Navigation Links
Dictyostelium cells shown to lay 'breadcrumb trail' as first step in multicellular formation
Date:12/1/2008

When starved of their food source and then presented with a chemoattractant signal like cAMP, individual Dictyostelium cells acquire a polarized morphology and aggregate to form a migrating stream. This is the first step in a developmental program that culminates in the formation of a multicellular organism. Kriebel et al. show how this streaming response is coordinated at a single-cell level in the December 1, 2008 issue of the Journal of Cell Biology (www.jcb.org).

Besides acquiring a polarized morphology and beginning to chemotax, Dictyostelium cells respond to cAMP signals by making their own cAMP, thereby recruiting yet more cells to join the parade. The team previously discovered that ACAthe enzyme that makes cAMPis highly enriched at the back of migrating cells. They thus proposed that the attractant is released mainly from the rear of cells, which prompts fellow cells to align and generate head-to-tail streaming structures. Kriebel et al. now show that ACA is packaged into intracellular vesicles that cluster at the rear of cells in a process that is dependent on actin and microtubule networks. They also show that de novo protein synthesis is required to maintain the asymmetrical distribution of the ACA vesicles.

Interestingly, the ACA-containing vesicles themselves, not just their contents, are deposited behind the Dictyostelium cells like a breadcrumb trail as the cells crawl along. As cAMP is a small and diffusible molecule, perhaps the vesicles serve to package the chemoattractant so that it doesn't immediately diffuse away, says author Carole Parent.


'/>"/>

Contact: Rita Sullivan
rsullivan@rockefeller.edu
212-327-8603
Rockefeller University Press
Source:Eurekalert

Page: 1

Related biology news :

1. Wistar scientists find key to keeping killer T cells in prime shape for fighting infection, cancer
2. Rong Li Lab offers insight into adaptive ability of cells
3. Tiny protein provokes healthy bonding between cells
4. Childrens Hospital scientists achieve repair of injured heart muscle in lab tests of stem cells
5. Mammals can be stimulated to regrow damaged inner retina nerve cells
6. Penn scientists discover cells reorganize shape to fit the situation
7. Intraspinal implant of mesenchymal stem cells may not heal the demyelinated spinal cord
8. In the war against diseases, nerve cells need their armor
9. MIT creates tiny backpacks for cells
10. Scripps research scientists identify compounds for stem-cell production from adult cells
11. Lung airway cells activate vitamin D and increase immune response
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/15/2016)... , Nov 15, 2016 Research and ... Global Forecast to 2021" report to their offering. ... ... USD 16.18 Billion by 2021 from USD 6.21 Billion in 2016, ... Growth of the bioinformatics market is driven by the ...
(Date:6/22/2016)... 22, 2016  The American College of Medical Genetics and ... Magazine as one of the fastest-growing trade shows during ... the Bellagio in Las Vegas . ... of growth in each of the following categories: net square ... number of attendees. The 2015 ACMG Annual Meeting was ranked ...
(Date:6/20/2016)... June 20, 2016 Securus Technologies, a ... solutions for public safety, investigation, corrections and monitoring ... involved, it has secured the final acceptance by ... for Managed Access Systems (MAS) installed. Furthermore, Securus ... to be installed by October, 2016. MAS distinguishes ...
Breaking Biology News(10 mins):
(Date:12/8/2016)... , Dec. 8, 2016 Savannah River ... technologies and selected NewTechBio,s NT-MAX Lake & ... based beneficial bacteria, in conjunction with Hexa Armor/ ... deficiencies with National Pollutant Discharge Elimination System requirements. ... experienced a steady history of elevated pH levels, ...
(Date:12/8/2016)... PHILADELPHIA , Dec. 8, 2016  Partnering to ... ecosystem, Ben Franklin Technology Partners of Southeastern ... Group ("IHG"), the parent company of Independence Blue Cross; ... today announced their intentions for a $6 million funding ... early-stage healthcare startups. Responding to a burgeoning ...
(Date:12/7/2016)... ... 07, 2016 , ... ACEA Biosciences, Inc. presented today updated ... trial for its lead drug candidate, AC0010, at the World Conference on Lung ... determine the safety, antitumor activity, and recommended phase II dosage of AC0010 in ...
(Date:12/7/2016)... ... December 07, 2016 , ... Huffman Engineering, ... become a Wonderware Certified System Integrator Partner. Huffman Engineering is the only ... , “The System Integrator Partner certification gives customers confidence that our engineers are ...
Breaking Biology Technology: