Navigation Links
Differences between human twins at birth highlight importance of intrauterine environment
Date:7/15/2012

July 16, 2012 Your genes determine much about you, but environment can have a strong influence on your genes even before birth, with consequences that can last a lifetime. In a study published online in Genome Research (www.genome.org), researchers have for the first time shown that the environment experienced in the womb defines the newborn epigenetic profile, the chemical modifications to DNA we are born with, that could have implications for disease risk later in life.

Epigenetic tagging of genes by a chemical modification called DNA methylation is known to affect gene activity, playing a role in normal development, aging, and also in diseases such as diabetes, heart disease, and cancer. Studies conducted in animals have shown that the environment shapes the epigenetic profile across the genome, called the epigenome, particularly in the womb. An understanding of how the intrauterine environment molds the human epigenome could provide critical information about disease risk to help manage health throughout life.

Twin pairs, both monozygotic (identical) and dizygotic (fraternal), are ideal for epigenetic study because they share the same mother but have their own umbilical cord and amniotic sac, and in the case of identical twins, also share the same genetic make-up. Previous studies have shown that methylation can vary significantly at a single gene across multiple tissues of identical twins, but it is important to know what the DNA methylation landscape looks like across the genome.

In this report, an international team of researchers has for the first time analyzed genome-scale DNA methylation profiles of umbilical cord tissue, cord blood, and placenta of newborn identical and fraternal twin pairs to estimate how genes, the shared environment that their mother provides and the potentially different intrauterine environments experienced by each twin contribute to the e
'/>"/>

Contact: Peggy Calicchia
calicchi@cshl.edu
516-422-4012
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1 2

Related biology news :

1. Scientists find differences in naked mole rats protein disposers
2. Biologists turn back the clock to understand evolution of sex differences
3. Knee injuries in women linked to motion, nervous system differences
4. Autism risk gene linked to differences in brain structure
5. Highlighting molecular clues to the link between childhood maltreatment and later suicide
6. How sweet it is: Tomato researchers discover link between ripening, color and taste
7. Study provides first evidence of coevolution between invasive, native species
8. Link between vitamin C and twins can increase seed production in crops
9. IU role in Human Microbiome Project exposes battle history between bacteria, viruses in human body
10. Biosignatures distinguish between tuberculosis and sarcoidosis
11. Geographic information systems demonstrate links between health and location
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... members to reduce aggression and gain access to scarce ... activities shows a certain pattern across the day. The ... Biology Letters . , Grooming between individuals in a ... To be groomed has hygienic benefits and is stress ... provide access to infants, mating opportunities and high quality ...
(Date:7/11/2014)... of mesenchymal stem cells can stimulate neurogenesis in the ... disease (AD) and improve tissue and function injury under ... on the therapeutic effect of adipose-derived stem cells (ADSCs) ... on oxidative injury and neurogenesis in the brain of ... of Life Sciences, Tsinghua University, China transplanted ADSCs into ...
(Date:7/11/2014)... let nerve cells send out electrical signals, Johns Hopkins ... that may offer a new way to protect crops ... way. , Their findingthat naturally occurring insect toxins ... a closely related onesuggests that insecticides can be designed ... bees. A summary of the research, led by Frank ...
Breaking Biology News(10 mins):Baboons groom early in the day to get benefits later 2Potent spider toxin 'electrocutes' German, not American, cockroaches 2Potent spider toxin 'electrocutes' German, not American, cockroaches 3
... could take greater strides toward crop improvement if there ... the mechanisms that allow plants to adapt to their ... In a perspective for the journal Science , ... Ivan Baxter, a research computational biologist for the U.S. ...
... a kingdom was lost. A similar, seemingly innocuous changethe evolution ... on the carbon cycle, bringing an end to the 60-million ... Coal generated nearly half of the roughly four trillion kilowatt-hours ... to the U.S. Energy Information Administration. This fuel is actually ...
... perfect, red tomatoes from the store just can,t match the ... Institute for Plant Research at Cornell University, USDA and the ... contributes to the level of sugar, carbohydrates and carotenoids in ... Nguyen, a Cornell graduate student in plant breeding working at ...
Cached Biology News:Adoption of advanced techniques could propel crop improvement 2How an ancestral fungus may have influenced coal formation 2How an ancestral fungus may have influenced coal formation 3How an ancestral fungus may have influenced coal formation 4How an ancestral fungus may have influenced coal formation 5How sweet it is: Tomato researchers discover link between ripening, color and taste 2
(Date:7/11/2014)... BEACH, Fla. , July 11, 2014 /PRNewswire-iReach/ -- ... of high-quality peptides that are used solely in scientific ... honor two successful years in business, Maxim Peptide, which ... has just launched a new and updated website that ... research blog section has been updated with fascinating articles ...
(Date:7/11/2014)... , Not for release, publication or distribution (in whole ... to do so would constitute a violation of the relevant ... the "Company") (LSE: SHP, NASDAQ: SHPG ) notes ... a meeting with representatives of AbbVie. This statement ... approval of AbbVie. A further update will be ...
(Date:7/11/2014)... 2014 Research and Markets  has announced ... - Global Industry Analysis, Size, Share, Growth, Trends and ... http://photos.prnewswire.com/prnh/20130307/600769 Transfection ... DNA or RNA) into cells. This technology helps the ... and protein metabolism by affecting the nuclear genes. The ...
(Date:7/11/2014)... (PRWEB) July 11, 2014 BCC Research ... DIGITAL POLYMERASE CHAIN REACTION (PCR) TECHNOLOGY: GLOBAL MARKETS ... (PCR) technology reached nearly $140 billion in 2013. This ... registering a five-year compound annual growth rate (CAGR) of ... number of interesting and exciting possibilities within the broader ...
Breaking Biology Technology:Maxim Peptide Celebrates Second Anniversary Online with an Updated Website and Special Deals Section 2Shire plc - Statement re: Media Speculation 2International Transfection Technology Market - Industry Analysis, Size, Share, Growth, Trends and Forecast to 2019 2Global Market for Digital Polymerase Chain Reaction Technology to Reach $490 Billion by 2018; Equipment Sector Accounts for the Fastest Growing Segment With 33% CAGR 2Global Market for Digital Polymerase Chain Reaction Technology to Reach $490 Billion by 2018; Equipment Sector Accounts for the Fastest Growing Segment With 33% CAGR 3
... PURE Bioscience picks Microsoft technology over competitors for its ... use, scalability and manufacturing capabilities., ... that PURE Bioscience has selected Microsoft Dynamics AX 4.0,to ... the,company,s compliance with the Sarbanes-Oxley Act and with the ...
... Medical,Systems (NYSE: VAR ) announced today that it will report results ... on,Wednesday, April 23, 2008. The news release will be followed by a,teleconference ... Varian Medical Systems quarterly results can be accessed on April 23,2008 via:, ... via phone at 650-424-5834 or via ...
... Biotech Ltd. (Amex:,SVA), a leading provider of vaccines in ... on Monday, March 31, 2008 at 9:00 a.m. ET ... 31, 2007 financial,results and provide an update on recent ... dial 1-877-407-4018 (USA) or,1-201- 689-8471 (international). A replay of ...
Cached Biology Technology:Bioscience Company Chooses Microsoft Dynamics AX to Improve Support for Compliance With Industry Rules 2Bioscience Company Chooses Microsoft Dynamics AX to Improve Support for Compliance With Industry Rules 3Bioscience Company Chooses Microsoft Dynamics AX to Improve Support for Compliance With Industry Rules 4Bioscience Company Chooses Microsoft Dynamics AX to Improve Support for Compliance With Industry Rules 5Varian Medical Systems Schedules Second Quarter FY2008 News Release and Conference Call 2Varian Medical Systems Schedules Second Quarter FY2008 News Release and Conference Call 3Sinovac to Host Conference Call to Report Fourth Quarter and Full Year 2007 Financial Results 2
... assay kit provides complete components including ... convenient detection of DNA fragmentation in ... incorporation of BrdU in the procedure ... digoxigenylated methods. Results can be analyzed ...
... IonQuest will provide great value plus ... detector has very high sensitivities and ... to the standard conductivity detector, the IonQuest ... as electrochemical, refractive index, UV/Visible, WaveQuest UV/Visible ...
... the space and time dimensions of a streak ... microscope to open new horizons in biological imaging. ... excitation, the decay of a fluorescence emission can ... measured. Subtle changes in the local environment ...
... SDS and Non-ionic Detergent Removal ... detergent , Very selective, virtually no cross-reactivity ... centrifuge and discard pellet , Economical ... chromatography , Detergents can often interfere with ...
Biology Products: