Navigation Links
Device could improve harvest of stem cells from umbilical cord blood
Date:6/20/2011

Johns Hopkins graduate students have invented a system to significantly boost the number of stem cells collected from a newborn's umbilical cord and placenta, so that many more patients with leukemia, lymphoma and other blood disorders can be treated with these valuable cells.

The prototype is still in the testing stage, but initial results are promising. The student inventors have obtained a provisional patent covering the technology and have formed a company, TheraCord LLC, to further develop the technology, which may someday be used widely in hospital maternity units. The students say the need for this system is obvious.

"Cord blood, collected from the umbilical cord and placenta after live birth, is the most viable source of stem cells, yet over 90 percent is uncollected and discarded," the team members wrote in a presentation of their project at the university's recent Biomedical Engineering Design Day. "One of the main reasons valuable cord blood is so frequently discarded is because no adequate collection method exists."

The students say their easy-to-use invention, called the CBx System, could remedy these shortcomings.

When a baby is born, a few families pay for private collection and storage of the child's cord blood, in case its stem cells are needed to treat a future illness. When families do not choose this option, the materials containing cord blood are generally thrown away as medical waste. But at the 180 hospitals affiliated with public cord blood banks, new mothers can donate cord blood so that its stem cells can be extracted and used to rebuild the immune systems of seriously ill patients, particularly those with blood cancers such as leukemia, lymphoma and myeloma.

According to the Johns Hopkins students, the current method of collecting these cells from cord blood doesn't work well because it relies strictly on gravity. The National Marrow Donor Program says about 50 percent of the units collected in this way contain enough stem cells to be stored for transplant use. Another organization, the National Cord Blood Program, says only 40 percent of collected units meet transplantation standards. Even when the procedure is successful, the Johns Hopkins students said, the average collection yields only enough stem cells to treat a child but not enough to treat an adult patient, based on the recommended cell dosage.

To solve these problems, the students, who were enrolled in a master's degree program in the university's Center for Bioengineering Innovation and Design, spent the past year developing a new collection method that uses both mechanical forces and a chemical solution to help detach and flush more stem cells from the cord and placenta blood vessels.

"This is important for two reasons," said James Waring, a member of the student team. "First, we believe it collects enough cells from each birth so that stem-cell therapy can be used on adult patients, who need more cells."

In addition, in early testing on discarded cords and placentas at The Johns Hopkins Hospital, the team's device collected up to 50 percent more stem cells than the traditional gravity system, the students said.

"We think our system will increase the number of successful cord blood collections, meaning more patients overall will benefit," Waring said.

Along with Waring, the student inventors were Elias Bitar, Chris Chiang, Matthew Means and Sean Monagle. While developing the system, the team entered its project in college business plan competitions, gathering recognition from judges and about $14,000 in prize money. After completing their academic program, the students recently received their master's degrees. Team members Chiang and Means have chosen to remain in Baltimore to manage and advance TheraCord over the coming year.

"Our next step," said Chiang, "is to optimize the system so that it collects even more stem cells. Based on previous experiments using similar techniques, we believe it's possible to get two to five times the amount produced by the existing gravity technique. The other important goal is to make the system as easy as possible for hospital employees to use."

The students learned about the need for a better way to collect stem cells early in their master's program, when they accompanied physicians on hospital rounds to learn what new medical tools and devices were needed most urgently.

Edith Gurewitsch, a Johns Hopkins School of Medicine associate professor of gynecology/obstetrics and biomedical engineering, first identified the clinical need for a better method to collect cord blood. Agreeing to be the student team's clinical advisor, she provided guidance on both the clinical and workflow aspects of the device's design. In the patent documents, Gurewitsch is listed as a co-inventor of the CBx System technology.


'/>"/>

Contact: Phil Sneiderman
prs@jhu.edu
443-287-9960
Johns Hopkins University
Source:Eurekalert  

Related biology news :

1. U.S. Biomedical Leaders Present a New National Device Innovation Strategy Based on "Value-driven Engineering"
2. Single GFP-expressing cell is basis of living laser device
3. Stamping out low cost nanodevices
4. Noninvasive wireless near-infrared device provides reliable diagnosis of bladder dysfunction
5. MaxID Lands Sale of 1000 iDL500 Multi-Modal Handheld Identity Devices in South Africa
6. New device promises safer way to deliver powerful drugs
7. University of Nevada, Reno invents next-gen device to track worlds air quality
8. MIT: New blood-testing device can quickly spot cancer cells, HIV
9. New device uses submarine technology to diagnose stroke quickly
10. UCLA Engineering advance with new nanomaterials good news for next-generation electronic devices
11. University of South Florida and Draper team to create advanced devices for testing malaria drugs
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Device could improve harvest of stem cells from umbilical cord blood
(Date:11/29/2016)... , Nov. 29, 2016   Neurotechnology ... and object recognition technologies, today released FingerCell ... fingerprint recognition solutions that run on low-power, ... template using less than 128KB of memory, ... devices that have limited on-board resources, such ...
(Date:11/22/2016)... According to the new market research report "Biometric System Market by ... Component (Hardware and Software), Function (Contact and Non-contact), Application, and Region - ... grow from USD 10.74 Billion in 2015 to reach USD 32.73 Billion ... Continue Reading ... ...
(Date:11/17/2016)... Market Watch: Primarily supported by ownership types; Private ... market is to witness a value of US$37.1 billion by ... Annual Growth Rate (CAGR) of 10.75% is foreseen from ... North America is not way behind ... at 9.56% respectively. Report Focus: The ...
Breaking Biology News(10 mins):
(Date:11/30/2016)... 2016 /PRNewswire/ -  Equicare Health Inc ., the leading ... as one of the top 100 companies in the ... that distinguishes the top digital health companies across the ... forward this year continually upgrading our product with the ... and team," says Len Grenier , CEO of ...
(Date:11/30/2016)... BEIJING , Nov. 30, 2016 Novogene ... services and solutions with cutting edge next-generation sequencing (NGS) ... a USD $75 Million [515 Million RMB] B round ... Capital Management ( Shenzhen ) Co., Ltd. ... Innovation") and Shanghai Sigma Square Investment Center LP ("Sigma ...
(Date:11/30/2016)... GREENWICH, Connecticut , November 30, 2016 ...   ... Aptuit, LLC today announced ... screening library. An additional 150,000 novel compounds have increased the ... selected to broaden the hit discovery capabilities of the company. ...
(Date:11/30/2016)... (PRWEB) , ... November 30, 2016 , ... SSCI, the ... to discuss the implications of the latest FDA guidance on pharmaceutical cocrystals as ... 2016 in Cambridge, MA. , The event follows the successful November 15th ...
Breaking Biology Technology: