Navigation Links
Diabetes drug shows promise in fighting lethal cancer complication
Date:9/24/2009

COLUMBUS, Ohio Insulin resistance, the hallmark of type 2 diabetes and a condition often associated with obesity, is paradoxically also an apparent contributor to muscle wasting and severe fat loss that accompanies some cancers, according to new research.

And in an animal study, a diabetes drug that promotes insulin sensitivity slowed the progression of muscle wasting and fat loss, the main consequences of a syndrome called cachexia, in mice with colon cancer tumors.

Though it remains unknown whether that drug, rosiglitazone, has potential to prevent cachexia in humans with cancer, the finding led researchers to believe that curbing insulin resistance in cancer patients could improve their quality of life.

Research suggests that cachexia is responsible for between one-fifth and one-third of all cancer deaths.

The insulin resistance and cachexia both appear to be connected to inflammation induced either by tumors themselves or by secretions from tumors that activate an immune response, the researchers say.

"Insulin resistance usually follows obesity. In this case, it precedes uncontrollable fat loss," said Martha Belury, senior author of the study and a professor of human nutrition at Ohio State University. "The insulin resistance is the process we've identified that occurs soon after tumors form. So if we can change that part of the disease, we might be able to change the progression and trajectory of how fast fat and muscle are lost as well. That's our goal."

The research appears online and is scheduled for future print publication in the International Journal of Cancer.

Belury and colleagues conducted two experiments. In the first, the researchers sought to demonstrate that animals developed insulin resistance shortly after they developed cancer and before muscle and fat loss became evident. In the second, they tested the effectiveness of the insulin sensitizing drug rosiglitazone again
'/>"/>

Contact: Martha Belury
belury.1@osu.edu
614-292-1680
Ohio State University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. 1 million euro EU grant for MDC diabetes researcher Dr. Francesca M. Spagnoli
2. Diabetes drug kills cancer stem cells in combination treatment in mice
3. Size of fat cells and waist size predict type 2 diabetes in women
4. Medicine wheel model for nutrition shows promise for control of type 2 diabetes
5. JDRF-funded studies show regular CGM use increases diabetes control for all age groups
6. Scientists discover new genetic variation that contributes to diabetes
7. Diabetes advance: Researchers find gene that causes resistance to insulin
8. DNA mutations linked to diabetes
9. UCF discovery could open door to obesity, diabetes treatments
10. Stimulus funding helps K-State biochemist study eyes lens in diabetes, galactosemia patients
11. Common allergy drug reduces obesity and diabetes in mice
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/19/2014)... Some infants born with neonatal abstinence syndrome (NAS) ... difficult time going through withdrawal than others, but ... genetic and epigenetic (when genes are turned on ... potential factors, researchers at Boston University School of ... a first of its kind study to identify ...
(Date:8/19/2014)... Center at San Antonio and The University of Texas ... more than $750,000 in grants through the San Antonio ... 2003, SALSI is a model of how a general ... join forces for greater research and graduate education. , ... on public health issues and diseases of global impact. ...
(Date:8/19/2014)... 2014A new ovoid structure discovered in the Nakhla Martian ... variety of minerals, and shows evidence of undergoing a ... the permafrost and mixing of surface and subsurface fluids. ... analytical studies to determine the origin of this new ... ovoid formed, point to the most likely conclusion, and ...
Breaking Biology News(10 mins):In-utero methadone, Subutex exposure could alter gene expression, cause severe Neonatal Abstience Syndrome 2San Antonio Life Sciences Institute awards $750,000 to innovators 2San Antonio Life Sciences Institute awards $750,000 to innovators 3Life on Mars? Implications of a newly discovered mineral-rich structure 2
... the ends of bones where they meet in a ... can lead to degenerative disease. Treatments and experimental approaches ... but currently there is no method to fully restore ... delivery of therapeutic proteins to the injured site is ...
... of good advice to help us avoid becoming obese, such ... surprising piece of advice based on a promising area of ... that certain viruses may cause obesity, in essence making obesity ... a new study, "Adipogenic potential of multiple human adenoviruses in ...
... depression-like social withdrawal syndrome, repeated defeat by dominant animals ... its brain that could help to explain why depression ... the National Institutes of Health's (NIH) National Institute of ... this animal model of depression, silencer molecules turned off ...
Cached Biology News:Stem cells from muscles can repair cartilage 2Stem cells from muscles can repair cartilage 3Contagious obesity? Identifying the human adenoviruses that may make us fat 2Contagious obesity? Identifying the human adenoviruses that may make us fat 3Contagious obesity? Identifying the human adenoviruses that may make us fat 4Depression model leaves mice with molecular scar 2
(Date:8/18/2014)... , Aug. 18, 2014 BioElectronics ... advanced consumer medical devices said that its ... interviewed by CEOLIVE.TV as part of its ... interview is available at http://ceolive.tv/bioelectronics-corp-otc-biel/biel-videos/2282-ceolive-tv-interview-bioelectronics-corp-otcqb-biel ... explains to investors the unique advantages of ...
(Date:8/18/2014)... , August 18, 2014 ... Bioreactor Systems Market, By Application (Municipal Wastewater Treatment ... Flat Sheet and Multi Tubular), By Configuration (Internal/Submerged ... 2019", published by MarketsandMarkets, The market for membrane ... by 2019, growing at a CAGR of 15.28% ...
(Date:8/16/2014)... 2014 Firms in the ... and advisory services to businesses, government bodies and ... services are highly diverse as operators assist a ... from geological and geophysical consulting services to risk ... past five years, the recovery of the Canadian ...
(Date:8/15/2014)... 2014 Actor Robin Williams’ suicide has ... NBC’s Today Show reports, someone commits suicide every 13 ... of depression from the outside in, I contend that ... underlying cause from the inside out,” says neuroscientist Cynde ... , “Some of the accounts of Williams’ suicide have ...
Breaking Biology Technology:BioElectronics EVP Dr. Deepak Kotak Interviewed on CEO Live 2BioElectronics EVP Dr. Deepak Kotak Interviewed on CEO Live 3Membrane Bioreactor Systems Market Worth $2,927 Million by 2019 2Membrane Bioreactor Systems Market Worth $2,927 Million by 2019 3Scientific and Economic Consulting in Canada Industry Market Research Report Now Available from IBISWorld 2Scientific and Economic Consulting in Canada Industry Market Research Report Now Available from IBISWorld 3Neurofeedback Helps Alleviate the Underlying Causes of Depression 2Neurofeedback Helps Alleviate the Underlying Causes of Depression 3
... a new generation of piezoelectric nanogenerators with two types ... to be the first self-powered nanometer-scale sensing devices that ... The new devices can measure the pH of liquids ... current produced from mechanical energy in the environment. ...
... FRANCISCOScientists at Carnegie Mellon University,s Department of Chemistry and ... state-of-the-art in live cell fluorescent imaging by developing a ... from violet to the near-infrared. The new technology, ... of individual proteins in living cells in real time. ...
... ... of Business Award in the Commercial Site category by the Small Business Commerce Association (SBCA). ... identified through statistical research and monthly surveys. , ... Emeryville, CA (PRWEB) March 25, 2010 -- BioSoteria, Inc ., a ...
Cached Biology Technology:Researchers use improved nanogenerators to power sensors based on zinc oxide nanowires 2Researchers use improved nanogenerators to power sensors based on zinc oxide nanowires 3Carnegie Mellon scientists create rainbow of fluorescent probes 2Drug Safety Firm BioSoteria Receives 2009 Best of Business Award 2
Mouse monoclonal [N7519] to NR0B2 ( Abpromise for all tested applications). Antigen: E.coli expressed recombinant full length protein (Human) NR0B2 Entrez Gene ID: 8431 Swiss Protein ID: ...
Rabbit polyclonal to BCA1 ( Abpromise for all tested applications). Antigen: Generated using E.coli expressed mouse BCA1. Entrez GeneID: 10563 SWISS Protein ID: O43927...
PKC Sampler Kit 10 mu g each...
Purified anti-SOCS3...
Biology Products: