Navigation Links
Diabetes makes it hard for blood vessels to relax
Date:1/31/2008

osed with the recommendation the supplement not be used by heart attack patients. The supplement still is widely marketed.

The findings of increased arginase I activity in diabetes may limit other therapeutic approaches proposed for early endothelial dysfunction such as oral L-arginine supplementation, Drs. Thomas L. Luscher and Jan Steffel, of the University of Zurich Cardiovascular Research Institute write in an accompanying editorial. Although dietary L-arginine supplementation has been shown to exert vascular protective effects in certain clinical settings, this approach is unlikely to be effective in diabetes, if the results of this study can be confirmed by patients in vivo. In fact, the findings of Romera et al may provide a possible explanation for the unexpected neutral or even adverse effects of oral L-arginine in some clinical studies, in particular patients with coronary artery disease and infarction.

A short intravenous course of L-arginine may provide short-term improvement in blood vessel tone, Dr. Romero notes. However most of L-arginine ingested goes directly to the liver to be broken down, not the bloodstream where it can promote relaxation of blood vessels, Dr. Romero says.

Arginase also is associated with vascular problems related to aging, hypertension, sickle cell disease, atherosclerosis and erectile dysfunction, Dr. Romero says. L-citrulline already is taken by some sickle cell patients to reduce breath-taking fibrosis in their lungs. In addition to helping the body turn toxins into urea that can be safely eliminated from the body, arginase also helps in collagen formation and cell proliferation, but too much can be bad. In fact, Drs. Caldwell and Romero are pursuing studies of how increased arginase activity may harden blood vessel walls.


'/>"/>

Contact: Toni Baker
tbaker@mcg.edu
706-721-4421
Medical College of Georgia
Source:Eurekalert

Page: 1 2

Related biology news :

1. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
2. Gender, coupled with diabetes, affects vascular disease development
3. Breakthrough research identifies how cells from pigs may cure diabetes
4. Botched production of insulin molecule may lead to diabetes
5. Joslin researchers uncover potential role of leptin in diabetes
6. Insulins brain impact links drugs and diabetes
7. Exercise improves thinking, reduces diabetes risk in overweight children
8. UVa Health System team uncovers genes role in type 1 diabetes
9. Childrens Hospital studying drug with the potential to prevent/delay onset of type 1 diabetes
10. JDRF awards University of Copenhagen professor with grant to conduct innovative diabetes research
11. Cancer and arthritis therapy may be promising treatment for diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/29/2014)... Food and Brand Lab pilot study, published in ... National School Lunch Program (NSLP) by 9% and overall ... Move to Schools (CMTS), an initiative of Michelle Obama,s ... to provide nutrition instruction to students and culinary advice ... event was held in an Upstate New York high ...
(Date:9/29/2014)... Texas at Arlington research team says recently identified radiation ... lab could open doors for homeland security and medical ... the Oct. 1 issue of Optics Letters , ... describe a new method to fabricate transparent nanoscintillators by ... a transparent ceramic is formed. A scintillator refers ...
(Date:9/29/2014)... bad rap, and understandably so. The grain-of-rice-sized insects are ... of acres in the Western U.S. and Canada over ... belief, these pests may not be to blame for ... through the region. Instead, weather and topography play a ... these bark-boring beetles. , New research led by the ...
Breaking Biology News(10 mins):Chefs move to schools can increase school meal participation and vegetable intake among students 2UT Arlington researchers develop new transparent nanoscintillators for radiation detection 2UT Arlington researchers develop new transparent nanoscintillators for radiation detection 3Tree killers, yes, fire starters, no: Mountain pine beetles get a bad rap, study says 2Tree killers, yes, fire starters, no: Mountain pine beetles get a bad rap, study says 3Tree killers, yes, fire starters, no: Mountain pine beetles get a bad rap, study says 4
... from Kent State University and the University of ... species Cycloprosopon dobrogea in eastern Romania. Previously unexamined, ... more than 150 million years ago during the ... crabs helps determine various aspects of biodiversity and ...
... St. Paul, Minn. (October 17, 2007) Deadlines ... reservations are quickly approaching for the 2007 National ... Symposium will be held December 12-14, 2007 at ... The 2007 symposium, organized by The American ...
... imagist and researcher at Harvard University,s Initiative in ... the 2007 Lennart Nilsson Award. Frankel was sited ... art and crystal-clear scientific illustrations both fascinating ... community alike. The Lennart Nilsson Award is ...
Cached Biology News:Deadlines for 2007 National Soybean Rust Symposium fast approaching 2Lennart Nilsson Award 2007 2
(Date:10/1/2014)... 2014 Weighing applications in pharmaceutical ... final product. However, while the pharmaceutical industry is ... as Good Manufacturing Practices (GMP) usually provide only ... manufacturer to interpret these guidelines and assess process ... METTLER TOLEDO experts have created a new white ...
(Date:10/1/2014)... -- Pfanstiehl has announced the launch of cGMP-produced, ... USA under ICH Q7 ... playing a key role in protein glycosylation.  Now, ... media supplementation with mannose can improve overall culture ... Dr. Christopher Wilcox , VP, Business Development ...
(Date:10/1/2014)... The participants committed to not only ... their own time adjusting, tweaking and testing virtual models ... ready for judging. , “I enjoyed being involved as ... “The entries showed a commendable range exploring the ... the print medium and the creativity of the contestants.” ...
(Date:10/1/2014)... September 30, 2014 In response ... tools to address sales, training and consumer engagement ... developed innovative mobile applications to turn their clients’ ... agency’s latest customized mobile app creations, are now ... , In partnership with Toyota, StudioPMG created a ...
Breaking Biology Technology:Comply with Weighing-Related Regulations in Pharma Manufacturing 2Pfanstiehl Launches cGMP-produced Mannose for Cell Culture Media Optimization & Glycoprotein Biosynthesis 2Array Architects Challenges Staff to Create with 3D Printer 2Digital Agency Studio PMG Launches New Case Studies on Website 2
... (NASDAQ: LMNX ) today announced that management ... to be held June 4-7 in New York. ... presentation by Patrick J. Balthrop, president and chief executive ... June 6, 2012.  The presentation will be webcast live and ...
... Inc. (Nasdaq: AUXL ) today announced that executive ... to be held June 4-7, 2012 at the Grand Hyatt ... and President, is scheduled to present an overview of the ... Monday, June 4, 2012. A breakout session will be held ...
... Research into conditions such as multiple sclerosis and ... stem cell research and life sciences facilities opened yesterday ... Royal is to unveil plaques this afternoon at the ... $38 million bio-incubator facility, Nine, in Edinburgh. ...
Cached Biology Technology:Luminex Corporation to Present at Jefferies 2012 Global Healthcare Conference 2Auxilium Pharmaceuticals, Inc. to Present at the Jefferies 2012 Global Healthcare Conference 2Auxilium Pharmaceuticals, Inc. to Present at the Jefferies 2012 Global Healthcare Conference 3Auxilium Pharmaceuticals, Inc. to Present at the Jefferies 2012 Global Healthcare Conference 4Scotland opens stem cell research center and bio-medical incubator 2
... plus software to note when an animal is ... and trigger a penaltyThe Spatial Behavior line is ... video camera, frame grabber, and feature extraction software ... and up to 6 moving animals. Software ...
... Magnetofection technology, SilenceMag is the most ... rapid and easy to use, SilenceMag ... Specifically designed for siRNA delivery, SilenceMag ... low doses of siRNA.,SilenceMag formulation gives ...
Denhardt's Solution is a mixture of blocking agents used in membrane-based hybridization protocols. The solution contains 1% Ficoll (type 400) 1% polyvinylpyrrolidone and 1% bovine serum albumin. Ste...
... system from Molecular Devices provides precise dispensing ... The system handles a variety of plate ... and 1536-welland is the first to handle ... optimized to dispense from four different channels ...
Biology Products: