Navigation Links
Disabling enzyme allows mice to gorge without becoming obese, new study finds
Date:1/11/2009

Berkeley -- Researchers at the University of California, Berkeley, have identified a new enzyme that plays a far more important role than expected in controlling the breakdown of fat. In a new study to be published Jan. 11 in the journal Nature Medicine, researchers report that mice that have had this enzyme disabled remained lean despite eating a high-fat diet and losing a hormone that suppresses appetite.

"We have discovered a new enzyme within fat cells that is a key regulator of fat metabolism and body weight, making it a promising target in the search for a treatment for human obesity," said Hei Sook Sul, UC Berkeley professor of nutritional sciences and toxicology and principal investigator of the research.

Sul's research team includes the three co-lead authors of the paper, all from UC Berkeley's Department of Nutritional Sciences and Toxicology: Kathy Jaworski, former post-doctoral researcher; Maryam Ahmadian, graduate student; and Robin Duncan, post-doctoral fellow.

The enzyme in the spotlight, adipose-specific phospholipase A2 (AdPLA), is found in abundance only in fat tissue. AdPLA sets off a chain of events that increases levels of a signaling molecule called prostaglandin E2 (PGE2), which suppresses the breakdown of fat. Mice that have no AdPLA have lower PGE2 levels and a higher rate of fat metabolism.

"When levels of PGE2 are decreased because of the lack of AdPLA, fat breakdown proceeds unchecked, resulting in leanness even in animals that eat all day long," said co-lead author Duncan.

In the study, mice that had the gene for AdPLA expression knocked out were compared with a control group of normal mice. As soon as the mice were weaned at about 3 weeks of age, researchers began offering the two groups of mice an all-you-can-eat buffet of tasty, high-fat foods.

Notably, the enzyme did not appear to affect appetite since the two groups ate equivalent amounts. However, as the mice aged, t
'/>"/>

Contact: Sarah Yang
scyang@berkeley.edu
510-643-7741
University of California - Berkeley
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Study reveals 2 genes linked to disabling arthritis
2. Disabling mouse enzyme increases fertility
3. Green tea boosts production of detox enzymes, rendering cancerous chemicals harmless
4. MGH researchers describe new way to identify, evolve novel enzymes
5. Enzyme alerts cells powerful army to repair DNA damage
6. Scientists learn structure of enzyme in unusual virus
7. Scientists spy enzyme that makes us unique
8. Unlocking the function of enzymes
9. A key enzyme helps keep the synapse on track
10. Team of chemists receives $5 million grant to develop enzyme mimics
11. Iowa State researcher studies how enzymes break down cellulose
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/6/2015)... Conn. , Apr. 6, 2015 NXT-ID, ... "Company"), a biometric authentication company focused on the ... has filed provisional patent 62/143028 for ... COMMUNICATIONS AND ENERGY TRANSFER  NXT-ID introduces a ... payments. This patent surrounds the use of miniature ...
(Date:4/2/2015)... -- At its 2015 ACMG Annual Clinical Genetics Meeting ... American College of Medical Genetics and Genomics (ACMG) announced ... Members of the ACMG Board of Directors serve as ... its policies and programs. ACMG is the national organization ... eventful time in medical genetics and genomics.  We are ...
(Date:4/2/2015)... GOTHENBURG, Sweden , April 2, 2015 ... for its touch fingerprint sensor FPC1025 from the distributor ... Deliveries will commence during Q2 2015 although the major ... 2015. The sensors will be used by smartphone manufacturers ... of 110 MSEK is included in the communicated revenue ...
Breaking Biology News(10 mins):NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 2NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 3NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 4American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 2American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 3American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 4American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 5American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 6American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 7American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 8Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 110 Million 2
... Institutes of Health Director Francis S. Collins, M.D., Ph.D., today ... new director of the National Institute of General Medical Sciences. ... of the Department of Biology at the Massachusetts Institute of ... spring of 2012. "Dr. Kaiser has tremendous energy and ...
... A new study has shown that racehorses are extremely ... can adapt very quickly to sudden shifts in the 24-hour ... with unexpected benefits on their physical performance. The ... of Medical and Veterinary Sciences is published in the ...
... On the heels of a summit on managing extreme events ... National Academy of Sciences and the Willis Research Network, part ... headquartered in the U.K., pledged to continue exploring activities aimed ... extreme events. Although 2011 has been a notable year ...
Cached Biology News:Cell biologist Chris A. Kaiser to lead NIH's National Institute of General Medical Sciences 2Cell biologist Chris A. Kaiser to lead NIH's National Institute of General Medical Sciences 3Light dependency underlies beneficial jetlag in racehorses 2Light dependency underlies beneficial jetlag in racehorses 3US science academy and global reinsurance broker spark 2US science academy and global reinsurance broker spark 3US science academy and global reinsurance broker spark 4
(Date:5/5/2015)... , May 5, 2015 Roka Bioscience, Inc. ... providing advanced testing solutions for the detection of foodborne pathogens, ... at the Bank of America Merrill Lynch 2015 Health Care ... be held at Encore at the Wynn, Las ... of the presentation will be available through the investor relations ...
(Date:5/5/2015)... , May 5, 2015 Psyche Systems Corporation ... which offers a first-of-its-kind platform that helps labs comply ... lab results, transforms the way patients engage with these ... Luminate Health provides a HIPAA-compliant digital platform that ... manage, and understand their lab results, and uniquely connects ...
(Date:5/5/2015)... 5, 2015 ImmunoCellular Therapeutics, Ltd. ("ImmunoCellular") ... , President and Chief Executive Officer, will present ... DATE:  Thursday, May 7, 2015     TIME:  11:30 am ... > click the red "register/ watch presentations" button ... online event where investors are invited to ask ...
(Date:5/5/2015)... , May 05, 2015 Research and ... the addition of the "Clinical Laboratory, Molecular ... Forecasts 2015 to 2019 - Europe Version" ... developments especially in the area of molecular diagnostics ... growing and evolving world market that is moving ...
Breaking Biology Technology:Psyche Systems Corporation Forms Strategic Alliance with Luminate Health to Provide First-of-its-kind Patient Access Solution 2Psyche Systems Corporation Forms Strategic Alliance with Luminate Health to Provide First-of-its-kind Patient Access Solution 3ImmunoCellular Therapeutics to Webcast Live at VirtualInvestorConferences.com on May 7 2European Clinical Laboratory, Molecular Diagnostics and Genomic Testing Services Market 2015-2019 2
... at the Midwest Venture Summit on May 20 in Chicago. ... selecting only a handful of presenters out of the applicants ... be reviewed by a panel of investors that has been ... that each company is producing and developing, as well as ...
... company moving to Madison from Chicago is being welcomed ... , ,Governor Jim Doyle announced earlier this week that ... the Department of Commerce Technology Venture Fund ... to help the company purchase new equipment and hire ...
... system. Image courtesy of GE Healthcare. Wisconsin Governor ... $10 million for a grant and loan program to ... , ,"I am committed to ensuring that all Wisconsin ... I am pleased to unveil a proposal of my ...
Cached Biology Technology:Follow the money 2Follow the money 3Doyle proposes $10M to expand use of electronic medical records 2Doyle proposes $10M to expand use of electronic medical records 3
...
... Kit contains reagents required to perform a ... the bisulfite reaction, all unmethylated cytosines are ... while 5-methylcytosines remain unaltered. Thus, the sequence ... on whether the DNA is originally methylated ...
... contains a unique β-agarose digesting enzyme developed ... intact DNA and RNA from low melting ... TAE, TBE, MOPS, or phosphate buffers. The ... TAE, TBE, MOPS, and phosphate electrophoresis buffers ...
...
Biology Products: