Navigation Links
Disabling mouse enzyme increases fertility
Date:5/16/2008

St. Louis, May 16, 2008 Changing the sugars attached to a hormone produced in the pituitary gland increased fertility levels in mice nearly 50 percent, a research group at Washington University School of Medicine in St. Louis has found. The change appears to alter a reproductive "thermostat," unveiling part of an intricate regulatory system that may one day be used to enhance human fertility.

"To adjust for the right amount of key reproductive hormones such as estrogen and testosterone, we may someday alter the sugars that are added to this hormone or others like it," says the group's leader, Jacques Baenziger, M.D., Ph.D., professor of pathology and immunology and of cell biology and physiology.

The report appeared recently in The Journal of Clinical Investigation.

Sugars are the most common addition to hormones and other proteins after they have been assembled from instructions in DNA. Nearly all proteins in the blood and on the surface of cells have sugars attached. Scientists believe sugar attachments modify and adapt proteins, enabling them to fill more than one job or changing the way they do their jobs in different contexts. But direct demonstration of such changes has been challenging.

Baenziger found a unique set of sugars consistently added to luteinizing hormone, which is part of a feedback loop between the pituitary, the reproductive organs and the liver. The loop cycles up and down over time, producing periodic peaks in other reproductive hormones and triggering regular events such as the ovaries' release of eggs.

For their study, Baenziger's laboratory genetically disabled one of the enzymes that attaches sugars to luteinizing hormone in mice. This enzyme isn't the only one to add sugars to the hormone, so the alteration changes the mix of sugars rather than eliminating them completely.

Initially, we didnt seem to see much of a difference in the animals, Baenziger says. But then someone cam
'/>"/>

Contact: Michael Purdy
purdym@wustl.edu
314-286-0122
Washington University School of Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. Study reveals 2 genes linked to disabling arthritis
2. Mouse can do without mans most treasured genes
3. Mouse study: When it comes to living longer, its better to go hungry than go running
4. Negligent, attentive mouse mothers show biological differences
5. Scientists successfully treat new mouse model of inflammatory bowel disease
6. Book is the first high-resolution digital mouse brain atlas designed for Web applications
7. Dissecting the genetic components of adaptation of E. coli to the mouse gut
8. CSHL scientists identify and repress breast cancer stem cells in mouse tissue
9. New chimeric mouse model for human liver diseases, drug testing
10. Looking through the eyes of a mouse, scientists monitor circulating cells in its bloodstream
11. Cancer-resistant mouse discovered
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/17/2015)... 17, 2015  NXT-ID, Inc. (NASDAQ: NXTD ) ... on the growing mobile commerce market and creator of ... for Q4 2015. The new marketing campaign is being ... Amplitude Marketing Group ( http://amplitudemarketing.com/ ) and TPMG ( ... leader in retail driven marketing and brand awareness and ...
(Date:8/11/2015)... 11, 2015 Today, ZUK announced its Android ... well as expected revenues in 2015 that relate to sales of ... guidance of approximately 2,200 MSEK for 2015. Jörgen Lantto, ... prominent smartphone manufacturer in China ... selected FPC1 155 for Z1 ...
(Date:8/6/2015)... SAN JOSE, Calif. , Aug. 6, 2015 ... the leading developer of human interface solutions, today ... and TouchPad technologies on Windows 10. Microsoft leveraged ... fundamental to the operating system. ... and drivers are fully certified with Microsoft,s Precision ...
Breaking Biology News(10 mins):NXT-ID, Inc. Launches Sales Campaign for Wocket Smart Wallet with Award Winning Marketing Team 2NXT-ID, Inc. Launches Sales Campaign for Wocket Smart Wallet with Award Winning Marketing Team 3FPC's Touch Fingerprint Sensor FPC1155 in ZUK's Smartphone Z1 2Synaptics Chosen for Human Interface Co-Development on Windows 10 2
... VA As the Colorado River winds through the Colorado ... of sediment. This sediment which once left the river,s ... Colorado "the reddish river" is a vital component to ... of the Hoover and Glen Canyon dams, which trap the ...
... significant upgrade that would enable it to produce high-quality, ... key material by a team of researchers that includes ... Texas A&M University. The material, which converts ... to produce an image, is the result of a ...
... Vulcan mind meld to share cognition: Virginia Tech Carilion ... and hot feelings may be more intimately connected than previously ... parts, like Spock, and separate emotional parts, like Kirk. But ... , director of the Human Neuroimaging Laboratory at ...
Cached Biology News:Texas A&M research contributes to improved ultrasound imaging 2Kirk, Spock together: Putting emotion, logic into computational words 2
(Date:9/3/2015)... , Sept. 3, 2015  Guardant Health®, the ... abstracts highlighting the performance and clinical utility of ... for oral and poster presentations at the International ... World Conference on Lung Cancer. These abstracts were ... of California, Davis; the University of Chicago; Sarah ...
(Date:9/3/2015)... , September 3, 2015 According ... by System (LC (HPLC, UHPLC, Flash), GC, Other Components ... Syringe Filters, Vials) - Analysis & Global Forecasts to ... expected to reach around 9.223 Billion by 2020 from ... 5.5%. Browse 141 tables and 36 figures ...
(Date:9/2/2015)... , Sept. 2, 2015 Axovant Sciences Ltd. ... treatment of dementia, today announced upcoming presentations at three investor ... at the Baird 2015 Healthcare Conference in New ... , Thursday, September 10 at 2:00 PM at the BioCentury ... the Millennium Broadway Hotel & Conference Center , Thursday, ...
(Date:9/2/2015)... Sep. 02, 2015 ... the addition of Jain PharmaBiotech,s new report ... to their offering. This report ... technologies and applications. The report starts with a ... of markets. Technologies include array comparative genomic hybridization ...
Breaking Biology Technology:Leading Cancer Centers to Present Clinical Utility Data For Guardant360 At IASLC's 16th World Conference on Lung Cancer in Denver Sept. 6-9 2Leading Cancer Centers to Present Clinical Utility Data For Guardant360 At IASLC's 16th World Conference on Lung Cancer in Denver Sept. 6-9 3Leading Cancer Centers to Present Clinical Utility Data For Guardant360 At IASLC's 16th World Conference on Lung Cancer in Denver Sept. 6-9 4Chromatography Instruments Market Worth $ 9.223 Billion by 2020 2Chromatography Instruments Market Worth $ 9.223 Billion by 2020 3Chromatography Instruments Market Worth $ 9.223 Billion by 2020 4Axovant Sciences To Present At Upcoming Investor Conferences 2Axovant Sciences To Present At Upcoming Investor Conferences 3Global Biochips and Microarrays Technologies, Markets and Companies Report 2015 with Market Size in 2014 and Projected Value for the Years 2019 and 2024 2
... HARRISBURG, Pa., Oct. 20 PresentCare, a technology ... AdherencePlus(TM) solution, an innovative approach to assist the ... medication non-adherence. The AdherencePlus solution is comprised ... communication technology combined with unprecedented human touch. Both ...
... , ROME, October 20 ... of World Osteoporosis Day, International Osteoporosis Foundation,(IOF) CEO ... the,globe to join the fight against osteoporosis. "Osteoporosis ... afford to ignore. Immediate measures must,be taken to ...
... 19 /PRNewswire-Asia-FirstCall/ -- Lotus Pharmaceuticals, Inc.,(OTC Bulletin Board: LTUS) ("Lotus" ... and licensed national seller of pharmaceutical,products in the People,s Republic ... Lotus,s priorities for the balance of 2009 are, ... do for its most valuable customers, ...
Cached Biology Technology:Medication Adherence Technology Combines with Patient Outreach Program to Yield Healthier Populations and Reduce Healthcare Costs 2Medication Adherence Technology Combines with Patient Outreach Program to Yield Healthier Populations and Reduce Healthcare Costs 3World Osteoporosis Day Call for Immediate Action to Prevent Fractures 2Lotus Pharmaceuticals, Inc. Announces 2010 Growth Strategy 2Lotus Pharmaceuticals, Inc. Announces 2010 Growth Strategy 3Lotus Pharmaceuticals, Inc. Announces 2010 Growth Strategy 4
Parathyroid Hormone Receptor 2 [PTHR2]...
... a member of the caudal-related homeobox family, ... both proliferation and differentiation in intestinal epithelial ... triggering cells towards the phenotype of differentiated ... maintenance of the phenotype. Clone CDX2-88 reacts ...
... a G1 cyclin required for G1-phase progression ... proto-oncogene. cyclin D2 can phosphorylate pRB ... Reactivity: Human, Mouse, and Rat. ... particularly well suited for neutralization of cyclin ...
... Immunogen: Synthetic ... 22-37 SGHKSEEKREKMKRTL Antigen Family: ... signalling; Antigen Subfamily: ... signalling Recommended Storage: ...
Biology Products: