Navigation Links
Diet and lifestyle critical to recovery, says study
Date:1/17/2008

Diet and lifestyle may play a much more significant role in a persons ability to respond favourably to certain drugs, including some cancer therapies, than previously understood, say scientists.

Writing in Nature Genetics, University of Manchester researchers have shown how the nutrients in the environment are critical to the fitness of cells that carry genetic mutations caused by diseases.

The findings for the first time provide a scientific insight into why some people might respond better to certain medications than others and form the foundations for more individualised drug therapy in the future.

The team used bakers yeast a model organism studied by biologists to reveal molecular processes in higher organisms to explore the relationship between environment and genetic background.

The large-scale study involved removing one of the two copies of all yeast genes similar to removing one parents set of genes in a human and analysing the resulting fitness under different dietary restrictions.

If the gene targeted is quantitatively important, you would normally expect the yeast to show a reduction in fitness, said Dr Daniela Delneri, who carried out the research in the Universitys Faculty of Life Sciences.

But what we found was that in certain environmental conditions, removing one copy of certain genes actually produced the opposite effect and surprisingly the yeast cells grew more quickly and were healthier.

The team further established that this effect was mainly occurring in genes involved in the proteasome the quality-control system within the cell that degrades unwanted proteins.

The proteasome is important as it maintains the equilibrium of the cell, said Dr Delneri. When this equilibrium is lost it can result in a number of diseases, including cancer, diabetes, Huntingdons, Alzheimers and Parkinsons.

For example, in rapidly-growing cancerous cells the high proteasome ac
'/>"/>

Contact: Aeron Haworth
aeron.haworth@manchester.ac.uk
44-161-275-8383
University of Manchester
Source:Eurekalert

Page: 1 2

Related biology news :

1. SAGEs American Journal of Lifestyle Medicine looks at the health benefit of oats
2. Critically endangered Amur leopard captured
3. First-ever study: lack of critical lubricant causes wear in joints
4. Rutgers scientists research reveals critical knowledge about the nervous system
5. Critically endangered porpoise is focus of new research report
6. Childhood obesity indicates greater risk of school absenteeism, Penn study reveals
7. A study by the MUHC and McGill University opens a new door to understanding cancer
8. Study begins to reveal clues to the cause and progression of sepsis
9. Clones on task serve greater good, evolutionary study shows
10. New study warns limited carbon market puts 20 percent of tropical forest at risk
11. New study examines how rearing environment can alter navigation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/13/2015)... 2015 According to a ... Market Forecast & Opportunities, 2020", the global biometrics market ... 14% till 2020. The biometrics market is garnering ... and review of biometric management systems. The constant ... with greater efficiency, are resulting in increasing installation ...
(Date:4/9/2015)... , April 9, 2015 Synaptics Inc. (NASDAQ: ... announced today that it will report financial results for ... 23, 2015, after the close of market. The company ... investors at 2:00 p.m. PT (5:00 p.m. ET), during ... To participate on the live call, analysts and investors ...
(Date:4/2/2015)... In the current eight ... the strongest competitors, showing outstanding performance in recognition ... is capable of a throughput of 5.000.000 fingerprints ... be ten times faster than most competitors and ...      (Photo: http://photos.prnewswire.com/prnh/20150402/738673-a ) , ...
Breaking Biology News(10 mins):Global Biometrics Market to Cross US$ 21 Billion by 2020: TechSci Research 2Synaptics to Report Third Quarter Results on April 23 2DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 2DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 3
... so quickly identifying them can be crucial to stopping ... take hours and days. But not for much longer. ... and electrical engineering at the University of Tennessee, Knoxville, ... Fisheries at the UT Institute of Agriculture Center for ...
... -- Earlier today, nine university presidents representing the ... Vincent C. Gray at American University,s LEED-Gold certified ... District of Columbia Mayor,s College and University Sustainability ... the first of its kind in the nation. ...
... a child finds a fat caterpillar, puts it in a jar ... to find the caterpillar has disappeared and an elegant but apparently ... jar has been forgotten, soft beating against its glass walls calls ... butterfly or dusky moth with fringed antennae. These transformations are ...
Cached Biology News:University of Tennessee researchers invent device to rapidly detect infectious disease 2Mayor Gray, University presidents pledge to make DC the 'Greenest College Town in America' 2Mayor Gray, University presidents pledge to make DC the 'Greenest College Town in America' 3Mayor Gray, University presidents pledge to make DC the 'Greenest College Town in America' 4Scientists learn how insects 'remodel' their bodies between life stages 2Scientists learn how insects 'remodel' their bodies between life stages 3Scientists learn how insects 'remodel' their bodies between life stages 4
(Date:5/26/2015)... -- Alere Inc. (NYSE: ALR ) (the "Company") announced today ... its Quarterly Report on Form 10-Q for the three months ... a notice from the New York Stock Exchange (the "NYSE") ... continued listing requirements under the timely filing criteria established in ... The reason for the delay relates to Company,s need ...
(Date:5/26/2015)... 26, 2015   PDI , a leader ... that Oakwood Healthcare in Dearborn, Mich. ... entry in Delivering the Difference ... excellence in building collaborative relationships between infection prevention ... facilities.  Oakwood Healthcare,s infection preventionist, ...
(Date:5/26/2015)... , 26. mája 2015 Kevin ... svojej rodiny prezidentom Barackovi Obamovi a Billovi Clintonovi ... so stratou Dr. Rongxiang Xu , otca ... Dr. Xu bol pionier, inovátor, ... jeho odhodlanie v oblasti vedy a príkladné vedenie ...
(Date:5/26/2015)... Fluorinov Pharma (Fluorinov), a FACIT portfolio company, today announced ... its Board of Directors.  His appointment strengthens Fluorinov,s leadership ... accelerates its clinical development activities.  "On ... to welcome Luke to the Board of Directors.  Luke ... strength and success of multiple organizations," said Malik ...
Breaking Biology Technology:PDI Announces Winner in Delivering the Difference Contest 2PDI Announces Winner in Delivering the Difference Contest 3Dr. Rongxiang Xu, O legende 2Luke M. Beshar Appointed to Fluorinov Pharma Board of Directors 2Luke M. Beshar Appointed to Fluorinov Pharma Board of Directors 3
... DETROIT, Nov. 3 On October 31, 2008, Caraco,Pharmaceutical ... from the FDA. The letter was issued as a ... manufacturing facility in Detroit,Michigan which was initiated in May ... in June 2008 following this inspection. The Company,had responded ...
... NLTX ), announced today that Peter Strumph, Chief ... -- Rodman & Renshaw 10th Annual Healthcare Conference ... Monday, November 10, 2008 at The Palace Hotel in,New ... Healthcare Conference at 9:00 a.m.,ET on Wednesday, November 19, ...
... its lead sponsorship of the International Genetically ... annually by the Massachusetts Institute of Technology ... 84 undergraduate teams representing more than 1,000 ... Latin America, and the U.S. to design ...
Cached Biology Technology:Caraco Pharmaceutical Laboratories, Ltd. Receives FDA Warning Letter 2Nile Therapeutics to Present at Two Upcoming Investor Conferences 2 The MathWorks Sponsors iGEM Competition for Synthetic Biology at MIT : MATLAB and SimBiology Help Accelerate Design of Synthetic Biological Systems 2 The MathWorks Sponsors iGEM Competition for Synthetic Biology at MIT : MATLAB and SimBiology Help Accelerate Design of Synthetic Biological Systems 3
Sprague-Dawley rats, 7-8 weeks old, mixed gender; tissue is collected fresh, frozen on dry ice within minutes of sacrifice and stored at -20C; individual tissue weight approx. 0.05 gram....
CMRL Medium-1066 (1X) liquid...
Rabbit anti-T-box 6...
TNF-R2 (L-20)...
Biology Products: