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Dietary treatment shows potential in a mouse model of Alzheimer's disease
Date:1/24/2014

mice performed significantly poorer than wild-type mice in the Morris swim navigation task, which measures long-term spatial memory. Among transgenic mice on the experimental diets, the mice on the Fortasyn diet performed equally well as the wild-type mice, whereas other dietary treatments showed no improvement. However, all test diets reversed the memory deficit of the APP/PS1 mice in the odour recognition task. The levels of accumulated amyloid-β protein in the brain were examined at the end of the study. A significant reduction in the amyloid-β levels was observed in the plant sterol group while other experimental diets showed no effect. However, why was a substantial reduction in brain amyloid-β levels not accompanied by a positive memory effect in the spatial task in the plant sterol group? One explanation is that the plant sterol diet increased formation of reactive oxygen species in the hippocampus, whereas the Fortasyn diet, which yielded the best results in the spatial memory task, tended to have an opposite effect.

The results indicate that even slight changes in the composition of the diet may, under a sufficiently long period of time and at an early stage of the disease process, lead to significant changes in brain metabolism and improved memory performance. On the other hand, the mere brain amyloidosis in Alzheimer's disease involves several mechanisms and it is unlikely that a single cocktail of nutrients will provide an optimal outcome. According to the researchers, the results definitely encourage further development of dietary treatments for Alzheimer's disease.

The now studied Fortasyn supplement is found in the medical nutrition formulation Souvenaid that just was introduced in Finland. In the light of the present results, the product can be warmly recommended for the treatment of mice suffering from mild cognitive impairment (pre-Alzheimer's), but will it work as efficiently in humans, too? We will probably get
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Contact: Heikki Tanila
heikki.tanila@uef.fi
358-403-552-084
University of Eastern Finland
Source:Eurekalert

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