Navigation Links
Dietary amino acids improve sleep problems in mice with traumatic brain injury
Date:12/11/2013

PORTLAND, Ore. Scientists have discovered how to fix sleep disturbances in mice with traumatic brain injuries a discovery that could lead to help for hundreds of thousands of people who have long-term and debilitating sleep and wakefulness issues after they suffer concussions.

What scientists found helpful was giving the mice something all humans produce from foods in their normal diets something called branched chain amino acids.

"If further research confirms what this study suggests, we could develop a dietary supplement of these amino acids that could be a viable therapy to help people after a concussion," said Miranda Lim, M.D., Ph.D., a neurologist and sleep medicine specialist at the Portland VA Medical Center and an assistant professor of pulmonary and critical care medicine, neurology and behavioral neuroscience at Oregon Health & Science University. Lim is the first author of the study, published online today in Science Translational Medicine.

Lim performed this research during her sleep medicine fellowship at the University of Pennsylvania. Senior authors on the study are Akiva S. Cohen, Ph.D., a neuroscientist at The Children's Hospital of Philadelphia and Allan I. Pack, M.D., Ph.D., director of the Center for Sleep and Circadian Neurobiology in the Perelman School of Medicine at the University of Pennsylvania.

Nearly 2 million people a year in the United States suffer a traumatic brain injury, including concussion, which is considered a mild traumatic brain injury. Sleep disturbances are common in those with TBI; some studies show up to 72 percent of TBI patients including those who've suffered concussions have sleep problems.

Sleep problems impair attention and memory formation in TBI patients, who have a higher rate of functional disability and a higher cost of rehabilitation.

"Sleep disturbances, such as excessive daytime sleepiness and nighttime insomnia, disrupt quality of life and can delay cognitive recovery in patients with TBI," Lim said. Although physicians can relieve the dangerous swelling that occurs after a severe TBI, there are no existing treatments to address the underlying brain damage associated with problems such as impaired memory, learning and sleep patterns.

In their study, the scientists compared mice with mild TBI to uninjured mice. They found that injured mice were much less able to stay awake for sustained periods of time. The scientists also found that the orexin neurons in the brains of injured mice were much less active than the same neurons in uninjured mice. Orexin neurons help to maintain wakefulness, in mice and in humans. Human studies have shown decreased orexin levels in the spinal fluid of people who have suffered a traumatic brain injury.

Based on prior research, the scientists gave the injured mice a dietary therapy of branched chain amino acids which humans get most often through foods high in protein, including red meat, poultry and eggs. Branched chain amino acids are the building blocks of neurotransmitters, the chemicals released by neurons in the brain. Like the oil in a car engine, branched chain amino acids keep neurons running smoothly and boost neuron excitability. The branched chain amino acids restored the orexin neurons in the injured mice to a normal activity level, and improved wakefulness.

"These results in an animal model provide a proof-of-principle for investigating this dietary intervention as a treatment for TBI patients," said Cohen. "If a dietary supplement can improve sleeping and waking patterns as well as cognitive problems, it could help brain-injured patients regain crucial functions."

The scientists note that human patients with a variety of disorders have been treated with branched chain amino acid therapy for up to two years without adverse effects, so with further study it may prove to be a viable therapy for sleep problems in TBI patients. Cohen cautioned, however, that current evidence does not support TBI patients medicating themselves with commercially available amino acid supplements.


'/>"/>

Contact: Todd Murphy
murphyt@ohsu.edu
503-494-8231
Oregon Health & Science University
Source:Eurekalert

Related biology news :

1. Enrollment in SNAP does not substantially improve food security or dietary quality
2. Studies support population-based efforts to lower excessive dietary sodium intakes
3. Dietary flexibility may have helped some large predators survive after last ice age
4. National survey highlights perceived importance of dietary protein to prevent weight gain
5. Canadians support interventions to reduce dietary salt
6. International study: Excess dietary salt may drive the development of autoimmune diseases
7. Dietary shifts driving up phosphorus use
8. New health-economic model shows benefits of boosting dietary calcium intake
9. Research provides new insights into dogs natural feeding behavior and finds they target a daily dietary intake that is high in fat
10. Neuroprotective dietary supplements for chronic spinal cord injury
11. Zebrafish research shows how dietary fat regulates cholesterol absorption
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/2/2016)... YORK , June 2, 2016   The Weather ... is announcing Watson Ads, an industry-first capability in which consumers ... by being able to ask questions via voice or text ... Marketers have long sought ... the consumer, that can be personal, relevant and valuable; and ...
(Date:6/1/2016)... June 1, 2016 Favorable Government ... Administration and Criminal Identification to Boost Global Biometrics System ... released TechSci Research report, " Global Biometrics Market ... Forecast and Opportunities, 2011 - 2021", the global biometrics ... 2021, on account of growing security concerns across various ...
(Date:5/20/2016)... May 20, 2016  VoiceIt is excited to ... VoicePass. By working together, VoiceIt and ... VoiceIt and VoicePass take slightly different approaches to ... both security and usability. ... this new partnership. "This marketing and ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... , ... June 23, 2016 , ... ... pleased to announce the launch of their brand, UP4™ Probiotics, into Target stores ... 35 years, is proud to add Target to its list of well-respected retailers. ...
(Date:6/23/2016)... 23, 2016 A person commits a crime, and ... to track the criminal down. An outbreak of ... Drug Administration (FDA) uses DNA evidence to track down the ... Sound far-fetched? It,s not. The FDA has increasingly used a ... of foodborne illnesses. Put as simply as possible, whole genome ...
(Date:6/23/2016)... MONICA, Calif. , June 23, 2016  The Prostate Cancer Foundation ... pioneer increasingly precise treatments and faster cures for prostate cancer. Members of the ... institutions across 15 countries. Read More About the Class ... ... ...
(Date:6/23/2016)... ... 2016 , ... Supplyframe, the Industry Network for electronics hardware ... . Located in Pasadena, Calif., the Design Lab’s mission is to bring together ... built and brought to market. , The Design Lab is Supplyframe’s physical representation ...
Breaking Biology Technology: