Navigation Links
Diabetes drug shows promise in fighting lethal cancer complication
Date:9/24/2009

st that same tendency toward insulin resistance.

The scientists injected mice with colon cancer cells to mimic one of several digestive-system cancers strongly associated with the development of cachexia. Less than two weeks after the cancer started growing, these mice had become insulin resistant. Control mice without tumors had normal insulin sensitivity. Insulin resistance means that the presence of insulin does not initiate the transfer of sugar, or glucose, from the blood into the tissues, where it is used for energy.

Just three days later, the mice with cancer weighed, on average, 20 percent less than control mice with no tumors; weight loss of at least 5 percent is considered to be a sign of cachexia in humans. By day 19, the total muscle weight in mice with cancer decreased by 29 percent and the weight of their fat tissue dropped by 73 percent. Such rapid loss of muscle and fat indicated these mice had indeed developed cachexia.

"These data provide evidence that in mice with colon cancer tumors, insulin resistance may be involved in the development of cachexia rather than occur as a result of cachexia," Belury said. "And the key here is that people and animals with cachexia do not want to be losing weight. They can eat more and it doesn't matter. There's something internally that's driving this fat and muscle loss."

In the second study, the scientists tested whether rosiglitazone could "rescue" the insulin resistance in mice with colon cancer.

In this study, mice were fed a high-fat diet and randomized into three groups: mice with and without tumors receiving a saline solution as a control, and mice with tumors treated with daily injections of rosiglitazone.

Within eight days, the mice with cancer receiving the rosiglitazone showed more sensitivity to insulin than did the mice with tumors that received no medication. The insulin sensitivity of the medicated mice matched that of mice without tumors.


'/>"/>
Contact: Martha Belury
belury.1@osu.edu
614-292-1680
Ohio State University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. 1 million euro EU grant for MDC diabetes researcher Dr. Francesca M. Spagnoli
2. Diabetes drug kills cancer stem cells in combination treatment in mice
3. Size of fat cells and waist size predict type 2 diabetes in women
4. Medicine wheel model for nutrition shows promise for control of type 2 diabetes
5. JDRF-funded studies show regular CGM use increases diabetes control for all age groups
6. Scientists discover new genetic variation that contributes to diabetes
7. Diabetes advance: Researchers find gene that causes resistance to insulin
8. DNA mutations linked to diabetes
9. UCF discovery could open door to obesity, diabetes treatments
10. Stimulus funding helps K-State biochemist study eyes lens in diabetes, galactosemia patients
11. Common allergy drug reduces obesity and diabetes in mice
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... man-made form of insulin delivered by nasal spray may ... with mild cognitive impairment and Alzheimer,s disease dementia, according ... Forest Baptist Medical Center. The study,s subjects ... (MCI) or mild to moderate Alzheimer,s dementia (AD). Those ...
(Date:1/22/2015)... POINT ROBERTS, Washington , January 20, 2015 ... technology and tech stocks, releases video from the CES 2015 ... security consultant Apollo Robbins . Apollo shows ... Wocket™ biometric smart wallet, a product of NXT-ID, Inc. (NASDAQ: ...
(Date:1/22/2015)... January 22, 2015 , ... The European Patent Office to present a video retrospective ... nominations to be featured: Christofer Toumazou and Sophie ... finalists and winners of the Award   Starting on ...
Breaking Biology News(10 mins):Nasal Spray with Insulin Equivalent Shows Promise as Treatment for Adults with Mild Cognitive Impairment, Alzheimer's Dementia 2Nasal Spray with Insulin Equivalent Shows Promise as Treatment for Adults with Mild Cognitive Impairment, Alzheimer's Dementia 3Apollo Robbins Talks about the Illusion of Personal Safety and How Easily Your Wallet is Stolen; If a Wocket Wallet is Stolen the Thief Can't do Anything With it! 2Apollo Robbins Talks about the Illusion of Personal Safety and How Easily Your Wallet is Stolen; If a Wocket Wallet is Stolen the Thief Can't do Anything With it! 3Ten Years of the European Inventor Award: A Retrospective Look at the Inventors and Ideas That Have Changed Our Lives 2Ten Years of the European Inventor Award: A Retrospective Look at the Inventors and Ideas That Have Changed Our Lives 3
... scientist who has made ground-breaking discoveries in human genetics has ... in the United States of America. Professor Patricia ... in a human, specifically the 47,XXY constitution in males with ... an extra chromosome, causing symptoms such as infertility and tall ...
... scientist may have found a way to cut the amount of ... ingredient of the brewer,s art: hops. Cattle, deer, sheep, ... occurring bacteria to aid digestion of grass and other fibrous plants ... rumen. The problem, according to ARS microbiologist Michael Flythe, comes ...
... corresponding to 730 regions on the human genome by ... genome that were not charted in the reference map ... of those sequences are either missing, fragmented or misaligned ... on the same samples," said Dr. Evan Eichler, senior ...
Cached Biology News:National Academy of Sciences recognizes Southampton genetics scientist 2New methods identify thousands of new DNA sequences missing from the human genome reference map 2New methods identify thousands of new DNA sequences missing from the human genome reference map 3
(Date:1/23/2015)... , Jan. 23, 2015  Array BioPharma Inc. (NASDAQ: ... reached a definitive agreement with Novartis Pharma AG to ... currently in Phase 3 development.  This agreement is conditional on ... PLC (GSK) on April 22, 2014, which are expected to ...
(Date:1/22/2015)... 2015  Transwestern | RBJ today announces the firm brokered a ... Shire a leading biopharmaceutical company, at Two Ledgemont Center in ... Robert Richards , president, and Brian Cohen , senior ... five-floor building at 95 Hayden Ave. Photo - ...
(Date:1/22/2015)... 2015 The laboratory information management systems ... a number of technological advancements due to factors such ... need to integrate healthcare systems, and increasing government support ... system integration. Key players in the market focus on ...
(Date:1/22/2015)... 22, 2015 zFlo Motion , a ... announce an exciting product from a new partner. STT-Systems ... over the past 15 years, with offerings in the optical-motion ... 3D IMU system (inertial measurement unit), iSen, is opening eyes ...
Breaking Biology Technology:Array Announces Agreement To Acquire ENCORAFENIB (LGX818) 2Array Announces Agreement To Acquire ENCORAFENIB (LGX818) 3Array Announces Agreement To Acquire ENCORAFENIB (LGX818) 4Array Announces Agreement To Acquire ENCORAFENIB (LGX818) 5Array Announces Agreement To Acquire ENCORAFENIB (LGX818) 6Array Announces Agreement To Acquire ENCORAFENIB (LGX818) 7Transwestern | RBJ Advises Shire in 202,000 SF Lease, Creating Boston's Largest Suburban Biotech Campus 2Laboratory Information Management Systems Market is Expected to Reach $1,323.6 Million by 2019 - New Research Report by MarketsandMarkets 2Laboratory Information Management Systems Market is Expected to Reach $1,323.6 Million by 2019 - New Research Report by MarketsandMarkets 3Laboratory Information Management Systems Market is Expected to Reach $1,323.6 Million by 2019 - New Research Report by MarketsandMarkets 43D Motion Capture Just Got Easy 2
... ... announced that its Vice President of eLearning and Informatics earned the ... Society for Training and Development (ASTD) Certification Institute. Michelle Flewell ... training experience and is responsible for the development of the company,s ...
... ... Human Anthrax Vaccine Program must be stopped. Scott Miller and Company ... one-hour television documentary "Fatal Immunity: The Human Anthrax Vaccine Story" to inform ... science turned into for-profit human anthrax vaccines with no accountability to its ...
... Nov. 4 Onyx Pharmaceuticals, Inc. (Nasdaq: ONXX ... Credit Suisse 18th Annual Healthcare Conference on Wednesday, November ... Time). Interested parties may access a live webcast ... http://www.onyx-pharm.com/view.cfm/32/Event-Calendar , It is recommended that listeners ...
Cached Biology Technology:BioSoteria eLearning Executive Michelle Nolin Flewell Earns Certification 2BioSoteria eLearning Executive Michelle Nolin Flewell Earns Certification 3BioSoteria eLearning Executive Michelle Nolin Flewell Earns Certification 4Scott Miller's 'A Call To Arms' And 'Fatal Immunity' Are Available For World-Wide Licensing 2Scott Miller's 'A Call To Arms' And 'Fatal Immunity' Are Available For World-Wide Licensing 3Scott Miller's 'A Call To Arms' And 'Fatal Immunity' Are Available For World-Wide Licensing 4Scott Miller's 'A Call To Arms' And 'Fatal Immunity' Are Available For World-Wide Licensing 5Scott Miller's 'A Call To Arms' And 'Fatal Immunity' Are Available For World-Wide Licensing 6Scott Miller's 'A Call To Arms' And 'Fatal Immunity' Are Available For World-Wide Licensing 7