Navigation Links
Dictyostelium cells shown to lay 'breadcrumb trail' as first step in multicellular formation
Date:12/1/2008

When starved of their food source and then presented with a chemoattractant signal like cAMP, individual Dictyostelium cells acquire a polarized morphology and aggregate to form a migrating stream. This is the first step in a developmental program that culminates in the formation of a multicellular organism. Kriebel et al. show how this streaming response is coordinated at a single-cell level in the December 1, 2008 issue of the Journal of Cell Biology (www.jcb.org).

Besides acquiring a polarized morphology and beginning to chemotax, Dictyostelium cells respond to cAMP signals by making their own cAMP, thereby recruiting yet more cells to join the parade. The team previously discovered that ACAthe enzyme that makes cAMPis highly enriched at the back of migrating cells. They thus proposed that the attractant is released mainly from the rear of cells, which prompts fellow cells to align and generate head-to-tail streaming structures. Kriebel et al. now show that ACA is packaged into intracellular vesicles that cluster at the rear of cells in a process that is dependent on actin and microtubule networks. They also show that de novo protein synthesis is required to maintain the asymmetrical distribution of the ACA vesicles.

Interestingly, the ACA-containing vesicles themselves, not just their contents, are deposited behind the Dictyostelium cells like a breadcrumb trail as the cells crawl along. As cAMP is a small and diffusible molecule, perhaps the vesicles serve to package the chemoattractant so that it doesn't immediately diffuse away, says author Carole Parent.


'/>"/>

Contact: Rita Sullivan
rsullivan@rockefeller.edu
212-327-8603
Rockefeller University Press
Source:Eurekalert

Page: 1

Related biology news :

1. Wistar scientists find key to keeping killer T cells in prime shape for fighting infection, cancer
2. Rong Li Lab offers insight into adaptive ability of cells
3. Tiny protein provokes healthy bonding between cells
4. Childrens Hospital scientists achieve repair of injured heart muscle in lab tests of stem cells
5. Mammals can be stimulated to regrow damaged inner retina nerve cells
6. Penn scientists discover cells reorganize shape to fit the situation
7. Intraspinal implant of mesenchymal stem cells may not heal the demyelinated spinal cord
8. In the war against diseases, nerve cells need their armor
9. MIT creates tiny backpacks for cells
10. Scripps research scientists identify compounds for stem-cell production from adult cells
11. Lung airway cells activate vitamin D and increase immune response
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... A study recently published in the journal Carcinogenesis ... a new role for the protein adenomatous polyposis coli ... of cancer-related deaths in the U.S. , Lead author ... Biosciences and co-leader of the Cancer Biology program at ... of her career trying to understand the various activities ...
(Date:8/21/2014)... National University (ANU) team has successfully replicated one of ... biological systems powered by sunlight which could manufacture hydrogen ... is sunlight. It is an exciting prospect to use ... safely," said Dr Kastoori Hingorani, from the ARC Centre ... School of Biology. , Hydrogen offers potential as a ...
(Date:8/20/2014)... Aug. 20, 2014 George E. Fox, a John and ... of Houston (UH), was named a fellow in the International ... , Fox is one of four members two ... chosen as fellows in 2014. Fellows are elected every ... more than 500 members from more than 20 countries, the ...
Breaking Biology News(10 mins):Research offers insight into cellular biology of colorectal cancer 2Research offers insight into cellular biology of colorectal cancer 3Water and sunlight the formula for sustainable fuel 2UH professor named fellow by International Astrobiology Society 2
... in preventing fouling of ship bottoms. Researchers at the University ... barnacle to react to the substance, opening up the possibility ... and on the environment. Fouling of hulls is a ... well as large cargo ships. The University of Gothenburg has ...
... ashore in coastal Louisiana salt marshes, what will their ... Science Foundation (NSF) has awarded a rapid response grant ... colleagues to measure the impacts on Gulf Coast salt ... current time, and again at three months) and longer-term ...
... initial field observations that indicate that a dramatic rise ... in a large-scale bleaching event that has devastated coral ... of marine biologists was dispatched to investigate coral bleaching ... the northern tip of the island of Sumatra. The ...
Cached Biology News:Gene that causes barnacles to avoid ship hulls identified 2Grant to study effects of oil and dispersants on Louisiana salt marsh ecosystem 2Massive coral mortality following bleaching in Indonesia 2Massive coral mortality following bleaching in Indonesia 3
(Date:8/21/2014)... 21, 2014 2014 Deep ... is a professional and in-depth research report ... provides basic Seaweed Fertilizer information, including Seaweed ... structure as well as industry overview. This ... domestic market as well as global industry ...
(Date:8/21/2014)... 21, 2014 Telomere Biosciences, LLC (Telomere ... "TELO-20 for Dogs" with Telomerase Activation Complex ... the world for dogs. Telomeres are the protective ... the body. A wealth of ground-breaking research by ... Science and Aging, including Nobel laureates, has demonstrated ...
(Date:8/21/2014)... 21, 2014 Mathematic studies at the Program ... and funded by the Jeffrey Epstein VI Foundation , ... be visually identified for elimination. These aggressive cells are the ... shows a topological map of what to look for when ... for while tumor cells can be extracted from biopsy, it,s ...
(Date:8/21/2014)... , Aug. 21, 2014  Four-dimensional (4-D) ... behaviors based on external stimuli such as changes ... have a disruptive effect in multiple industries.  In ... business landscape by printing objects ranging from human ... automotive sectors. Logo - http://photos.prnewswire.com/prnh/20140820/138289 ...
Breaking Biology Technology:Internationals Seaweed Fertilizer Industry 2014 Development Trend Analysis in New Research Study at DeepResearchReports.com 2Internationals Seaweed Fertilizer Industry 2014 Development Trend Analysis in New Research Study at DeepResearchReports.com 3Telomere Biosciences Announces: TELO-20 for Dogs, the World's First Telomere-Lengthening Supplement for Dogs, to Promote Healthy Aging and Longevity 2Telomere Biosciences Announces: TELO-20 for Dogs, the World's First Telomere-Lengthening Supplement for Dogs, to Promote Healthy Aging and Longevity 3Science Power Jeffrey Epstein and Harvard University Fund Project to Visually Stop Tumor Growth 2Frost & Sullivan: 4-D Printing to Usher in Age of Low-Labor, Fast-Paced Product Manufacturing 2Frost & Sullivan: 4-D Printing to Usher in Age of Low-Labor, Fast-Paced Product Manufacturing 3Frost & Sullivan: 4-D Printing to Usher in Age of Low-Labor, Fast-Paced Product Manufacturing 4
... NameProtect , a Madison-based supplier of online security and ... a partnership with Corillian Corp. , an online ... ,The companies will jointly market the Corillian Fraud Detection ... companies' anti-fraud solutions. The pairing will team Fraud Detection ...
... . - Gov Jim Doyle on Thursday announced that ... projects from the Department of Commerce Technology Assistance Grant ... projects are as follows: , , Functional ... 2003 to provide DNA sequencing. It will receive a ...
... RedPrairie Corp ., a Waukesha-based supply chain ... are enabling Cooper Lighting , a ... its distribution operations and workforce productivity. , ... technology with RedPrairie's DLx Warehouse, slotting and ...
Cached Biology Technology:
... Ideal for cell culture scale-up, these ... 10 7 - 10 9 range ... bottles or spinner flasks. • High mechanical ... leak tested prior to shipping • Certified ...
BD BioCoat Collagen IV 150 mm Culture Dishes...
Gridded Cell Culture Petri Dish (20 mm molded in base), tissue-culture treated...
MAb to Desmoplakin I & II Desmoplakin I & II...
Biology Products: