Navigation Links
Developmental neurobiology: How the brain folds to fit
Date:4/26/2013

During fetal development of the mammalian brain, the cerebral cortex undergoes a marked expansion in surface area in some species, which is accommodated by folding of the tissue in species with most expanded neuron numbers and surface area. Researchers have now identified a key regulator of this crucial process.

Different regions of the mammalian brain are devoted to the performance of specific tasks. This in turn imposes particular demands on their development and structural organization. In the vertebrate forebrain, for instance, the cerebral cortex which is responsible for cognitive functions is remarkably expanded and extensively folded exclusively in mammalian species. The greater the degree of folding and the more furrows present, the larger is the surface area available for reception and processing of neural information. In humans, the exterior of the developing brain remains smooth until about the sixth month of gestation. Only then do superficial folds begin to appear and ultimately dominate the entire brain in humans. Conversely mice, for example, have a much smaller and smooth cerebral cortex.

"The mechanisms that control the expansion and folding of the brain during fetal development have so far been mysterious," says Professor Magdalena Gtz, a professor at the Institute of Physiology at LMU and Director of the Institute for Stem Cell Research at the Helmholtz Center Munich. Gtz and her team have now pinpointed a major player involved in the molecular process that drives cortical expansion in the mouse. They were able to show that a novel nuclear protein called Trnp1 triggers the enormous increase in the numbers of nerve cells which forces the cortex to undergo a complex series of folds. Indeed, although the normal mouse brain has a smooth appearance, dynamic regulation of Trnp1 results in activating all necessary processes for the formation of a much enlarged and folded cerebral cortex.

Levels of Trnp1 control expansion and folding

"Trnp1 is critical for the expansion and folding of the cerebral cortex, and its expression level is dynamically controlled during development," says Gtz. In the early embryo, Trnp1 is locally expressed in high concentrations. This promotes the proliferation of self-renewing multipotent neural stem cells and supports tangential expansion of the cerebral cortex. The subsequent fall in levels of Trnp1 is associated with an increase in the numbers of various intermediate progenitors and basal radial glial cells. This results in the ordered formation and migration of a much enlarged number of neurons forming folds in the growing cortex.

The findings are particularly striking because they imply that the same molecule Trnp1 controls both the expansion and the folding of the cerebral cortex and is even sufficient to induce folding in a normally smooth cerebral cortex. Trnp1 therefore serves as an ideal starting point from which to dissect the complex network of cellular and molecular interactions that underpin the whole process. Gtz and her colleagues are now embarking on the next step in this exciting journey - determination of the molecular function of this novel nuclear protein Trnp1 and how it is regulated.


'/>"/>

Contact: Luise Dirscherl
dirscherl@lmu.de
0049-892-180-2706
Ludwig-Maximilians-Universitt Mnchen
Source:Eurekalert

Related biology news :

1. New genes contributing to autism and related neurodevelopmental disorders uncovered
2. Mice with big brains provide insight into brain regeneration and developmental disorders
3. MARC travel awards announced for the Society for Developmental Biology 71st Annual Meeting
4. Environmental estrogens affect early developmental activity in zebrafish
5. Distinct developmental patterns identified in children with autism during their first 3 years
6. Developmental bait and switch
7. Researchers find new genetic pathway behind neurodevelopmental disorders
8. Developmental biologist Arthur Lander named Donald Bren Professor
9. Researchers explain a key developmental mechanism for the first time in plants
10. UTSW molecular biologist Olson wins March of Dimes developmental biology prize
11. Developmental delays in children following prolonged seizures
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/30/2017)... KONG , March 30, 2017 The ... a system for three-dimensional (3D) fingerprint identification by adopting ground breaking ... into a new realm of speed and accuracy for use in ... at an affordable cost. ... ...
(Date:3/28/2017)... -- The report "Video Surveillance Market by ... Devices), Software (Video Analytics, VMS), and Service (VSaaS, Installation ... 2022", published by MarketsandMarkets, the market was valued at ... reach USD 75.64 Billion by 2022, at a CAGR ... considered for the study is 2016 and the forecast ...
(Date:3/24/2017)... Research and Markets has announced the addition of the ... Industry Forecast to 2025" report to their offering. ... The Global Biometric Vehicle Access ... 15.1% over the next decade to reach approximately $1,580 million by ... and forecasts for all the given segments on global as well ...
Breaking Biology News(10 mins):
(Date:8/15/2017)... San Diego, CA (PRWEB) , ... August 15, ... ... science company pioneering graphene biosensors that accelerate pharmaceutical and biotherapeutics development, announces the ... reduces the number of steps needed to gain kinetic binding data for a ...
(Date:8/15/2017)... Linda, Ca (PRWEB) , ... August 15, 2017 ... ... coffee production and is threatened by various biotic and abiotic factors. During this ... complex evolutionary history of coffee, as well as gain a better understanding of ...
(Date:8/11/2017)... Aug. 11, 2017  Market researcher Kalorama ... Times article regarding the telemedicine market.  The ... Kalorama Information.  The article, "Heart and ...  used information from Kalorama Information,s Remote ... Telemedicine Market  (Sleep, Diabetes, Vital Signs ...
(Date:8/10/2017)... ... August 09, 2017 , ... Teachers ... as students. From August 14th through the 16th, the University City Science Center ... the summer of 2016, provides Philadelphia-based middle school educators an opportunity for professional ...
Breaking Biology Technology: