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Diabetes Research Institute develops oxygen-generating biomaterial
Date:3/1/2012

od vessels) is formed, providing natural oxygen delivery to the insulin-producing cells."

In the study, the researchers also used a 3D model, similar to the bioengineered scaffold, to demonstrate that the oxygen-generating material was able to prevent cell death due to inadequate oxygen levels. With these promising results, future studies are focused on translating these studies to implanted grafts, with the end goal of preserving islet viability during the precarious engraftment period.

"This novel method for sustained oxygen delivery within the microenvironment of tissue-engineered sites, could be critically important to improve the survival of transplanted cellular products. The new platform technology could be particularly useful during the delicate post-implantation phase, in which new blood vessels are growing to provide full nutritional and oxygen support to the transplanted tissue," said Dr. Camillo Ricordi, DRI scientific director.

"We are very encouraged by the outcome of this study and its implications toward our goal of translating these findings to the millions of people living with diabetes," added Dr. Stabler.


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Contact: Lori Weintraub
Lweintraub@drif.org
954-964-4040
Diabetes Research Institute Foundation
Source:Eurekalert

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