Navigation Links
Differences in jet lag severity could be rooted in how circadian clock sets itself
Date:10/13/2011

It's no secret that long-distance, west-to-east air travel Seattle to Paris, for example can raise havoc with a person's sleep and waking patterns, and that the effects are substantially less pronounced when traveling in the opposite direction.

Now researchers, including a University of Washington biologist, have found hints that differing molecular processes in an area of the brain known as the suprachiasmatic nucleus might play a significant role in those jet lag differences.

Human circadian clocks operate on a period about 20 minutes longer than one day and so must be synchronized to the light-dark cycle of the solar day, delaying or advancing their time in response to light.

Someone whose clock runs faster than a solar day must delay it on a daily basis, and someone whose clock runs slower than a solar day must advance it. These daily adjustments happen naturally, and without our noticing, but the process is disrupted by sudden large shifts in the light-dark cycle because of a radically new geographic location.

Researchers previously learned that delaying the circadian clock happens through different pathways in the suprachiasmatic nucleus than advancing the clock does. The new research shows that, at a molecular level, the mechanisms responsible for resetting the expression of the "clock genes" are drastically different.

"We have known for decades that, in humans and other organisms, advances are always much harder to achieve than delays. For example, compare jet lag going to Europe with that coming back," said Horacio de la Iglesia, a UW associate professor of biology.

"One of the reasons may be that these two forms of resetting the clock involve different molecular mechanisms at the clock level," he said.

de la Iglesia and William Schwartz of the University of Massachusetts Medical School are corresponding authors of a paper detailing the research, published online recently (Oct. 3)
'/>"/>

Contact: Vince Stricherz
vinces@uw.edu
206-543-2580
University of Washington
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers note differences between people and animals on calorie restriction
2. Study sheds light on genetic differences that cause a childhood eye disease
3. Study identifies genetic variants giving rise to differences in metabolism
4. Genetic differences between yeasts greater than those between humans and chimpanzees
5. Differences in neighborhood food environment may contribute to disparities in obesity
6. Differences among exercisers and nonexercisers during pregnancy
7. Differences among exercisers and nonexercisers during pregnancy
8. Risk of vibration-induced vascular injuries linked to vibration frequency differences
9. Tiny differences in our genes help shed light on the big picture of human history
10. Geography and history shape genetic differences in humans
11. Scientists demonstrate importance of niche differences in biodiversity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... One day about eight years ago, Katia Silvera ... and her father were on a field trip in a ... orchid they had never seen before. , Unable to identify ... The orchid turned out to be an unnamed species. ... silverarum . , "Lophiaris" is the genus name, comprising about ...
(Date:4/17/2014)... Several parasites and pathogens that devastate honeybees in Europe, ... Africa, but do not appear to be impacting native ... team of researchers., The invasive pests include including ... East African honeybees appear to be resilient to these ... used to control pests in Europe, Asia and the ...
(Date:4/17/2014)... such as heart disease, epilepsy and pain, making them ... is still much scientists do not know about the ... into the structure of sodium channels and, specifically, one ... responsible for ,fine-tuning, the activity of the channel. The ... the Journal of Biological Chemistry . , Nerves ...
Breaking Biology News(10 mins):Orchid named after UC Riverside researcher 2Orchid named after UC Riverside researcher 3East African honeybees are safe from invasive pests… for now 2East African honeybees are safe from invasive pests… for now 3Structure of sodium channels different than previously believed 2
... and evolution of humanity, from early hominid to dominant ... but of our planet. To chronicle this epic narrative ... from the George Washington University, presents the Wiley-Blackwell Encyclopedia ... understanding of mankind,s ancient history. Over two ...
... has been developed to carry out preimplantation genetic screening ... to the recipient uterus in the same in vitro ... The technique has been applied to the ... age, recurrent miscarriages or repeated implantation failures. ...
... 2011 Lockheed Martin (NYSE: LMT ) ... Integrations "Company of the Year" by Frost and Sullivan, ... that offer high levels of customer value. ... biometric solutions that play an important role our customer,s ...
Cached Biology News:Improvements in embryonic preimplantation genetic screening techniques 2Lockheed Martin Named Biometrics "Company of the Year" by Frost and Sullivan 2
(Date:1/14/2014)... 14, 2014 iLab Solutions, the leader in ... new Director of Product Strategy. In this role, Michelle will ... sub-teams to guide in the development of iLab products. Her ... maximum possible benefit to the scientific community by offering the ...
(Date:1/14/2014)... Jan. 14, 2014  RXi Pharmaceuticals Corporation (OTCQX: RXII), ... commercializing innovative therapies addressing major unmet medical needs ... the Notice of Allowance from the United States ... RNAi compounds (sd-rxRNA®), for the treatment of fibrosis. ...
(Date:1/14/2014)... 14, 2014   Kinaxis ®, provider of RapidResponse ®, ... and operations planning ( S&OP ) service, is proud to ... which will be held at the Hilton San Diego Bayfront, ... customer Elisabeth Kaszas , Director of Supply Chain at ...
(Date:1/14/2014)... Kerr Corporation, a leading manufacturer of innovative dental ... about dual arch impressions on its dental blog. ... blog entry serves up a list of tips to help ... by Dr. David Little as he crafts a porcelain crown ...
Breaking Biology Technology:iLab Solutions Announces Michelle Detwiler as the New Director of Product Strategy 2RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 2RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 3Event Alert: Kinaxis Customer to Present at the Biomanufacturing Summit "Supply Chain: Improving Network Effectiveness" 2
... Ind. - Researchers have overcome a major obstacle in ... create a new class of electronics that would be ... nanotubes, which were discovered in the early 1990s, could ... well as ultra-thin "nanowires" for electronic circuits. The nanotubes ...
... Thomson Reuters announced today the publication of a ... interested in entering the Japanese generic drug market. ... market: opportunities and strategies for success," notes that a ... rapidly aging population and wide-ranging government initiatives to reduce ...
... Mass., Oct. 1 Idenix Pharmaceuticals, Inc. (Nasdaq: ... and development of drugs for the treatment of human ... the company,s lead hepatitis C development program, have been ... the American Association for the Study of Liver Diseases ...
Cached Biology Technology:Better control of carbon nanotube 'growth' promising for future electronics 2Better control of carbon nanotube 'growth' promising for future electronics 3Thomson Reuters Explores the Opportunities and Challenges of Entering the Japanese Generic Drug Market 2Thomson Reuters Explores the Opportunities and Challenges of Entering the Japanese Generic Drug Market 3Idenix Announces Data Presentations at the 60th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD) 2Idenix Announces Data Presentations at the 60th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD) 3
... BioChains human adult normal Mega Western ... proprietary technology. The Mega Western Protein Arrays ... lysates from documented tissue sources. A protein ... well electrophoresesed along with a Protein molecular ...
... applications not requiring confocal, the BD Pathway ... the Pathway 435. And, the Pathway 415 ... applications require it. High-performance, ... to use the laser autofocus, camera autofocus, ...
fully automated system for the processing of microarrays on microscope slides...
... containing Dermal Fibroblasts (rabbit) and media. Cryo-preserved ... 10% DMSO at passage 25 (approx), supplied ... cell culture is supplied as a long-term ... additional 6 months of continuous growth from ...
Biology Products: