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Did an evolutionary arms race cause lupus? Biologist Harmit Malik receives grant to try and find out
Date:2/17/2012

ic conflict, Malik sees battles raging within a cell's nucleus as genes jockey for evolutionary dominance. These clashes can have a long-term impact on organisms, as they sometimes alter the function of essential genes. Malik uses biochemistry and genomics to study the causes and consequences of these genetic conflicts in yeast, fruit flies and other model organisms. His work has offered novel explanations in two disciplines: host-pathogen interactions and the evolution of structural DNA elements (centromeres) that are critical for proper cell division.

Malik was among 12 researchers to receive Lupus Research Institute grants totaling $3.6 million to accelerate discovery in lupus by supporting original, highly promising ideas from some of the country's most creative scientists.

"What distinguishes the Lupus Research Institute is our insistence on funding only novel ideas rather than furthering established concepts," said Margaret Dowd, LRI president and CEO. "Our success in delivering pivotal discoveries proves that openness to inventive science works. As one advisor eloquently noted, 'great science cannot be managed; it must be imagined.'"
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Contact: Kristen Woodward
kwoodwar@fhcrc.org
206-667-5095
Fred Hutchinson Cancer Research Center
Source:Eurekalert

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