Navigation Links
Device protects transplanted pancreatic cells from the immune system
Date:4/9/2009

LA JOLLA, Calif., April 9, 2009Scientists at Burnham Institute for Medical Research (Burnham) and the University of California San Diego (UC San Diego) School of Medicine have demonstrated in mice that transplanted pancreatic precursor cells are protected from the immune system when encapsulated in polytetrafluorethylene (PTFE). The study, which suggests a new approach to treating Type 1 diabetes, was published online on April 8 in the journal Transplantation.

The team of scientists showed that after transplantation, the precursor cells mature into functional beta cells that are glucose-responsive and control blood sugar levels. Additionally, the study demonstrated that using precursor cells, instead of more committed beta cells, enhanced the cell transplant's chances of success.

"The results exceeded our expectations," said Pamela Itkin-Ansari, Ph.D., assistant adjunct professor at the UC San Diego School of Medicine and Burnham. "We thought that T-cells, although unable to penetrate the device, would cluster around it. But we found no evidence of an active immune response, suggesting that the cells in the device were invisible to the immune system."

The investigators used two different mouse models in the study. The team transplanted mouse islet cells into other mice to demonstrate that the cells were protected from the immune system when encapsulated in PTFE. Human cells encased in PTFE were then transplanted into immunodeficient mice to study the viability and function of both mature beta cells and precursor cells inside the device. Itkin-Ansari's team found that by using precursor cells that had not completely differentiated, the transplanted cells could regenerate into fully functional beta cells. This has important implications for how stem cell-derived tissue should be transplanted in the future.

Type 1 diabetes results from an autoimmune response wherein the body attacks and kills insulin producing beta cells in the pancreas. One of the challenges of cell transplantation therapy to treat diabetes is the need for long term immunosuppression, which carries health risks. Transplanting beta cells in a protective device could alleviate the need to use immunosuppressive drugs.


'/>"/>

Contact: Josh Baxt
jbaxt@burnham.org
858-795-5236
Burnham Institute
Source:Eurekalert

Related biology news :

1. Device helps patients survive, regain function til transplant
2. Researchers developing device to predict proper light exposure for human health
3. IGERT fellows to design biodevices using flexible electronics
4. MIT aids creation of neural prosthetic devices
5. Atmospheric measuring device for understanding smog formation
6. EMD Serono launches easypod, new electronic growth hormone injection device
7. Better protection for biomedial devices could result from Rutgers-Camden research
8. Device prevents potential errors in childrens medications
9. Stanford researchers publish review of US medical device regulation
10. Silex Introduces Worlds First Wireless USB Device Server With Streaming Video and Audio Data Transfer
11. Portable device quickly detects early Alzheimers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/26/2016)... BANGALORE, India and LONDON ... Infosys Finacle, part of EdgeVerve Systems, a ... ), and Onegini today announced a partnership to ... banking solutions.      (Logo: http://photos.prnewswire.com/prnh/20151104/283829LOGO ... banks to provide their customers enhanced security to ...
(Date:4/15/2016)... 2016  A new partnership announced today will ... decisions in a fraction of the time it ... high-value life insurance policies to consumers without requiring ... Force Diagnostics, rapid testing (A1C, Cotinine and HIV) ... pressure, weight, pulse, BMI, and activity data) available ...
(Date:4/13/2016)... 13, 2016  IMPOWER physicians supporting Medicaid patients in ... new clinical standard in telehealth thanks to a new ... higi platform, IMPOWER patients can routinely track key health ... mass index, and, when they opt in, share them ... to a local retail location at no cost. By ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... , June 23, 2016 Houston ... with the Cy-Fair Sports Association to serve as ... the agreement, Houston Methodist Willowbrook will provide sponsorship ... and connectivity with association coaches, volunteers, athletes and ... with the Cy-Fair Sports Association and to bring ...
(Date:6/23/2016)... 2016  The Biodesign Challenge (BDC), a university competition ... harness living systems and biotechnology, announced its winning teams ... New York City . The ... projects at MoMA,s Celeste Bartos Theater during the daylong ... senior curator of architecture and design, and Suzanne ...
(Date:6/23/2016)... (PRWEB) , ... June 23, 2016 , ... STACS DNA ... Technical Leader at the Arkansas State Crime Laboratory, has joined STACS DNA as a ... STACS DNA team,” said Jocelyn Tremblay, President and COO of STACS DNA. “In further ...
(Date:6/23/2016)... 23, 2016  Blueprint Bio, a company dedicated to ... medical community, has closed its Series A funding round, ... "We have received a commitment from Forentis ... need to meet our current goals," stated Matthew ... runway to complete validation on the current projects in ...
Breaking Biology Technology: