Navigation Links
Diabetes may clamp down on cholesterol the brain needs
Date:11/30/2010

memory loss and eating disorders than people without diabetes, and imaging studies have shown that people with diabetes have altered brain function compared to those without.

Additionally, the finding raises a question about potential interactions between anti-cholesterol drugs and diabetes.

In the Joslin study, scientists first examined gene expression in the hypothalamus of a mouse model of insulin-deficient (type 1) diabetes. They found decreased expression for almost all of the genes of cholesterol synthesis, including a gene called SREBP-2, which acts as a master regulator for cholesterol production. Similar findings were present in the cerebral cortex and other regions of the brain in these animals and also found in several other mouse models of diabetes. In the insulin-deficient animals, this phenomenon was associated with decreased cholesterol synthesis. Treatment of the mice with insulin, either by normal injection or injection into the fluid surrounding the brain, reversed the process.

"Our studies showed that these effects occurred in both the neurons and supporting 'glial' cells that help provide some nutrients to the neurons," says Kahn. "Ultimately this affects the amount of cholesterol that can get into the membranes of the neuron, which form the synapses and the synaptic vesiclesthe small structures that contain neurotransmitters."

Additionally, the Joslin work showed a connection between the decrease in brain cholesterol synthesis and appetite. When the scientists took normal mice and temporarily reduced cholesterol creation in the hypothalamus with a technique known as RNA interference, the animals started eating more and gained significant weight. Previous studies by other labs have demonstrated that diabetes may affect brain hormones involved in appetite regulation.


'/>"/>

Contact: Eric Bender
eric.bender@joslin.harvard.edu
617-309-2418
Joslin Diabetes Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Diabetes drug could work against Alzheimers
2. Registered dietitians play essential role in effective management of diabetes in adults
3. Common diabetes drug may halt growth of cysts in polycystic kidney disease
4. Greater food insecurity from recession poses increased risk to low income individuals with diabetes
5. Understanding diabetes at the molecular level
6. Cooperation in diabetes research
7. T cell discovery shows promise for Type 1 diabetes treatment: UBC-CFRI study
8. Garlic oil shows protective effect against heart disease in diabetes
9. National study finds strong link between diabetes and air pollution
10. Biologists discover biochemical link between biological clock and diabetes
11. Women with diabetes having more C-sections and fetal complications: study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/21/2014)... , Nov. 20, 2014 C-Labs LLC, ... the Internet of Things (IoT), today announced the appointment ... chief operating officer. Previously a strategic advisor to the ... and operations. Mr. Traynor is based out of the ... He reports to Chris Muench , Chief Executive ...
(Date:11/18/2014)... 2014  The Secure Identity & Biometrics Association ... announce the formation of The Airport Entry and ... Identity and Biometric Entry and Exit Solutions Framework ... support from BORDERPOL, the international non-profit organization that ... expertise regarding border security, traveler and migration systems. ...
(Date:11/18/2014)... The Parenteral Drug Association (PDA) today confirmed that ... and at least seven more will participate in the upcoming ... Hotel in Washington D.C. , Dec. 2-4. ... support from the regulatory agencies in the United ... our effort to help advance the use of metrics in ...
Breaking Biology News(10 mins):C-Labs Names Former Microsoft and Bsquare Executive as Chief Operating Officer 2Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 2Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 3FDA's Janet Woodcock, EMA's Emer Cooke Headline PDA Quality Metrics Conference 2
... fetus is smaller than expected for the number of weeks ... heart, health concerns as severe as brain damage can result. ... doctors to use ultrasound to track a baby,s health and ... are often incomplete, and obstetricians have had to rely on ...
... WI, NOVEMBER 9, 2009 -- Agricultural soils accumulate ... of their presence in wastes (sewage biosolids and manures) ... time. Regulations and guidelines for tolerable concentrations of these ... assumption that the toxic effects of the metals are ...
... ST. PAUL, Minn. Teenage women who are obese may be ... as adults compared to female teens who are not obese, ... print issue of Neurology , the medical journal of ... 238,371women from the Nurses, Health Study and Nurses, Health Study ...
Cached Biology News:Healthy babies by the numbers 2Additive copper-zinc interaction affects toxic response in soybean 2Teenage obesity linked to increased risk of MS 2
(Date:12/24/2014)... -- PharmaBoardroom,s new report, , Healthcare ... for free download , digs deep into this vibrant ... the sector today. One area where ... developing a homegrown pharmaceutical manufacturing base, even if the government,s ... way off. A cursory comparison with neighboring Morocco ...
(Date:12/22/2014)... 2014 The Center for Professional ... technical training across the life sciences industry, has partnered ... (SCDM) to provide the organization's members with discounted classroom ... to the more than 350 sessions across 80 course ... off when registering for a public course ...
(Date:12/22/2014)... -- GenomeDx Biosciences today announced that a new study ... test for prostate cancer, was able to predict rapid ... prostatectomy without adjuvant therapy. Although rapid metastasis in men ... genomics to identify these men who have a highly ... The study has been published online by the ...
(Date:12/22/2014)... TENN (PRWEB) December 22, 2014 Fertility ... Donor Egg Bank USA , a network of ... country. Through this partnership, patients have fast access to ... in vitro fertilization, IVF . Fertility Associates of Memphis ... offer this fertility treatment option. , Dr. William ...
Breaking Biology Technology:PharmaBoardroom Releases New Algeria Pharmaceuticals Report 2PharmaBoardroom Releases New Algeria Pharmaceuticals Report 3CfPIE Announces Partnership with the Society for Clinical Data Management 2CfPIE Announces Partnership with the Society for Clinical Data Management 3Study Published in European Urology Shows that the Decipher Prostate Cancer Classifier is Predictive of Rapid Metastasis in High-Risk Men who have had Prostate Surgery 2Study Published in European Urology Shows that the Decipher Prostate Cancer Classifier is Predictive of Rapid Metastasis in High-Risk Men who have had Prostate Surgery 3Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 3
... David H. Murdock Research Institute (DHMRI) today announced the ... a next step in the continued growth of the ... Kannapolis, NC. Driven by a mission to accelerate the ... of immune-related diseases, the DHMRI provides integrated, state-of-the-art genomic, ...
... energy-guru and favourite read of Bill Gates, Vaclav Smil,s gloomy ... Raynolds. "You need a hug," Raynolds said. ... took place on TVO,s The Agenda with Steve Paikan live ... is now archived at http://wgsi.org/events/tvos-agenda-steve-paikin-1 . THE ...
... June 8, 2011 Northwest Biotherapeutics (OTC.BB: NWBO) today ... its management team, adding several highly experienced executives.  Ms. ... Board since May 2007, has been appointed Chief Executive ... in the field of cancer immune therapies, is joining ...
Cached Biology Technology:David H. Murdock Research Institute Assumes Control of the Immune Tolerance Institute and Establishes a State of the Art Human Immune Monitoring Laboratory for Biomarker Discovery and Development 2David H. Murdock Research Institute Assumes Control of the Immune Tolerance Institute and Establishes a State of the Art Human Immune Monitoring Laboratory for Biomarker Discovery and Development 3High voltage! Power experts pull out all the stops at international energy meeting 2Northwest Biotherapeutics Announces Change and Expansion of Management Team 2Northwest Biotherapeutics Announces Change and Expansion of Management Team 3Northwest Biotherapeutics Announces Change and Expansion of Management Team 4Northwest Biotherapeutics Announces Change and Expansion of Management Team 5Northwest Biotherapeutics Announces Change and Expansion of Management Team 6
Liquid. 50 μg/ml in PBS, pH 7.4. PROTECT FROM LIGHT. A convenient form of propidium iodide useful for flow cytometry studies. RTECS SF7949600, CAS 25535-16-4, M.W. 668.4. ...
... cycler system is used for conventional PCR ... the MyCycler personal thermal cycler, which features ... 0.2 ml tubes or plates, programmable time, ... and block modes of temperature control. The ...
... ProteinChip arrays have been developed for ... samples. A variety of ProteinChip chemical ... according to their unique biochemical properties. ... allowing side-by-side sample comparison, and the ...
The Freeze 'N Squeeze DNA gel extraction kit uses a quick freeze-and-thaw cycle and centrifugation to draw 50-23,000 bp DNA out of agarose gel slices. The kit includes materials for 100 preps....
Biology Products: