Navigation Links
Device protects transplanted pancreatic cells from the immune system
Date:4/9/2009

LA JOLLA, Calif., April 9, 2009Scientists at Burnham Institute for Medical Research (Burnham) and the University of California San Diego (UC San Diego) School of Medicine have demonstrated in mice that transplanted pancreatic precursor cells are protected from the immune system when encapsulated in polytetrafluorethylene (PTFE). The study, which suggests a new approach to treating Type 1 diabetes, was published online on April 8 in the journal Transplantation.

The team of scientists showed that after transplantation, the precursor cells mature into functional beta cells that are glucose-responsive and control blood sugar levels. Additionally, the study demonstrated that using precursor cells, instead of more committed beta cells, enhanced the cell transplant's chances of success.

"The results exceeded our expectations," said Pamela Itkin-Ansari, Ph.D., assistant adjunct professor at the UC San Diego School of Medicine and Burnham. "We thought that T-cells, although unable to penetrate the device, would cluster around it. But we found no evidence of an active immune response, suggesting that the cells in the device were invisible to the immune system."

The investigators used two different mouse models in the study. The team transplanted mouse islet cells into other mice to demonstrate that the cells were protected from the immune system when encapsulated in PTFE. Human cells encased in PTFE were then transplanted into immunodeficient mice to study the viability and function of both mature beta cells and precursor cells inside the device. Itkin-Ansari's team found that by using precursor cells that had not completely differentiated, the transplanted cells could regenerate into fully functional beta cells. This has important implications for how stem cell-derived tissue should be transplanted in the future.

Type 1 diabetes results from an autoimmune response wherein the body attacks and kills insulin producing beta cells
'/>"/>

Contact: Josh Baxt
jbaxt@burnham.org
858-795-5236
Burnham Institute
Source:Eurekalert

1

GOOD

Page: 1 2

Related biology news :

1. Device helps patients survive, regain function til transplant
2. Researchers developing device to predict proper light exposure for human health
3. IGERT fellows to design biodevices using flexible electronics
4. MIT aids creation of neural prosthetic devices
5. Atmospheric measuring device for understanding smog formation
6. EMD Serono launches easypod, new electronic growth hormone injection device
7. Better protection for biomedial devices could result from Rutgers-Camden research
8. Device prevents potential errors in childrens medications
9. Stanford researchers publish review of US medical device regulation
10. Silex Introduces Worlds First Wireless USB Device Server With Streaming Video and Audio Data Transfer
11. Portable device quickly detects early Alzheimers

Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/2/2009)...e University of Georgia College of Veterinary Medi... could open new avenues for treating Ichthyophthir...lled protozoan parasite that commonly attacks fres...encing, researchers found that Ich harbors two app...ides, which are usually found free-living, and Ric...
(Date:12/2/2009)...fit have a higher IQ and are more likely to go on ...ut at the Sahlgrenska Academy and Sahlgrenska Univ...day in the prestigious Proceedings of the Nationa...d 1.2 million Swedish men doing military service w...roup analysed the results of both physical and IQ ...
(Date:12/2/2009)...smokeless tobacco product called moist snuff plac...esota to urge the tobacco industry to change manuf...rcinogens. Their study is published online in ACS,.... It reports that this category of tobacco product...ic and cancer-causing substances. Called polycycli...
Breaking Biology News(10 mins):UGA researchers lead team in discovery involving devastating freshwater fish parasite, 'Ich' 2UGA researchers lead team in discovery involving devastating freshwater fish parasite, 'Ich' 3Young adults who exercise get higher IQ 2DaVita Named to List of Best Places to Work in Los Angeles by the Los Angeles Business Journal 48596 1DaVita Named to List of Best Places to Work in Los Angeles by the Los Angeles Business Journal 48596 2ClearTrial Industry Expert to Lead Session at DIA Annual Meeting on Improving Accrual and Contract Management in Clinical Trials 12584 1ClearTrial Industry Expert to Lead Session at DIA Annual Meeting on Improving Accrual and Contract Management in Clinical Trials 12584 2WHO Readies to Declare Swine Flu Pandemic 48590 1WHO Readies to Declare Swine Flu Pandemic 48590 2WHO Readies to Declare Swine Flu Pandemic 48590 3WHO Readies to Declare Swine Flu Pandemic 48590 4WHO Readies to Declare Swine Flu Pandemic 48590 5WHO Readies to Declare Swine Flu Pandemic 48590 6WHO Readies to Declare Swine Flu Pandemic 48590 7WHO Readies to Declare Swine Flu Pandemic 48590 8WHO Readies to Declare Swine Flu Pandemic 48590 9WHO Readies to Declare Swine Flu Pandemic 48590 10WHO Readies to Declare Swine Flu Pandemic 48590 11
...er field in Canada,s High Arctic may help research... and provide insights for future exploration of ou...ty of Calgary,s Arctic Institute of North America ... spring on the surface of an ice field not far fro...red by Institute Executive Director Dr. Benoit Bea...
...nter, Chicago, and Ceregene Inc., San Diego, have ...unction and stop the anatomic, cellular changes th...isease (HD). This is the first study to demonstrat...might be prevented in HD mice with this treatment....ceedings of the National Academy of Sciences of th...
... effect on some of the world,s finest coral reefs ... to show the long-term impact of sea temperature r...ections of coral reefs and much of the marine life...nternational team of researchers, who surveyed 21 ... in the inner islands of the Seychelles in 1994 an...
Other Biology News:Arctic expedition will investigate alien-like glacier 2Gene therapy injected into the brains' of mice with Huntington's disease 2Gene therapy injected into the brains' of mice with Huntington's disease 3Gene therapy injected into the brains' of mice with Huntington's disease 4Global warming may have damaged coral reefs forever 2
(Date:12/2/2009).... 2 /PRNewswire-Asia/ -- Simcere Pharmaceutical Gr... leading pharmaceutical company,specializing in th...nded,generic and proprietary pharmaceuticals in Ch...en included in China,s National Drug Reimbursement...ry of Human Resources and Social,Security on Novem...
(Date:12/1/2009)...lomon announced that he has joined Carolina Eyecar...te at www.DrKerrySolomon.com , which was develope...roven LASIK, lens implant, and cataract surgery ex...s substantial contributions to improving vision co... Surgeons, which screens LASIK surgeons based upon...
(Date:12/1/2009)...RNewswire/ -- Harvest Technologies Corp. ( www.har...mpany sponsored 60-patient clinical trial conducte...dia using the company,s BMAC System to treat patie...a (CLI). Sri Ramachandra Medical Center is a Harva...sed in Chennai, India and one of the largest priva...
(Date:12/1/2009)... 1 Prairie Heart Institute of Illi...ntly awarded two statuettes at the first-ever CLIO...ty. The CLIO Healthcare Awards recognizes creative...tising industry and is an extension of the CLIO Aw...mpetitions for advertising, design and interactive...
Breaking Biology Technology:Simcere Announces 105 Drugs Included in China's National Drug Reimbursement List 2Simcere Announces 105 Drugs Included in China's National Drug Reimbursement List 3Charleston LASIK and Cataract Expert Dr. Kerry Solomon Opens New Practice and Launches DrKerrySolomon.com 2Charleston LASIK and Cataract Expert Dr. Kerry Solomon Opens New Practice and Launches DrKerrySolomon.com 3Charleston LASIK and Cataract Expert Dr. Kerry Solomon Opens New Practice and Launches DrKerrySolomon.com 4Charleston LASIK and Cataract Expert Dr. Kerry Solomon Opens New Practice and Launches DrKerrySolomon.com 5Charleston LASIK and Cataract Expert Dr. Kerry Solomon Opens New Practice and Launches DrKerrySolomon.com 6Harvest Technologies Announces Trial Results in its India Study Using BMAC to Treat Patients With Non-Reconstructable Critical Limb Ischemia 2Harvest Technologies Announces Trial Results in its India Study Using BMAC to Treat Patients With Non-Reconstructable Critical Limb Ischemia 3Prairie Heart Institute of Illinois Wins Two CLIO Healthcare Awards 2
...tions, such as this barrel spring, are old enough ...r produced. Over the past decade, the economy has...ortance of intangible assets, such as patents. A p...d business method or a killer app software tool to...ical industry can form the basis for an entire bus...
...studies stem cells in his Primate Center lab. Phot... Madison, Wis. James Thomson avoided talking...esidential election, explaining instead the scienc... a scientific celebrity on the University of Wisco...ng human embryonic stem cells, packed an auditoriu...
...vity and communications tools now ubiquitous, orga...potential to promote more effective communication ...apabilities have an important role in organization...d to modify the culture and behavior of an organiz...ure, is naive. Yet that is precisely what some exe...
Other Biology Technology:Patent essentials for business owners: from patent to profit 2Patent essentials for business owners: from patent to profit 3Patent essentials for business owners: from patent to profit 4Patent essentials for business owners: from patent to profit 5James Thomson plans to stay in Madison to study genesis of stem cells 2James Thomson plans to stay in Madison to study genesis of stem cells 3Dont rely on information technology to change corporate culture 2Dont rely on information technology to change corporate culture 3
...amer screening and binding optimization and built ...on-chip synthesis platform. These microarrays are ...amer Microarray Service. Probe Content Our Stan...han 1500 known aptamer sequences. Add up to 100 of...
...sive service for custom peptide microarray experim...nthesized on Paraflo microfluidic chips for quanti...s or serum samples. This comprehensive service inc...ng assays using sample(s) provided by you, single ...
...amer screening and binding optimization and built ...on-chip synthesis platform. Thousands of customer ... LC Sciences can provide assistance with custom se...part of our comprehensive DNA/RNA Aptamer Microarr...
...nsferase (GST) is commonly used as a fusion partne...Tag sequence has been reported to enhance the prod...ion partners. When expressed in a soluble, properl...ied with immobilized glutathione. Gentle elution i...
Biology Products: