Navigation Links
Different genes behind same adaptation to thin air
Date:12/6/2012

Highlanders in Tibet and Ethiopia share a biological adaptation that enables them to thrive in the low oxygen of high altitudes, but the ability to pass on the trait appears to be linked to different genes in the two groups, research from a Case Western Reserve University scientist and colleagues shows.

The adaptation is the ability to maintain a relatively low (for high altitudes) level of hemoglobin, the oxygen-carrying protein in red blood cells. Members of ethnic populations - such as most Americans - who historically live at low altitudes naturally respond to the thin air by increasing hemoglobin levels. The response can help draw oxygen into the body, but increases blood viscosity and the risks for thrombosis, stroke and difficulties with pregnancies.

By revealing how populations can live in severe environments, the research may provide insight for managing high-altitude sickness and for treating low blood-oxygen conditions such as asthma, sleep apnea, and heart problems among all people.

How long such physiological and genetic changes take remains a question. The researchers found the adaptation in an ethnic group that has lived high in mountains of Ethiopia for at least 5,000 years, but not among a related group that has lived high in the mountains for 500 years.

The findings are reported today in the open-access online journal PLoS Genetics.

In their first comparison, the researchers found that the genes responsible for hemoglobin levels in Tibetans don't influence an ethnic group called the Amhara

The Amhara have lived more than a mile high in the Semien Mountains of northern Ethiopia for 5,000 to 70,000 years. A different variant on the Amhara genome, far away from the location of the Tibetan variant, is significantly associated with their low hemoglobin levels.

"All indications are we're seeing convergent evolution," said Cynthia Beall, professor of anthropology at Case Western Reserv
'/>"/>

Contact: Kevin Mayhood
kevin.mayhood@case.edu
216-368-4442
Case Western Reserve University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Neuroscientists prove ultrasound can be tweaked to stimulate different sensations
2. Study suggests different organ-derived stem cell injections improve heart function
3. Lack of nutrients and metabolic syndrome linked to different subtypes of depression
4. Yeast protein breaks up amyloid fibrils and disease protein clumps differently
5. Import of proteins into chloroplasts is differentially regulated by age
6. Men and women are different in terms of genetic predispositions
7. How to Differentiate Your Pharmaceutical Product in the Personalized Medicine Segment
8. The eyes have it: Men do see things differently to women
9. Breast milk promotes a different gut flora growth than infant formulas
10. The first ant methylomes uncover the relationship between DNA methylation and caste differentiation
11. Same adaptations evolve across different insects
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)...  Pomerantz LLP has filed a class action ... "Company")(NYSE-MKT: PVCT) and certain of its officers.  The ... Middle District of Tennessee , ... consisting of all persons or entities who purchased ... 2013 and May 22, 2014, both dates inclusive ...
(Date:7/10/2014)... July 2, 2014 NXT-ID, Inc., (OTCQB: NXTD) a biometric authentication ... Mr. Gino Pereira was interviewed on July 1 ... Tampa Florida . Mr. Pereira discusses the company,s ... Harris and how the Wocket™ aims to replace a ... Cedric Harris tells Gino he has never ...
(Date:7/10/2014)... Fingerprint Cards, (FPC,s) new ... (DW). An Asian OEM has selected FPC1021 for a flagship ... August 2014.   FPC is proud to announce ... planned date for start of mass production in August 2014. ... 5M, for delivery in the first half of July. The ...
Breaking Biology News(10 mins):SHAREHOLDER ALERT: Pomerantz Law Firm Announces the Filing of a Class Action against Provectus Biopharmaceuticals, Inc. and Certain Officers - PVCT 2SHAREHOLDER ALERT: Pomerantz Law Firm Announces the Filing of a Class Action against Provectus Biopharmaceuticals, Inc. and Certain Officers - PVCT 3Security and Your Money: Tampa Bay Radio Host Cedric Harris Talks to NXT-ID CEO Mr. Gino Pereira about the Wocket Smart Wallet 2Security and Your Money: Tampa Bay Radio Host Cedric Harris Talks to NXT-ID CEO Mr. Gino Pereira about the Wocket Smart Wallet 3Security and Your Money: Tampa Bay Radio Host Cedric Harris Talks to NXT-ID CEO Mr. Gino Pereira about the Wocket Smart Wallet 4FPC Wins DW and Initial Ramp Order for FPC1021 Touch Sensor for Flagship Smartphone from Asian OEM 2
... similar small molecules appear capable of protecting cells ... RELEVANCE: Parkinson,s disease is a neurodegenerative ... movements. There is currently no cure for the ... symptoms, not the disease,s cellular cause. Small ...
... London, New Delhi, Singapore and Washington DC (Dec 28, 2010) ... individual,s identify with political parties , according to an article ... the official journal of the Western Political Science Association (published ... most studied concepts in modern political science. Scholars have long ...
... during early development when future spinal cord cells growing in ... In the Dec. 6 issue of Nature Cell Biology ... team with colleagues at the University of California, Berkeley to ... spinal cord development, a discovery that opens new doors for ...
Cached Biology News:Small molecules found to protect cells in multiple models of Parkinson's disease 2Small molecules found to protect cells in multiple models of Parkinson's disease 31 step closer to closure 2
(Date:7/10/2014)... Faso (PRWEB) July 10, 2014 ... today have access to an additional family planning ... access to contraception at all levels of the ... lower-dose formulation of a widely used contraceptive—Pfizer’s Depo-Provera® ... , Burkina Faso is the first of four ...
(Date:7/10/2014)... San Francisco, CA (PRWEB) July 10, 2014 ... a family closer together. The Archer Family purchased ... information contained within DNA, but ended up with a ... surprising discoveries contained within the family members’ DNA genuinely ... family had decided to search deeper into genetic history ...
(Date:7/10/2014)... , July 10, 2014  Franciscan St. ... of capnography for respiratory monitoring outside the ... healthcare leaders in embracing state-of-the-art patient safety ... patients are breathing and can alert medical ... measuring the amount of carbon dioxide the ...
(Date:7/10/2014)...   Ceres, Inc . (Nasdaq: CERE ... financial results for the three months ended May 31, ... Ceres reported that the company and its customers ... season in Brazil, which concluded in June, despite dry ... areas for part of the growing season. Yields of ...
Breaking Biology Technology:Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 2Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 3Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 4Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 5Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 6Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 2Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 3Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 4Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 5Franciscan St. Anthony Health-Crown Point Underscores Patient Safety Commitment Through Expanded Use of Capnography 2Ceres Announces Fiscal Third Quarter 2014 Financial Results 2Ceres Announces Fiscal Third Quarter 2014 Financial Results 3Ceres Announces Fiscal Third Quarter 2014 Financial Results 4Ceres Announces Fiscal Third Quarter 2014 Financial Results 5Ceres Announces Fiscal Third Quarter 2014 Financial Results 6Ceres Announces Fiscal Third Quarter 2014 Financial Results 7Ceres Announces Fiscal Third Quarter 2014 Financial Results 8Ceres Announces Fiscal Third Quarter 2014 Financial Results 9
... RIDGE, Tenn., Feb. 4, 2010 -- Four Oak Ridge ... will receive five-year research grants as part of the ... The $85 million program, funded under the American Recovery ... is designed to support exceptional researchers during the crucial ...
... , ... and HEALTHeCAREERS Network , leading employment communities for ... career sites recently recognized by recruiters and job seekers. , ... ) , The same audiences have chosen Hcareers for the ...
... ... Opportunities and Challenges of Maize Cultivation Under Dry Conditions , ... Bordeaux, France (Vocus) February 4, 2010 -- ... develop drought-tolerant crops, which will play a major role in sustainably increasing agricultural productivity, ...
Cached Biology Technology:4 ORNL researchers selected for Recovery Act early career funds 24 ORNL researchers selected for Recovery Act early career funds 3Industry Web Sites Continue to Win Online Award 2Industry Web Sites Continue to Win Online Award 3DuPont Leader: Drought-Tolerant Crops Developed Through Modern Breeding are Key to Sustainably Increasing Grain Production 2
Non-Receptor Tyrosine Kinase Sampler Kit 10 mu g each...
... phase reagent for Virus ... & unique water insoluble ... detergents and chaotropes; Engineered ... non-envelop viruses while preserving ...
PKA Sampler Kit 10 mu g each...
Rabbit polyclonal to BCA1 ( Abpromise for all tested applications). Antigen: Generated using E.coli expressed mouse BCA1. Entrez GeneID: 10563 SWISS Protein ID: O43927...
Biology Products: