Navigation Links
Did an evolutionary arms race cause lupus? Biologist Harmit Malik receives grant to try and find out
Date:2/17/2012

SEATTLE Evolutionary biologist Harmit Singh Malik, Ph.D., of Fred Hutchinson Cancer Research Center, has received a $300,000 grant from the Lupus Research Institute to study the potential role of "genetic conflicts" in the development of lupus, an autoimmune disease.

Malik and colleagues want to find out whether a lost evolutionary arms race causes lupus autoimmunity.

"We want to determine whether autoimmunity when the body's immune system turns against itself results from an evolutionary arms race between ancient parasitic genes and the defense mechanisms that control them, which could provide a new model for understanding what causes lupus," said Malik, a member of the Hutchinson Center's Basic Sciences Division.

More than half of the human genome consists of parasitic "jumping genes," or endogenous retroelements, which can replicate and re-insert themselves into DNA. During millions of years of evolution, most of these genes have lost their ability to jump, but a tiny fraction are still capable of becoming active. Recently it has been discovered that some people with lupus carry a mutation in the TREX1 gene, which inhibits their body's ability recognize and attack these jumping genes when they become active. This led Malik and collaborator Richard McLaughlin, Ph.D., a research associate in Malik's lab, to theorize that autoimmunity may arise when cells can no longer recognize these jumping genes, or retroelements.

"The Lupus Research Institute grant will allow us to test this theory for the first time by analyzing genetic variation in the TREX1 gene and active retroelements, and look for evidence that each has influenced the evolution of the other," Malik said.

A native of India, Malik joined the Hutchinson Center faculty in 2003. He is also an affiliate assistant professor of genome sciences at the University of Washington School of Medicine and is a Howard Hughes Medical Institute Early Career Scientist.

As a researcher of genet
'/>"/>

Contact: Kristen Woodward
kwoodwar@fhcrc.org
206-667-5095
Fred Hutchinson Cancer Research Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Illuminating biology: An evolutionary perspective
2. Revealing the evolutionary history of threatened sea turtles
3. Details of evolutionary transition from fish to land animals revealed
4. Genetic based human diseases are an ancient evolutionary legacy
5. Flies may reveal evolutionary step to live birth
6. Evolution in action: Our antibodies take evolutionary leaps to fight microbes
7. Scientists uncover evolutionary keys to common birth disorders
8. Evolutionary process more detailed than previously believed, study shows
9. Dinosaur fossils fit perfectly into the evolutionary tree of life
10. Singapore-US scientists first to develop revolutionary microchip that uses 30 times less energy
11. Pubic hair provides evolutionary home for gorilla lice
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2015)... 2015   HOYOS Labs , a leading global ... that the Company will demonstrate multiple biometrics-based technologies under ... at Connect:ID on March 23 through 25, 2015, in ... highlight the IEEE Biometric Open Protocol Standard; free biometrics-based ... access control system. BOPS was invented by HOYOS Labs ...
(Date:3/20/2015)... Markets ( http://www.researchandmarkets.com/research/rswjb4/hand_geometry ) has announced the addition ... report to their offering. This report analyzes ... report provides separate comprehensive analytics for the US, ... Europe , Asia-Pacific , ... Annual estimates and forecasts are provided for the period 2013 ...
(Date:3/18/2015)... 18, 2015 As mobile payments become ... smart wallets and apps continue to be introduced into the ... the mobile payment industry in focus today are:  NXT-ID, Inc. ... BABA ), Apple Inc. (NASDAQ: AAPL ... Inc. (NASDAQ: FB ) NXT-ID, Inc. ...
Breaking Biology News(10 mins):HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 2HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 3Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 2Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 3Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 4Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 2Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 3Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 4Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 5Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 6
... This press release is also available in German . ... fuels of the future. It would be ideal to obtain ... electrolysis of water is a very energy intensive process, making ... generate it comes from the burning of fossil fuels. Photolysis, ...
... to compete in the Olympics, but scientists have raced cane ... be able to invade Melbourne, Adelaide or Hobart and are ... climate change. According to research by Dr Michael Kearney, ... and collaborators from Australia and the USA, the cane toad,s ...
... School of Music and Department of Brain and ... perfect pitch, and have found surprising results. , ... recognize and remember a tone without a referenceis ... had expected. Previous tests have overlooked these people ...
Cached Biology News:Molecular cubes in the sunlight 2Racing cane toads reveals they get cold feet on Southern Australia invasion 2Racing cane toads reveals they get cold feet on Southern Australia invasion 3'Perfect pitch' in humans far more prevalent than expected 2'Perfect pitch' in humans far more prevalent than expected 3
(Date:4/16/2015)... CA (PRWEB) April 16, 2015 ... the Buzz of BIO Contest for the ... Organization (BIO), the 2015 BIO International Convention will take ... Philadelphia, Pennsylvania. During the Buzz of BIO contest, industry ... to see present at the conference. The community voting ...
(Date:4/16/2015)... (PRWEB) April 16, 2015 According ... overexertion involving an outside source was ranked first ... includes injuries related to lifting, pushing, pulling, holding, ... in direct costs. The David Round Company takes ... committed to working hard to develop and design ...
(Date:4/16/2015)... , April 16, 2015  In recognition of World Hemophilia ... hemophilia advocacy groups to illuminate more than 15 prominent landmarks ... Boston,s Zakim Bridge and Prudential Tower, ... Orleans, Mercedes-Benz Superdome and Denver,s ... the evening of April 17, and coincide with hemophilia community ...
(Date:4/16/2015)... ON , April 16, 2015 /CNW/ - Bioenterprise Corporation ... its newest office in Charlottetown , ... the Prince Edward Island ADAPT Council for the commercialization ... looking forward to working with PEI ADAPT.  They have ... for more than a decade," explains Dave Smardon ...
Breaking Biology Technology:Proove Bisociences to Participate in the Buzz of BIO at the 2015 BIO International Convention 2Proove Bisociences to Participate in the Buzz of BIO at the 2015 BIO International Convention 3The David Round Company Helps Companies Meet OSHA Standards by Combining Safety, Ergonomics, and Productivity 2Biogen Shines A Light On Hemophilia Community By Illuminating U.S. Landmarks Red On World Hemophlia Day 2Biogen Shines A Light On Hemophilia Community By Illuminating U.S. Landmarks Red On World Hemophlia Day 3Biogen Shines A Light On Hemophilia Community By Illuminating U.S. Landmarks Red On World Hemophlia Day 4Bioenterprise Corporation Expands into the Maritimes 2
... L. A. Knapp, 1, 2 E. Lehmann, 2 L. Hennes, 3 , ... 3 , 1 Department of Biological Anthropology, ... Research Center, University of Wisconsin, , , ... Wisconsin Hospital and Clinics, Madison, Wisconsin, U.S.A. , ...
... Jaakola** and , T. Alatossava* , ... of Kajaani, University of Oulu, FIN-88600 , Sotkamo, Finland ... Jyvskyl, , PL 35, FIN-40351 Jyvskyl, Finland , ... , β-lactoglobulin (βLG) is a major whey protein found in ...
... Dr Albert J Ketterman and SHP Parakrama Karunaratne, Dept. ... , , ... In attempts to control Culex quinquefasciatus as a worldwide vector of , ... field populations , are sprayed with organophosphate ...
Cached Biology Technology:Separation of HLA-DRB Alleles by Denaturing Gradient Gel Electrophoresis using the DCode System 2Separation of HLA-DRB Alleles by Denaturing Gradient Gel Electrophoresis using the DCode System 3Separation of HLA-DRB Alleles by Denaturing Gradient Gel Electrophoresis using the DCode System 4Purification and Characterization of beta-Lactoglobulin Genetic Variants A and B Using Preparative Electrophoresis and Isoelectric Focusing 2Purification and Characterization of beta-Lactoglobulin Genetic Variants A and B Using Preparative Electrophoresis and Isoelectric Focusing 3Purification and Characterization of beta-Lactoglobulin Genetic Variants A and B Using Preparative Electrophoresis and Isoelectric Focusing 4Purification and Characterization of beta-Lactoglobulin Genetic Variants A and B Using Preparative Electrophoresis and Isoelectric Focusing 5Purification and Characterization of beta-Lactoglobulin Genetic Variants A and B Using Preparative Electrophoresis and Isoelectric Focusing 6Purification and Characterization of beta-Lactoglobulin Genetic Variants A and B Using Preparative Electrophoresis and Isoelectric Focusing 7Purification and Characterization of beta-Lactoglobulin Genetic Variants A and B Using Preparative Electrophoresis and Isoelectric Focusing 8Purification and Characterization of beta-Lactoglobulin Genetic Variants A and B Using Preparative Electrophoresis and Isoelectric Focusing 9Purification and Characterization of beta-Lactoglobulin Genetic Variants A and B Using Preparative Electrophoresis and Isoelectric Focusing 10Purification and Characterization of beta-Lactoglobulin Genetic Variants A and B Using Preparative Electrophoresis and Isoelectric Focusing 11Purification and Characterization of beta-Lactoglobulin Genetic Variants A and B Using Preparative Electrophoresis and Isoelectric Focusing 12Preparative Nondenaturing Gel Electrophoresis Used in the Purification of an Esterase Involved in Insecticide Resistance, Rev C 2Preparative Nondenaturing Gel Electrophoresis Used in the Purification of an Esterase Involved in Insecticide Resistance, Rev C 3
Ubiquitin-like protein 4A (Ubiquitin-like protein GDX). [Source:Uniprot/SWISSPROT;Acc:P11441] Antigen: Recombinant Protein Epitope Signature Tag (PrEST)....
AK6 Antibody...
Reacts with the 80 kDa fragment of the M-chain of human merosin....
Goat anti-mouse gamma chain-HRP...
Biology Products: