Navigation Links
Disappearance of genetic material allows tumor cells to grow
Date:8/4/2011

Malignant Szary syndrome is characterized by the reproduction of a special type of white blood cells in the skin of male and female patients. In contrast to most other skin lymphomas, patients with Szary syndrome manifest not only skin contamination but also contamination of blood and lymph nodes by degenerate T cells even at the onset of the disease. The researchers investigated highly purified tumor cells from patients with Szary syndrome using modern, high-resolution genetic procedures (the so-called array comparative genomic hybridization technique) for hitherto unknown genetic changes. In doing so they identified areas in the genotype of these tumor cells that have become lost in many of the patients examined. A detailed analysis of these areas showed that one of the most frequently affected genes codes for a so-called transcription factor. Transcription factors have key functions in the regulation of cellular gene activity.

"The partial loss of the gene for transcription factor E2A appears to play an essential role in this context because the gene is normally of great importance for natural lymphocyte development," explains explained Chalid Assaf from the Charit Klinik fr Dermatologie, Venerologie und Allergologie. In mice a loss of this gene leads to the genesis of aggressive T cell lymphomas. However, a gene loss in one of the various human lymphoma classes had so far remained elusive.

The researchers also identified several E2A-regulated genes and signal paths in tumor cells, the mere deregulation of each of which is sufficient to enable a tumor to develop. "Loss of E2A in Szary syndrome is of crucial importance for the aggressive behavior of tumor cells because it contributes to more rapid, uncontrolled growth of cells," emphasized Stephan Mathas, a scientist at the Charit Klinik fr Hmatologie und Onkologie and at MDC. Consequently, it was directly proven for the first time that E2A in humans has the function of a tumor suppressor.

The researchers hope that these findings will lead to the development of new, more effective treatment concepts for patients with Szary syndrome.


'/>"/>

Contact: Barbara Bachtler
bachtler@mdc-berlin.de
49-309-406-3896
Helmholtz Association of German Research Centres
Source:Eurekalert

Related biology news :

1. Mallory and Irvine: Did extreme weather cause their disappearance?
2. Rare genetic disorder gives clues to autism, epilepsy, mental retardation
3. Genetic Engineering & Biotechnology News reports on growing role of molecular diagnostics
4. Study finds genetic variant plays role in cleft lip
5. Genetic finding implicates innate immune system in major cause of blindness
6. American College of Medical Genetics receives $13.5M NIH contract
7. Clue to genetic cause of fatal birth defect
8. Can genetic information be controlled by light?
9. The American Society of Human Genetics hosts 58th Annual Meeting in Philadelphia
10. Modern genetics vs. ancient frog-killing fungus
11. Genetic based human diseases are an ancient evolutionary legacy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/11/2016)... Synaptics Incorporated (NASDAQ: SYNA ), the ... its ClearPad ® TouchView ™ 4300 touch ... categories in the 8 th Annual Mobile Excellence ... The Synaptics ® TDDI solution enables faster time-to-market, ... devices, brighter displays and borderless designs. ...
(Date:1/8/2016)... Kingdom , Jan. 8, 2016   Bruin Biometrics, ... today announced the closing of a $9 million financing. The ... the financing will be used to accelerate the commercialization of ... early-stage pressure ulcers. United Kingdom ... Mark approval. The device,s introduction has been met with enthusiasm ...
(Date:1/7/2016)... , Jan. 7, 2016 This BCC ... markets for biometric technologies and devices, identifying newer markets ... for various types of biometric devices. Includes forecast from ... Identify newer markets and explore the expansion of ... devices. Examine each type of biometric technology, determine its ...
Breaking Biology News(10 mins):
(Date:2/8/2016)... 2016 /PRNewswire/ - BIOREM Inc. (TSXV: BRM) ("Biorem" or "the ... for clean technology companies in the TSX Venture 50 TM ... listed on the TSX Venture Exchange, in each of five ... technology & life sciences, diversified industries and technology – ... return on investment, market cap growth, trading volume and analyst ...
(Date:2/8/2016)... Feb. 8, 2016  CytRx Corporation (NASDAQ: ... specializing in oncology, today announced that it has ... with Hercules Technology Growth Capital, Inc. and Hercules ... in financing. --> ... million of financing under the loan and security ...
(Date:2/8/2016)... , Feb. 8, 2016 Novan, Inc. today announced that ... the Board of Directors of Novan. In addition, Robert Keegan ... North Carolina . --> ... announced that it received a total of $32.8 million of net ... its private investor network originating throughout the Research Triangle area of ...
(Date:2/8/2016)... , Feb. 8, 2016  BioElectronics Corporation (OTC ... devices, announced today that it is responding to ... from the Securities and Exchange Commission posted on ... , Chairman of the Board of BioElectronics Corporation ... Business Administration at The Fuqua School of Business, ...
Breaking Biology Technology: