Navigation Links
Diffusion of a soluble protein through a sensory cilium
Date:2/22/2010

A team of researchers led by Peter Calvert (SUNY Upstate Medical University) has, for the first time, measured the diffusion coefficient of a protein in a primary cilium and in other major compartments of a highly polarized cell. The study appears in the March issue of the Journal of General Physiology (www.jgp.org).

Transport of proteins to and from cilia is crucial for normal cell function and survival, and interruption of transport has been implicated in degenerative diseases and neoplastic diseases, such as cancer. Researchers believe that cilia impose selective barriers to the movement of proteins, but because of the narrow and complex structure of ciliawith diameters near or below the resolution of light microscopythis hypothesis has been difficult to examine.

Using confocal and multiphoton microscopy, Calvert and his teamincluding William Schiesser (Lehigh University) and Edward Pugh (University of California, Davis)measured the mobility of PAGFP (photoactivatable green fluorescent protein) in the connecting cilium (CC) of retinal rod photoreceptors in frogs, as well as in the subcellular compartments bridged by the CC. In addition, the team measured the overall time for the protein concentration to equilibrate within and between compartments.

The results establish that the CC does not pose a major barrier to protein diffusion within the rod cell, but that the axial diffusion in each of the rod's compartments is substantially delayed relative to that in aqueous solution.


'/>"/>

Contact: Rita Sullivan
news@rupress.org
212-327-8603
Rockefeller University Press
Source:Eurekalert  

Page: 1

Related biology news :

1. The impact of the diffusion of maize to the Southwestern United States
2. MDC researchers link protein tether to touch perception
3. Computer simulation of protein malfunction related to Alzheimers disease
4. Bacteria-killing proteins cover blood type blind spot
5. Barley protein concentrate could replace fishmeal in aquaculture feeds
6. Argonautes: A big turn-off for proteins
7. Researchers correct the record about behavior of important human protein tied to cancer
8. Illuminating protein networks in 1 step
9. Notre Dame study focuses on protein dynamics
10. Membrane-coat proteins: Bacteria have them too
11. Protein supplements are misused by athletes
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Diffusion of a soluble protein through a sensory cilium
(Date:5/6/2017)... -- RAM Group , Singaporean based technology ... biometric authentication based on a novel  quantum-state ... perform biometric authentication. These new sensors are based on a ... Group and its partners. This sensor will have widespread ... security. Ram Group is a next generation sensor ...
(Date:4/17/2017)... MELBOURNE, Florida , April 17, 2017 ... security technology company, announces the filing of its 2016 Annual Report ... Securities and Exchange Commission. ... Report on Form 10-K is available in the Investor Relations section ... well as on the SEC,s website at http://www.sec.gov . ...
(Date:4/11/2017)... Research and Markets has announced the addition of the "Global ... ... at a CAGR of 30.37% during the period 2017-2021. ... based on an in-depth market analysis with inputs from industry experts. ... the coming years. The report also includes a discussion of the ...
Breaking Biology News(10 mins):
(Date:6/22/2017)... ... June 22, 2017 , ... Charm Sciences, Inc. is pleased to ... was determined to be appropriate as a screening test at dairies and farms for ... EZ system, and the Charm EZ Lite system. These systems are a combination incubator ...
(Date:6/20/2017)... , ... June 20, 2017 , ... ... immediately determine the adulterants which pose the most likely threat to their products ... of this year. , IFT's annual food expo attracts over 20,000 attendees ...
(Date:6/20/2017)... (PRWEB) , ... June 20, 2017 , ... Do More ... the transition from being a trusted supplier in the weighing industry, to extending its ... extractions, ELISA essays, enzyme reactions, immunoassays, hybridizations and more, allowing for its customers ...
(Date:6/19/2017)... NJ (PRWEB) , ... June 19, 2017 , ... ... innovative solutions for clinical development reported today that it is launching two new ... The company will be demonstrating new capabilities at the DIA 2017 Annual Meeting ...
Breaking Biology Technology: