'/>"/>

Contact: Emily Walker
emily.walker@monash.edu
61-399-034-844
Monash University
Source:Eurekalert

Related biology news :

1. Disarming specialized stem cells might combat deadly ovarian cancer
2. Disease-causing strains of Fusarium prevalent in plumbing drains
3. UC Davis researchers find disease-causing fat cells in those with metabolic syndrome
4. New research shows how disease-causing parasite gets around human innate immunity
5. Research targets basic metabolism of disease-causing fungi, bacteria
6. New plastic-like materials may say shhhh to hush disease-causing microbes
7. Scientists gain new understanding of disease-causing bacteria
8. NJIT professor finds engineering technique to identify disease-causing genes
9. Bacterial shock to recapture essential phosphate
10. From scourge to saint: E. coli bacteria becomes a factory - to make cheaper, faster pharmaceuticals
11. Team discovers how bacteria resist a Trojan horse antibiotic
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/28/2017)... -- News solutions for biometrics, bag drop and New ... At ... 16 March, Materna will present its complete end-to-end passenger journey, ... a real benefit for passengers. To accelerate the whole passenger ... point solutions to take passengers through the complete integrated process ...
(Date:2/26/2017)... 2017  Securus Technologies, a leading provider of ... safety, investigation, corrections and monitoring, announces the appointment ... "Too often, too many offenders return to ... are trying to tackle this ongoing problem and ... family members. While significant steps are underway, Securus continues ...
(Date:2/21/2017)... and PORTLAND, Ore. , ... and the Avamere Family of Companies (Avamere Health Services, ... announced a six-month research study that will apply the ... eldercare at senior living and health centers. By analyzing ... hopes to gain insights into physical and environmental conditions, ...
Breaking Biology News(10 mins):
(Date:3/23/2017)... 23, 2017  SeraCare Life Sciences, Inc., a ... vitro diagnostics manufacturers and clinical laboratories, is ... multiplexed Inherited Cancer reference material ... next-generation sequencing (NGS). The Seraseqâ„¢ Inherited Cancer DNA ... from industry experts to validate the ability ...
(Date:3/23/2017)... -- BioPharmX Corporation (NYSE MKT: BPMX), a specialty pharmaceutical ... reported financial results for the quarter and year ... update on the company,s clinical development efforts and ... pleased to report that last year was a ... Krammer. "We achieved key clinical milestones and attracted ...
(Date:3/23/2017)... 23, 2017 Kineta, Inc., a biotechnology ... therapies in immuno-oncology, today announced the discovery and ... compounds that activate interferon response factor 3 (IRF3) ... immune-mediated tumor regression in a murine colon carcinoma ... demonstrated complete tumor regression to initial drug treatment ...
(Date:3/23/2017)... According to a report by Transparency Market Research (TMR), ... the presence of a large pool of participants; however, only a ... Sigma-Aldrich, compete with each other in this market. With Proliant being ... of this market in 2016.  ... As of now, a large number of vendors are ...
Breaking Biology Technology: