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Developmental neurobiology: How the brain folds to fit
Date:4/26/2013

ion and folding

"Trnp1 is critical for the expansion and folding of the cerebral cortex, and its expression level is dynamically controlled during development," says Gtz. In the early embryo, Trnp1 is locally expressed in high concentrations. This promotes the proliferation of self-renewing multipotent neural stem cells and supports tangential expansion of the cerebral cortex. The subsequent fall in levels of Trnp1 is associated with an increase in the numbers of various intermediate progenitors and basal radial glial cells. This results in the ordered formation and migration of a much enlarged number of neurons forming folds in the growing cortex.

The findings are particularly striking because they imply that the same molecule Trnp1 controls both the expansion and the folding of the cerebral cortex and is even sufficient to induce folding in a normally smooth cerebral cortex. Trnp1 therefore serves as an ideal starting point from which to dissect the complex network of cellular and molecular interactions that underpin the whole process. Gtz and her colleagues are now embarking on the next step in this exciting journey - determination of the molecular function of this novel nuclear protein Trnp1 and how it is regulated.


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Contact: Luise Dirscherl
dirscherl@lmu.de
0049-892-180-2706
Ludwig-Maximilians-Universitt Mnchen
Source:Eurekalert

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