Navigation Links
Different genes behind same adaptation to thin air
Date:12/6/2012

Highlanders in Tibet and Ethiopia share a biological adaptation that enables them to thrive in the low oxygen of high altitudes, but the ability to pass on the trait appears to be linked to different genes in the two groups, research from a Case Western Reserve University scientist and colleagues shows.

The adaptation is the ability to maintain a relatively low (for high altitudes) level of hemoglobin, the oxygen-carrying protein in red blood cells. Members of ethnic populations - such as most Americans - who historically live at low altitudes naturally respond to the thin air by increasing hemoglobin levels. The response can help draw oxygen into the body, but increases blood viscosity and the risks for thrombosis, stroke and difficulties with pregnancies.

By revealing how populations can live in severe environments, the research may provide insight for managing high-altitude sickness and for treating low blood-oxygen conditions such as asthma, sleep apnea, and heart problems among all people.

How long such physiological and genetic changes take remains a question. The researchers found the adaptation in an ethnic group that has lived high in mountains of Ethiopia for at least 5,000 years, but not among a related group that has lived high in the mountains for 500 years.

The findings are reported today in the open-access online journal PLoS Genetics.

In their first comparison, the researchers found that the genes responsible for hemoglobin levels in Tibetans don't influence an ethnic group called the Amhara

The Amhara have lived more than a mile high in the Semien Mountains of northern Ethiopia for 5,000 to 70,000 years. A different variant on the Amhara genome, far away from the location of the Tibetan variant, is significantly associated with their low hemoglobin levels.

"All indications are we're seeing convergent evolution," said Cynthia Beall, professor of anthropology at Case Western Reserv
'/>"/>

Contact: Kevin Mayhood
kevin.mayhood@case.edu
216-368-4442
Case Western Reserve University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Neuroscientists prove ultrasound can be tweaked to stimulate different sensations
2. Study suggests different organ-derived stem cell injections improve heart function
3. Lack of nutrients and metabolic syndrome linked to different subtypes of depression
4. Yeast protein breaks up amyloid fibrils and disease protein clumps differently
5. Import of proteins into chloroplasts is differentially regulated by age
6. Men and women are different in terms of genetic predispositions
7. How to Differentiate Your Pharmaceutical Product in the Personalized Medicine Segment
8. The eyes have it: Men do see things differently to women
9. Breast milk promotes a different gut flora growth than infant formulas
10. The first ant methylomes uncover the relationship between DNA methylation and caste differentiation
11. Same adaptations evolve across different insects
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... have built the first smartphone app that automatically ... trends. In other words, your smartphone knows your ... -- and how that affects you. , The ... and loneliness to their academic performance, also may ... example, to monitor mental health, trigger intervention and ...
(Date:9/18/2014)... 18, 2014Many Americans across racial and ethnic groups ... impact on their day-to-day life, more so than ... and speech (57% of African-Americans, 49% of non-Hispanic ... When asked which disease or ailment is the ... first among African-Americans followed by AIDS/HIV. Hispanics ...
(Date:9/18/2014)... several disciplines will be celebrated tonight at the third ... improving the health of premature infants and in paving ... researchers, whose work was supported by the National Science ... Atomic Energy Commission, will be honored at a ceremony ... bipartisan group of Members of Congress will be on ...
Breaking Biology News(10 mins):New Dartmouth smartphone app reveals users' mental health, performance, behavior 2New Dartmouth smartphone app reveals users' mental health, performance, behavior 3New Dartmouth smartphone app reveals users' mental health, performance, behavior 4Americans rate losing eyesight as having greatest impact on their lives 2Americans rate losing eyesight as having greatest impact on their lives 33rd annual Golden Goose award ceremony honors 8 researchers; Unusual work had big results 2
... who initially survive a heart attack, a significant cause of ... literally, bursting of the heart wall. A new ... as the key player in the biochemical cascade that leads ... Advance Online Publication (AOP) of the journal Nature Medicine, ...
... new study, led by PRBO Conservation Science (PRBO), projects a ... sea-level rise scenarios that are increasingly likely. PRBO and ... San Francisco Bay,s tidal marsh could be lost in the ... sea-level rise, low sediment availability and no significant restoration]. ...
... are started in-ground, then sold as bare-root ,liners, to ... To minimize wind damage and to facilitate transport from ... buried deeper than necessary. This deep planting of liners ... important foundations of root systems responsible for trees, health ...
Cached Biology News:Study explains how heart attack can lead to heart rupture 2Study explains how heart attack can lead to heart rupture 3Bleak future for Bay area tidal marshes? 2Bleak future for Bay area tidal marshes? 3Bleak future for Bay area tidal marshes? 4Planting depth's effect on container-grown trees 2
(Date:9/19/2014)... , September 19, 2014 BioTech ... developments, patents and results of studies and trials.  Companies ... and Company (NYSE: LLY ), Gilead Sciences ... CELG ) and Arena Pharmaceuticals Inc. (NASDAQ: ... in developing prodrug therapeutics for the treatment of cancer, ...
(Date:9/19/2014)... September 19, 2014 The new , ... , available today on PharmaBoardroom.com for ... crisis that rocked the Spanish economy in 2009, and the ... community has remained pragmatic in times of trouble. ... the fifth biggest European market, and the general conditions to ...
(Date:9/18/2014)... A novel robotic system that can operate ... being tested as part of a biomedical research partnership ... the aim of determining if the robot, in conjunction ... faster, more accurate, less costly, and less discomforting for ... to deliver prostate cancer therapies with greater precision. , ...
(Date:9/18/2014)... Research and Markets has announced ... Cell Industry Report, 2014-2017" report to their offering. ... that can differentiate into specialized cells and can divide ... therapy can be applied to treatment of cardiovascular diseases, ... diseases, damage or lesion of liver, kidney and other ...
Breaking Biology Technology:Biotech Companies Pushing Sector Higher With Recent Therapeutic Advancements & Patent Approvals - Company Wins Summary Judgment For Prodrug Patent 2Biotech Companies Pushing Sector Higher With Recent Therapeutic Advancements & Patent Approvals - Company Wins Summary Judgment For Prodrug Patent 3Biotech Companies Pushing Sector Higher With Recent Therapeutic Advancements & Patent Approvals - Company Wins Summary Judgment For Prodrug Patent 4Biotech Companies Pushing Sector Higher With Recent Therapeutic Advancements & Patent Approvals - Company Wins Summary Judgment For Prodrug Patent 5Biotech Companies Pushing Sector Higher With Recent Therapeutic Advancements & Patent Approvals - Company Wins Summary Judgment For Prodrug Patent 6Biotech Companies Pushing Sector Higher With Recent Therapeutic Advancements & Patent Approvals - Company Wins Summary Judgment For Prodrug Patent 7PharmaBoardroom Releases New Spain Pharmaceuticals Report 2PharmaBoardroom Releases New Spain Pharmaceuticals Report 3Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 2Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 3Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 4Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 5Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 6Global and Chinese Stem Cell Industry Report, 2014-2017 2Global and Chinese Stem Cell Industry Report, 2014-2017 3
... Telik, Inc.,(Nasdaq: TELK ) announced that the ... partial hold on TELCYTA(R) (canfosfamide HCl, TLK286),clinical trials. ... data by,the agency and permits the resumption of ... Alto, CA is a biopharmaceutical company focused on,discovering, ...
... Show Lower Dose Associated with Fewer Adverse Events in Healthy ... ... ,GlaxoSmithKline,s (NYSE: GSK ) HIV protease inhibitor LEXIVA(R),(fosamprenavir calcium) may now ... level of protease inhibitors in the,bloodstream. The U.S. Food and Drug ...
... Standards, HOFFMAN ESTATES, Ill., Oct. 12 ... which failed quality testing,ConsumerLab.com anonymously purchased, tested and ... CNCA, a leading national distributor,of premium dietary supplements ... health and wellness., "ConsumerLab.com testing showed that ...
Cached Biology Technology:FDA Removes Partial Hold on TELCYTA Clinical Development 2FDA Approves Administration of LEXIVA(R) with Lower Dose of 'Boosting' Medication Ritonavir 2FDA Approves Administration of LEXIVA(R) with Lower Dose of 'Boosting' Medication Ritonavir 3FDA Approves Administration of LEXIVA(R) with Lower Dose of 'Boosting' Medication Ritonavir 4CNCA Exceeds Standards in Nutritional Supplement Quality, Protects Public 2CNCA Exceeds Standards in Nutritional Supplement Quality, Protects Public 3
UltraPure DNase/RNase-Free Distilled Water is designed for use in all molecular biology applications. It is 0.1-m membrane-filtered and tested for DNase and RNase activity....
...
Water Distilled (Gibco™) is membrane filtered and endotoxin screened....
Immunogen: Human Respiratory Syncytial Virus (RSV) and Bovine Respiratory Syncytial Virus (BRSV) Fusion protein Storage: -20 C, Avoid Freeze/Thaw Cycles...
Biology Products: