Navigation Links
Differences in cell response could explain higher rates of hypertension in African-Americans
Date:8/29/2011

A key difference in the way that cells from African-Americans respond to inflammation could be an answer to why this group is disproportionately affected by hypertension, something that has eluded scientists for many years.

In a study published this month in Vascular Health and Risk Management, lead author Michael Brown and his team tested the effects of TNF-ά, a protein that causes inflammation when cells are damaged, on endothelial cells which line blood vessels in both African-Americans and Caucasians, to determine whether the inflammation affected the cells differently.

Among African-American cells, there was a nearly 90 percent increase in the production of endothelial microparticles, small vesicles that are released during inflammation. Individuals with hypertension have been shown to have higher levels of these microparticles in their bloodstream. Among Caucasians, there was only an eight percent increase in their production.

Brown said that although follow-up research needed to be done, "it appears that the endothelial cells in African Americans are more susceptible to the damaging effects of this inflammation." Brown is the director of the Hypertension Molecular and Applied Physiology Laboratory at Temple's College of Health Professions and Social Work.

Brown's research is unique in that it focuses on studying risk of hypertension at the cellular level; most research focuses on the clinical or physiological aspect. For more than 10 years, Brown has been trying to unlock the genetic reason behind the higher rates of hypertension and cardiovascular disease among African Americans.

Brown's research includes an exercise component, to test whether physical activity can reverse or prevent the damage done by hypertension at the cellular level.

"In our human study we have pre-hypertensive African-Americans, and we find this level of endothelial impairment. Knowing so early how inflammation ca
'/>"/>

Contact: Renee Cree
rencree@temple.edu
215-204-6522
Temple University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers note differences between people and animals on calorie restriction
2. Study sheds light on genetic differences that cause a childhood eye disease
3. Study identifies genetic variants giving rise to differences in metabolism
4. Genetic differences between yeasts greater than those between humans and chimpanzees
5. Differences in neighborhood food environment may contribute to disparities in obesity
6. Differences among exercisers and nonexercisers during pregnancy
7. Differences among exercisers and nonexercisers during pregnancy
8. Risk of vibration-induced vascular injuries linked to vibration frequency differences
9. Tiny differences in our genes help shed light on the big picture of human history
10. Geography and history shape genetic differences in humans
11. Scientists demonstrate importance of niche differences in biodiversity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... from shale rock has increased by more than ... not fully understand the industry,s effects on nature ... journal Frontiers in Ecology and the Environment ... outpace scientific examination, a team of eight conservation ... University, concluded that determining the environmental impact of ...
(Date:7/31/2014)... New research, supported by the National Science Foundation ... permafrost uniformly accelerates atmospheric warming, indicating instead that ... they emit into the atmosphere. , The ... Nature , focuses on thermokarst lakes, which occur ... fill with melted fresh water, converting what was ...
(Date:7/31/2014)... biomass burning burning forests to create agricultural ... agriculture and wildfires figures into both climate ... release of a new study by Stanford University ... the degree of that contribution had never been ... paper published July 30 in the Journal ...
Breaking Biology News(10 mins):'Fracking' in the dark: Biological fallout of shale-gas production still largely unknown 2'Fracking' in the dark: Biological fallout of shale-gas production still largely unknown 3Certain Arctic lakes store more greenhouse gases than they release 2Stanford professor finds that wildfires and other burns play bigger role in climate change 2Stanford professor finds that wildfires and other burns play bigger role in climate change 3Stanford professor finds that wildfires and other burns play bigger role in climate change 4
... the world, this week,s edition of Chemical & Engineering ... on the jobs situation for chemists -- whose work directly ... chemical industry in the United States alone a $674 billion ... American Chemical Society, the world,s largest scientific society. ...
... life scientists have identified a gene that slows the aging ... activated a gene called PGC-1, which increases the activity of ... growth and tell cells when to live and die. ... in different cells and tissues of the fly and asked ...
... tree outside Oak Ridge National Laboratory researcher Pratul Agarwal,s ... may ultimately lead to drugs with fewer side effects, ... breeze causes leaves, branches and ultimately the tree to ... of chemical processes that have a ripple effect necessary ...
Cached Biology News:UCLA biologists slow the aging process in fruit flies 2UCLA biologists slow the aging process in fruit flies 3ORNL fundamental discovery casts enzymes in new light 2
(Date:7/31/2014)... 2014 CollabRx, Inc. (NASDAQ: CLRX), a ... in oncology, today announced that it will hold an ... the Company's financial results for the first quarter of ... business in the current fiscal year. , The dial-in ... August 14, 2014, at 5 p.m. EDT (2 p.m. ...
(Date:7/31/2014)... Francisco, Calif. (PRWEB) July 31, 2014 ... newly diagnosed patients with an overview of the disease ... management of drug side effects, as well as updates ... “We’re grateful to Dr. Sandy Srinivas for organizing this ... survivor of kidney cancer. “Sandy and her colleagues have ...
(Date:7/31/2014)... 2014 “Rapid technological advances will ... U.S., increasing unemployment, depressing American consumer spending and ... a Catch 22—we need automated manufacturing if we ... jobs,” says economist and corporate relocation expert Dr. ... 10 Pro-Business States for 2014, co-published with the ...
(Date:7/31/2014)... Boston, MA (PRWEB) July 31, 2014 ... ) finds itself flush with innovative adult stem cell ... patents and has three additional patent applications ... Office. , The patented inventions address two of the ... and regenerative medicine. Adult stem cells are difficult ...
Breaking Biology Technology:CollabRx, Inc. Schedules First Quarter Fiscal Year 2015 Financial Conference Call and Business Update 2ITRA Global Affiliate’s Pollina Corporate Top 10 Pro-Business States Minimize the Impact of Automation on Middle Class and Unemployment 2ITRA Global Affiliate’s Pollina Corporate Top 10 Pro-Business States Minimize the Impact of Automation on Middle Class and Unemployment 3ITRA Global Affiliate’s Pollina Corporate Top 10 Pro-Business States Minimize the Impact of Automation on Middle Class and Unemployment 4The Adult Stem Cell Technology Center, LLC Launches A Marketing Campaign To License Adult Stem Cell Biotechnologies 2The Adult Stem Cell Technology Center, LLC Launches A Marketing Campaign To License Adult Stem Cell Biotechnologies 3
... Leading US Spine Centers Committed to the IEP,s ... 24 Magnifi Group, considered by,many industry observers ... within the medical device and pharmaceutical industries,announced here ... annual,meeting, its intent to organize and develop real-time ...
... Efforts to ... MENTOR, Ohio, Oct. 24 STERIS Corporation,(NYSE: STE ... its,VaproSure(TM) Room Sterilizer from several U.S. hospitals. The VaproSure,Room Sterilizer ... kind for the healthcare market. Since being introduced in,June of ...
... Cell Therapeutics,Inc. (CTI) (Nasdaq and MTAX: ... annual AACR-NCI-EORTC Symposium show its bis-platinate drug,candidates, ... currently,marketed platinum agents carboplatin, cisplatin and oxaliplatin. ... late 2008. "Bis-platinates represent a promising ...
Cached Biology Technology:Magnifi Group Demonstrates Industry's First Interactive Educational Program (IEP) for Spine Fellows 2Hospitals Adopt STERIS Advanced Room Sterilization Technology in the Fight Against 'Superbugs' 2Hospitals Adopt STERIS Advanced Room Sterilization Technology in the Fight Against 'Superbugs' 3Hospitals Adopt STERIS Advanced Room Sterilization Technology in the Fight Against 'Superbugs' 4Hospitals Adopt STERIS Advanced Room Sterilization Technology in the Fight Against 'Superbugs' 5Hospitals Adopt STERIS Advanced Room Sterilization Technology in the Fight Against 'Superbugs' 6First New Class of Platinum-Based Chemotherapy Drug Candidates in 30 Years Demonstrate Ability to Kill Tumors Resistant to Currently Marketed Platinum Drugs 2First New Class of Platinum-Based Chemotherapy Drug Candidates in 30 Years Demonstrate Ability to Kill Tumors Resistant to Currently Marketed Platinum Drugs 3
... you reduce the chance of error. Thats ... Developed using Beckman Coulters extensive experience in ... technology, the CEQ 8000 is a fully ... fills the capillary array with a patented ...
... monoclonal [6331] to Salmonella typhimurium The genus ... The genus is composed of Gram-negative bacilli that ... major antigens; the "H" or flagellar antigen (phase ... (part of the LPS moiety) and the "Vi" ...
... Antigen sequence: H-Ala-Cys-Asp-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asn-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Lys-Ala-Phe-NH ... For our corresponding peptide ... 2 5 I-labelled ... (human) (H-1470) and ([ ...
This free-standing laminar flow hood provides a horizontal flow of HEPA-filtered air to create a clean processing area. Air return slots along the front and side edges of the work area enhance system...
Biology Products: