Navigation Links
Dietary calcium could possibly prevent the spread of breast cancer to bone

PHILADELPHIA A strong skeleton is less likely to be penetrated by metastasizing cancer cells, so a fortified glass of milk might be the way to block cancers spread, according to researchers at the ANZAC Research Institute in Concord, Australia. Using a mouse model of breast cancer metastasis, the researchers found that a calcium deficiency may increase the tendency of advanced breast cancer to target bone. Dietary calcium, they reason, might help prevent the spread of breast cancer to bone and serve as an adjuvant treatment during therapy.

Their findings are presented in the Oct. 1 issue of Cancer Research, a journal of the American Association for Cancer Research.

According to the researchers, about 70 percent of patients who develop advanced breast cancer will have secondary tumors in the bone. The spread of cancer to bones leads to cellular processes that physically break down existing bone, leading to further pain and illness. In fact, the breakdown of bone and subsequent bone re-growth forms what senior author Colin R. Dunstan, Ph.D., terms a vicious cycle that turns bone into an environment conducive to cancer growth.

To better understand the role of bone turnover in the spread of cancer, Dunstan and his team compared the effects of a low- and high-calcium diet in mice. They found that dietary calcium deficiency independent of the chemical factors that control turnover was related to a significantly higher increase in cancer cell proliferation and the total proportion of bone that had been penetrated.

These results could have implications for patients with breast cancer bone metastases or who are at high risk for developing metastatic disease, Dunstan said. Many older women in our community are known to be calcium deficient due to low calcium dietary intake or due to vitamin D deficiency. These women could be at increased risk for the devastating effects of bone metastases.

According to Dunstan, his results call for further, directed clinical trials to investigate how calcium and vitamin D status influence progression to metastatic disease, and to determine if corrections of calcium and vitamin D deficiencies are important in breast cancer patients.


Contact: Greg Lester
American Association for Cancer Research

Related biology news :

1. Eat less, weigh more? Enzyme makes lean mice susceptible to dietary fat
2. ASU research shows connection between testosterone, dietary antioxidants and bird coloration
3. Major WHO study concludes calcium supplements can reduce complications during pregnancy
4. Protein discovery could unlock the secret to better TB treatment
5. Tiny particles could solve billion-dollar problem
6. Novel Therapy Tested in Mice Could Chase Away Cat Allergies
7. Spider Venom Could Yield Eco-Friendly Insecticides
8. First atlas of key brain genes could speed research on cancer, neurological diseases
9. Discovery of key proteins shape could lead to improved bacterial pneumonia vaccine
10. A comprehensive response to HIV could prevent 10 million AIDS deaths in Africa by 2020
11. New Breast Cancer Test Could Save Lives
Post Your Comments:
(Date:6/22/2016)... LOS ANGELES , June 22, 2016 ... of identity management and verification solutions, has ... cutting edge software solutions for Visitor Management, ... ® provides products that add functional ... The partnership provides corporations and venues with ...
(Date:6/16/2016)... , June 16, 2016 ... size is expected to reach USD 1.83 billion ... Grand View Research, Inc. Technological proliferation and increasing ... applications are expected to drive the market growth. ... , The development of advanced multimodal ...
(Date:6/7/2016)... , June 7, 2016  Syngrafii Inc. and ... business relationship that includes integrating Syngrafii,s patented LongPen™ ... project. This collaboration will result in greater convenience ... credit union, while maintaining existing document workflow and ... ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... , June 27, 2016 /PRNewswire/ - BIOREM Inc. (TSX-V: BRM) ... advised by its major shareholders, Clean Technology Fund I, ... United States based venture capital funds which ... Biorem (on a fully diluted, as converted basis), that ... of their entire equity holdings in Biorem to TUS ...
(Date:6/27/2016)... ... June 27, 2016 , ... Parallel 6 , the leading ... the Clinical Reach Virtual Patient Encounter CONSULT module which enables both audio ... and clinical trial team. , Using the CONSULT module, patients and physicians can schedule ...
(Date:6/27/2016)... PHILADELPHIA , June 27, 2016  Liquid ... today announced the funding of a Sponsored Research ... study circulating tumor cells (CTCs) from cancer patients.  ... changes in CTC levels correlate with clinical outcomes ... therapies. These data will then be employed to ...
(Date:6/24/2016)... , June 24, 2016 Epic Sciences ... detects cancers susceptible to PARP inhibitors by targeting ... cells (CTCs). The new test has already been ... in multiple cancer types. Over 230 ... damage response pathways, including PARP, ATM, ATR, DNA-PK ...
Breaking Biology Technology: