Navigation Links
Diet could combat adverse side-effects of quinine
Date:9/11/2012

Scientists at The University of Nottingham say adverse side-effects caused by the anti-parasitic drug quinine in the treatment of malaria could be controlled by what we eat.

The research, carried out by Nottingham scientists on the University's campuses in the UK and Malaysia, indicates that natural variation in our levels of the amino acid, tryptophan, has a marked bearing on how we respond to quinine treatment. It appears that the lower our levels of tryptophan the more likely it is that we would suffer side-effects. And because tryptophan is an essential amino acid the body cannot produce it we get it from the food we eat.

Discovered back in the 1600s, quinine is still used for anti-malaria treatment. However, it is associated with a long list of side effects ranging from sickness and headaches to blindness, deafness and in rare cases death. This latest study, published in the Journal of Antimicrobial Chemotherapy, could offer a cheap and simple way of combating our adverse reaction to quinine treatment and improving the performance of this important drug.

The study, funded by The University of Nottingham's doctoral award scheme, was led by Dr Simon Avery and Dr Kang-Nee Ting from the Schools of Biology in the UK and Biomedical Sciences in Malaysia, in collaboration with Professor Richard Pleass now at the University of Liverpool.

Reinforcing previous research

These findings reinforce a discovery they made three years ago.

Using a yeast model, which is a relatively close evolutionary neighbour of the human, they showed that quinine can block take-up of tryptophan, causing quinine toxicity in cells. This research, published in 2009, gave the scientific community a new insight into the way quinine behaves and led Dr Avery and his team to believe that a quinine/tryptophan combination therapy might allow the use of higher quinine dosages to improve the effectiveness of the drug and reduce the
'/>"/>

Contact: Lindsay Brooke
lindsay.brooke@nottingham.ac.uk
44-011-595-15751
University of Nottingham
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Heart-powered pacemaker could one day eliminate battery-replacement surgery
2. New test could help track down and prosecute terrorists
3. New antibiotic could make food safer and cows healthier
4. BPA could affect reproductive capabilities, cause infection of the uterus
5. Key to immune system disease could lie inside the cheek
6. New analysis of premature infants heartbeats, breathing could be cues for leaving NICU
7. Tiny electrical sensors could signal faster MRSA diagnosis
8. Corals could survive a more acidic ocean
9. Early warning system for seizures could cut false alarms
10. Rapid method of assembling new gene-editing tool could revolutionize genetic research
11. 800-year-old farmers could teach us how to protect the Amazon
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... 2014 Winners of The Economist,s prestigious Innovation ... to take place at the JW Marriott Hong Kong on Friday, ... will share their experiences and the lessons those hold for others. ... innovation over the past decade, will be presented at a ceremony ... summit. It will be the first time the ceremony has come ...
(Date:9/29/2014)... DC September 29, 2014 -- Plants have ... bacteria help the pants extract nutrients and defend ... pathogens from contaminating fruits and vegetables. Now, scientist ... bacteria inside of seeds; thus ensuring that sprouting ... from the University of Notre Dame, presented their ...
(Date:9/29/2014)... school? According to a new Food and Brand Lab ... can increase participation in the National School Lunch Program ... vegetables by 16%! , Chefs Move to Schools (CMTS), ... chefs with schools in order to provide nutrition instruction ... service workers. , A CMTS event was held in ...
Breaking Biology News(10 mins):Hear from The Economist's 2014 Innovation Award Winners at Innovation Summit on October 10th in Hong Kong 2Hear from The Economist's 2014 Innovation Award Winners at Innovation Summit on October 10th in Hong Kong 3Hear from The Economist's 2014 Innovation Award Winners at Innovation Summit on October 10th in Hong Kong 4Hear from The Economist's 2014 Innovation Award Winners at Innovation Summit on October 10th in Hong Kong 5Hear from The Economist's 2014 Innovation Award Winners at Innovation Summit on October 10th in Hong Kong 6Hear from The Economist's 2014 Innovation Award Winners at Innovation Summit on October 10th in Hong Kong 7Plants prepackage beneficial microbes in their seeds 2Chefs move to schools can increase school meal participation and vegetable intake among students 2
... may hold the answer to making solar cells a ... of Engineering Physics at McMaster University, Cleanfield Energy and ... partnership to pursue the commercialization of nanowire technology in ... of nanowire technology developed at McMaster is able to ...
... 2008) Determined to revive the grossly depleted soils ... of poverty and hunger, the Alliance for a Green ... five-year program to restore the fertility of Africas soils. ... into soils where rapid nutrient loss is sapping the ...
... at the Picower Institute for Learning and Memory at MIT ... they have created a way to see, for the first ... circuit in a living animal. This revolutionary method allowed ... to see how bypassing a major memory-forming circuit in the ...
Cached Biology News:Nanowires hold promise for more affordable solar cells 2Alliance for a Green Revolution in Africa commits 180M to revive farmers' depleted soils 2Alliance for a Green Revolution in Africa commits 180M to revive farmers' depleted soils 3Alliance for a Green Revolution in Africa commits 180M to revive farmers' depleted soils 4New MIT tool probes brain circuits 2
(Date:9/30/2014)... , Sept. 30, 2014 Nematicide ... kill nematodes. Nematodes are microscopic parasitic roundworms, found ... and inside other plants and animals. Nematicides have ... or other properties promoting migration through the soil. ... than 1,000 plant-parasitic nematodes. With more than 10,000 ...
(Date:9/30/2014)... Md. , Sept. 30, 2014  RegeneRx ... today announced that it has received a Canadian ... by Actin-Sequestering Peptides.  This patent includes claims using ... numerous other actin-sequestering peptides for these purposes.  The ... About RegeneRx Biopharmaceuticals, Inc. ( www.regenerx.com ) ...
(Date:9/30/2014)... (PRWEB) September 30, 2014 OriginOil Inc. ... high-speed, chemical-free process to clean up large quantities of ... CEO Riggs Eckelberry reported on the launch of the ... a site provided by partner STW Resources . ... 1000 barrels per day (bpd) and achieved a 99.8% ...
(Date:9/30/2014)... Boston, MA (PRWEB) September 30, 2014 ... Core Facility Management Benchmarking study which focuses on ... the common challenges core managers face today. , In ... were revealed. One of note is the year-over-year decrease ... contributions. Core managers appear to be feeling the constraints ...
Breaking Biology Technology:Nematicides Market by Types (Fumigants, Organophosphates, Carbamate and Bio-Nematicides), Applications (Agrochemicals, Industrial, and Others), and Geography (North America, Europe, Asia-Pacific & ROW) - Global Trends & Forecasts to 2019 2RegeneRx Receives Canadian Patent for Inhibition or Reversal of Skin Aging 2OriginOil, Inc. Report to Shareholders: Blue Gold in West Texas 2iLab Solutions Announces the Results of the 2014 Core Facility Benchmarking Study 2iLab Solutions Announces the Results of the 2014 Core Facility Benchmarking Study 3
... Fiserv Inc. has unveiled a program of healthcare ... processing and health-plan administration. , ,Spurred on ... banking is a set of services which includes ... payments between parties in healthcare transactions. , ...
... The increased use of clinical technologies in healthcare does ... for care decisions, particularly when technology vendors include strong ... developers market their products more directly to consumers, they ... attendees of the recent Digital Healthcare Conference ...
... events, is coming to Milwaukee again on June 22 and 23 ... both global and Wisconsin-area technology companies. , ,The conference will feature ... Networks , Agilent , EqualLogic , Inacom , ... Runner Business Class and other companies. , ,Attendees will have ...
Cached Biology Technology:Liability issues not seen as roadblock to healthcare technology advancements 2Liability issues not seen as roadblock to healthcare technology advancements 3
PKC Sampler Kit 10 mu g each...
Golgi Sampler Kit 10g each...
Umbilical cord blood eosinophils, For immunohistochemistry (IHC)...
Monocyte-derived dendritic cells, For immunohistochemistry (IHC) Cell Chip with Human Umbilical Cord Blood Dendritic Cells...
Biology Products: