Navigation Links
Diabetes Research Institute develops oxygen-generating biomaterial

Miami, FL March 1, 2012 -- Scientists at the Diabetes Research Institute have developed a revolutionary technique to provide critical oxygen for maintaining the survival of insulin-producing cells. This is the first time that scientists have been able to successfully deliver oxygen locally to beta cells using a biomaterial. The results of the study, which represents a major step toward the goal of developing an alternative site to house insulin-producing cells, were just published in the prestigious journal Proceedings of the National Academy of Sciences (PNAS).

One of the major problems with the transplantation of cells, particularly beta cells, is meeting the high nutrient demand of these cells following transplantation. During the initial days of implantation, these cells do not have a functioning vascular network feeding oxygen to the cells, thus cells become starved and large cell loss occurs.

The DRI team, led by Dr. Cherie Stabler, developed a novel oxygen-generating material (termed PDMS-CaO2), which has the capacity to generate this critical element when exposed to water. This spontaneous generation of oxygen creates a nutrient-rich environment with sustained oxygen supplementation for more than six weeks. With this unique biomaterial system, the duration and amount of oxygen generated can be elegantly controlled, thereby providing the ideal environment for the cells. The potential of this technique to enhance beta cell survival with the use of this material was illustrated by incubating beta cells and islets in conditions that mimic the native pancreas.

"We have been working to create an optimal environment for housing transplanted islets that mimics the native pancreas, akin to a 'mini organ,' and this study represents a significant step toward that goal," says Dr. Cherie Stabler. "This oxygen-generating biomaterial provides the supplemental oxygen needed by the islets and serves as a bridge until the vascular bed (blood vessels) is formed, providing natural oxygen delivery to the insulin-producing cells."

In the study, the researchers also used a 3D model, similar to the bioengineered scaffold, to demonstrate that the oxygen-generating material was able to prevent cell death due to inadequate oxygen levels. With these promising results, future studies are focused on translating these studies to implanted grafts, with the end goal of preserving islet viability during the precarious engraftment period.

"This novel method for sustained oxygen delivery within the microenvironment of tissue-engineered sites, could be critically important to improve the survival of transplanted cellular products. The new platform technology could be particularly useful during the delicate post-implantation phase, in which new blood vessels are growing to provide full nutritional and oxygen support to the transplanted tissue," said Dr. Camillo Ricordi, DRI scientific director.

"We are very encouraged by the outcome of this study and its implications toward our goal of translating these findings to the millions of people living with diabetes," added Dr. Stabler.


Contact: Lori Weintraub
Diabetes Research Institute Foundation

Related biology news :

1. VTT searches for novel biomarkers and targets for preventing or treating Type 2 diabetes
2. Diabetes risk factors in young Sri Lankans much higher than previously thought
3. Largest-ever gene study of Type 2 diabetes finds variants across many ethnic groups
4. Body clock receptor linked to diabetes in new genetic study
5. Genetic regulation of metabolomic biomarkers - paths to cardiovascular diseases and type 2 diabetes
6. La Jolla Institute scientist takes quest to conquer Type 1 diabetes to the next level
7. La Jolla Institute researchers identify pivotal immune cell in Type 1 diabetes in humans
8. UCSF, Sanofi collaborate to find new diabetes cures
9. How poor maternal diet can increase risk of diabetes -- new mechanism discovered
10. How poor maternal diet can increase risk of diabetes - new mechanism discovered
11. Study finds air pollution linked to diabetes and hypertension in African-American women
Post Your Comments:
(Date:4/28/2016)... -- First quarter 2016:   , Revenues ... first quarter of 2015 The gross margin was 49% ... and the operating margin was 40% (-13) Earnings per ... from operations was SEK 249.9 M (21.2) , Outlook ... 7,000-8,500 M. The operating margin for 2016 is estimated ...
(Date:4/15/2016)... CHICAGO , April 15, 2016  A ... companies make more accurate underwriting decisions in a ... offering timely, competitively priced and high-value life insurance ... health screenings. With Force Diagnostics, rapid ... and lifestyle data readings (blood pressure, weight, pulse, ...
(Date:3/31/2016)... 31, 2016   ... the "Company") LegacyXChange is excited to release ... soon to be launched online site for trading 100% ... ) will also provide potential shareholders a sense of ... to an industry that is notorious for fraud. The ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... NY (PRWEB) , ... June 24, 2016 , ... While ... machines such as the Cary 5000 and the 6000i models are higher end machines ... is the height of the spectrophotometer’s light beam from the bottom of the cuvette ...
(Date:6/23/2016)... ... 23, 2016 , ... Mosio, a leader in clinical research ... Recruitment and Retention Tips.” Partnering with experienced clinical research professionals, Mosio revisits the ... tools, and strategies for clinical researchers. , “The landscape of how patients receive ...
(Date:6/23/2016)... 2016   Boston Biomedical , an industry ... to target cancer stemness pathways, announced that its ... Drug Designation from the U.S. Food and Drug ... including gastroesophageal junction (GEJ) cancer. Napabucasin is an ... cancer stemness pathways by targeting STAT3, and is ...
(Date:6/23/2016)... A person commits a crime, and the detective ... the criminal down. An outbreak of foodborne illness ... (FDA) uses DNA evidence to track down the bacteria that ... It,s not. The FDA has increasingly used a complex, cutting-edge ... illnesses. Put as simply as possible, whole genome sequencing is ...
Breaking Biology Technology: