Navigation Links
Diabetes drug kills cancer stem cells in combination treatment in mice
Date:9/14/2009

Dana-Farber Cancer Institute and HMS associate professor of medicine, who was not involved in the study

Cancer stem cells are a shifty target, Polyak said. For example, any cancer cell can acquire the properties of a cancer stem cell, and cancer stem cells can change into non-stem cancer cells, which can be just as deadly. Clinical trials in people are needed to test these ideas, Polyak said.

The Struhl paper is an offshoot of a larger project in his lab to systematically track how gene activity changes when cells transform into cancer. These changes were remarkably similar to gene dynamics in diabetes and other inflammatory conditions.

The researchers reasoned that if a common genetic pathway underlies different diseases, drugs that work against one disease might work against another. In a screen, the most effective drug inhibiting the transformation of cells into cancer was metformin, which led to the experiments in this paper.

The team was further encouraged by the low dose of metformin needed for the effect in the laboratory, compared to the amount needed for analogous molecular experiments in basic diabetes research. The relative dosage in people for treating or preventing cancer is unknown and untested.


'/>"/>

Contact: Carol Cruzan Morton
carol_morton@hms.harvard.edu
617-432-3121
Harvard Medical School
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
2. Gender, coupled with diabetes, affects vascular disease development
3. Breakthrough research identifies how cells from pigs may cure diabetes
4. Botched production of insulin molecule may lead to diabetes
5. Joslin researchers uncover potential role of leptin in diabetes
6. Insulins brain impact links drugs and diabetes
7. Exercise improves thinking, reduces diabetes risk in overweight children
8. UVa Health System team uncovers genes role in type 1 diabetes
9. Childrens Hospital studying drug with the potential to prevent/delay onset of type 1 diabetes
10. JDRF awards University of Copenhagen professor with grant to conduct innovative diabetes research
11. Cancer and arthritis therapy may be promising treatment for diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/15/2014)... 2014   Neurotechnology , a provider of ... of the VeriLook Surveillance 3.0 software development ... biometric face identification using live video streams from ... new version not only identifies faces in a ... while they are moving through the video frame. ...
(Date:10/14/2014)... sequenced the house fly genome for the first time, ... an insect that thrives in pathogen-rich dung piles and ... the journal Genome Biology , will increase understanding ... flies quickly adapt to resist insecticides, which could lead ... domestica) carry and transmit more than 100 human and ...
(Date:10/14/2014)... – Scientists from The Scripps Research Institute (TSRI) have ... Health (NIH) to lead an investigation of Lassa fever ... Africa. The study aims to understand how Lassa fever ... others survive the inflection. , "The ultimate goal ... how Lassa fever virus causes disease and develop new ...
Breaking Biology News(10 mins):VeriLook Surveillance 3.0 SDK Identifies Faces and Moving Objects, Differentiates Pedestrians from Other Moving Objects in Video Surveillance Systems 2VeriLook Surveillance 3.0 SDK Identifies Faces and Moving Objects, Differentiates Pedestrians from Other Moving Objects in Video Surveillance Systems 3House fly genome reveals expanded immune system 2Scripps Research Institute team receives $6.6 million to investigate deadly Lassa virus 2
... PennsylvaniaOn Tuesday, August 3rd, as part of the ... a team of scientists will discuss the environmental ... Home to some of the most diverse habitats ... being permanently altered by mountaintop removal and valley ...
... elected ten new Fellows of the Society for 2010. ... one or more of the following: research, teaching, extension, ... Entomology 2010 -- ESA,s Annual Meeting -- which will ... Dr. Gary J. Blomquist received his B.S. degree in ...
... Stellwagen Bank National Marine Sanctuary, such as halibut and ... ago, according to a new NOAA report released today ... National Marine Sanctuaries Conservation Series report, "Stellwagen Bank Marine ... sanctuary that are resilient, but have suffered declines in ...
Cached Biology News:Ecologists to discuss impacts of mountaintop mining at special ESA symposium 2Ecologists to discuss impacts of mountaintop mining at special ESA symposium 3Entomological Society of America names 2010 Fellows 2Entomological Society of America names 2010 Fellows 3Entomological Society of America names 2010 Fellows 4Entomological Society of America names 2010 Fellows 5Entomological Society of America names 2010 Fellows 6Entomological Society of America names 2010 Fellows 7Entomological Society of America names 2010 Fellows 8Entomological Society of America names 2010 Fellows 9Top predators and biodiversity historically pressured in Stellwagen Bank National Marine Sanctuary 2
(Date:10/22/2014)... Ras Al Khaimah, UAE (PRWEB) October 22, 2014 ... in game-changing life science and healthcare projects, announces the ... MBBS MRCGP DRCOG DCH to its advisory team. Dr. ... research advisory team. , A graduate of ... Dr. Siddiqui was subsequently degreed in medicine in 2001. ...
(Date:10/22/2014)... 2014 Nuvilex, Inc. (OTCQB: NVLX) – According ... worldwide are living with diabetes, with  that number expected ... global market for diabetes treatments is approximately $500 billion.  ... died from pancreatic cancer.  Pancreatic cancer is the fourth ... the United States , and according ...
(Date:10/20/2014)... 20, 2014 Convey Computer , ... team from Iowa State University won first place in ... a Convey HC-2ex, the team’s solution achieved the highest ... than the second place finisher. , Experts from all ... the month long challenge, using a variety of design ...
(Date:10/20/2014)... BOSTON , Oct. 20, 2014 ... commercialization company tackling big healthcare problems, announced today ... investment round, with participation from Invesco Perpetual, a ... be used to drive PureTech,s existing pipeline forward ... technologies. "PureTech has the scientific creativity to really ...
Breaking Biology Technology:Dr. Yousef Siddiqui joins the Grace Century Advisory Team 2Nuvilex Brief Analyst Report: Thinking Outside the Box by BrokerBank Securities, Inc. 2Team from Iowa State Wins 2014 MemoCODE Design Contest Using Convey HC-2ex 2Team from Iowa State Wins 2014 MemoCODE Design Contest Using Convey HC-2ex 3PureTech Announces Expansion with Oversubscribed $55M Funding Round 2PureTech Announces Expansion with Oversubscribed $55M Funding Round 3PureTech Announces Expansion with Oversubscribed $55M Funding Round 4PureTech Announces Expansion with Oversubscribed $55M Funding Round 5PureTech Announces Expansion with Oversubscribed $55M Funding Round 6
... Discovery and Validation of New Biomarker Panels , ... Medicine, Incorporated (RBM), the world,s leading multiplexed biomarker ... most comprehensive collection of quantitative immunoassays for use ... and diagnostic development. The new service, DiscoveryMAP(TM) v ...
... ... NC and will include additional stability storage space, additional retain sample storage, and a ... ... worldwide provider of long-term and short term storage of stability samples, sample management, and ...
... Oclaro, Inc. (Nasdaq: OCLR ) has ... biomedical and analytical instrumentation markets. Oclaro filters are used ... and analytical applications, including clinical diagnostics, drug discovery, gene ... from the Oclaro filter portfolio are on display at ...
Cached Biology Technology:Rules-Based Medicine, Inc. Launches DiscoveryMAP(TM) Service for Drug and Diagnostic Development 2Rules-Based Medicine, Inc. Launches DiscoveryMAP(TM) Service for Drug and Diagnostic Development 3Precision Stability Storage Announces Upcoming Expansion 2Precision Stability Storage Announces Upcoming Expansion 3Oclaro(TM) Hits Milestone With Clarity(TM) Fluorescence Filters 2Oclaro(TM) Hits Milestone With Clarity(TM) Fluorescence Filters 3
Caliper offers a wide array of standard LabChip products designed to be used in combination with our AMS 90 and LabChip 3000 microfluidic platforms....
... 100-120 and 220-240 V, is a microfluidics-based ... gel-based electrophoresis, including some data analysis, in ... for protein analysis (it does not include ... The system includes the electrophoresis station, priming ...
...
... Grace's medium was originally formulated to ... the Australian emperor gum moth,Antherea eucalypti. The ... to more closely resembleAnthereahemolymph. The cell lines ... the first continuous lines developed. The basal ...
Biology Products: