Navigation Links
Developmental gene-environment interactions: A model for psychosis
Date:8/29/2010

The incidence of psychotic disorders varies greatly across places and demographic groups, as do symptoms, course, and treatment response across individuals. High rates of schizophrenia in large cities, and among immigrants, cannabis users, and traumatised individuals reflect the causal influence of environmental exposures. This, in combination with progress in the area of molecular genetics, has generated interest in more complicated models of schizophrenia aetiology that explicitly posit gene-environment interactions.

Unravelling the causes of psychotic disorders

Schizophrenia and related psychotic disorders have a complex aetiology. Research has attempted to determine the role of specific biological variables, such as genetic and biochemical factors and subtle changes in brain morphology. Genetic vulnerability in schizophrenia is shared in part with bipolar disorder and recent molecular genetic findings also indicate an overlap with developmental disorders such as autism (Van Os & Kapur, 2009). According to twin and family studies more than half of the vulnerability for schizophrenia is of genetic origin. However, attempts to discover genes that relate directly to psychotic disorder have been frustrating and often disappointing, and despite enormous investments, the identification of actual molecular genetic variants underlying schizophrenia liability has proven extremely difficult. This difficulty is mainly due to the phenomenon of gene-environment interaction, which is defined as genetic control of sensitivity to the environment.

Exciting findings in other areas of psychiatry have motivated researchers to turn their attention to better understanding the complex ways in which genetic factors interact with non-genetic factors to produce psychosis. Biological vulnerability factors with a genetic background interact with complex physical, psychological and environmental vulnerability factors. Conceptualised in a model, gene-e
'/>"/>

Contact: Sonja Mak
s.mak@update.europe.at
431-405-5734
European College of Neuropsychopharmacology
Source:Eurekalert

Page: 1 2 3 4 5 6

Related biology news :

1. Digital zebrafish embryo provides the first complete developmental blueprint of a vertebrate
2. Carnegies Donald Brown receives lifetime achievement award from Society for Developmental Biology
3. Mouse model provides a new tool for investigators of human developmental disorder
4. Specific genetic cause of fetal alcohol-related developmental disorders found
5. Genetic marker linked to problem behaviors in adults with developmental disabilities
6. Developmental delay could stem from nicotinic receptor deletion
7. Chinese scientists discover marker indicating the developmental potential of stem cells
8. Tufts wins NCRR grant for Collaborative Cluster in Genome Structure and Developmental Patterning
9. Developmental problems: Some exist in the genes
10. Fertilizer chemicals linked to animal developmental woes
11. Penn biophysicists create new model for protein-cholesterol interactions in brain and muscle tissue
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/15/2014)... German Gauß-Allianz has admitted Johannes Gutenberg University Mainz ... Rhineland-Palatinate science hub continues to maintain a significant ... , "The acceptance of Johannes Gutenberg University ... is a milestone in the national and international ... The state of Rhineland-Palatinate can be proud that ...
(Date:10/15/2014)... will be awarded the 44th Rosenstiel Award for Distinguished ... pioneering research exploring the mechanisms of genomic instability and ... Alt is the second alumnus to win the Rosenstiel ... in 2003. , Alt is the Charles A. Janeway ... Medical School and an investigator at the Howard Hughes ...
(Date:10/14/2014)... Ohio (Oct. 14, 2014)—It,s been millions of years since ... a team led by Ohio University scientists is breathing ... model airflow through dinosaur snouts. The research has important ... only breathe but to enhance the sense of smell ... ,nosy, animals," said Ohio University doctoral student Jason Bourke, ...
Breaking Biology News(10 mins):Johannes Gutenberg University Mainz joins Germany's Gauss-Allianz as a full member 2Johannes Gutenberg University Mainz joins Germany's Gauss-Allianz as a full member 3Brandeis awards 44th Rosenstiel Award to pioneering geneticist Fred Alt 2Dinosaur breathing study shows that noses enhanced smelling and cooled brain 2Dinosaur breathing study shows that noses enhanced smelling and cooled brain 3
... novel technology for synthesising chemicals from plant material could produce ... scientists. But only if the infrastructure is set up in ... issue of Biofuels, Bioproducts & Biorefining . Developed ... novel technology is known as bioliq, and is able to ...
... N.J. In a paper published in the journal ... and a team of international collaborators have described the genome ... day help researchers to produce better food crops for arid ... Messing, director of ...
... Lincoln Park Zoo has been awarded a grant ... division, the Urban Wildlife Institute, which will focus studies ... utilize sound science to create best practice conflict resolution. ... with epidemiology research to create a holistic approach to ...
Cached Biology News:Novel technology could produce biofuel for around €0.50 a liter ($2.49 a gallon) 2Sequencing of sorghum genome completed 2Lincoln Park Zoo awarded $1.5 million grant for new research institute 2
(Date:10/25/2014)... 24, 2014 SonaCare Medical, LLC, ... (HIFU) technology, announced that its Board of Directors ... Executive Officer, President and member of the Board ... will take-on expanded responsibilities within the company, including ... as overseeing commercialization, manufacturing and finance. , ...
(Date:10/25/2014)... YORK , Oct. 24, 2014 ... Inc. (ACCP), a biopharmaceutical company advancing patient care ... 1-for-50 reverse split of its common stock effective ... 24, 2014. PlasmaTech,s common stock will trade on ... and temporary ticker symbol "ACCPD". After 20 days, ...
(Date:10/25/2014)... , October 24, 2014 ... Markets ( http://www.researchandmarkets.com/research/t5t5pd/the_global_market ) has announced the addition ... Nanotubes, Graphene And Other 2-D Nanomaterials " ... (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , ,CNTs and graphene are ... known to man, with a performance-per-weight greater ...
(Date:10/22/2014)... October 21, 2014 The Americas ... inorganic refrigerants market in Americas with analysis and ... of the Americas Inorganic Refrigerants Market report, to ... This also provides a glimpse of the segmentation ... supported by various tables and figures. , ...
Breaking Biology Technology:SonaCare Medical Board of Directors Appoints Dr. Mark Carol as CEO and President 2SonaCare Medical Board of Directors Appoints Dr. Mark Carol as CEO and President 3PlasmaTech Biopharmaceuticals, Inc. Announces Reverse Stock Split, Ticker Change and Launches New Corporate Website 2The Global Market for Carbon Nanotubes, Graphene and Other 2-D Nanomaterials 2The Global Market for Carbon Nanotubes, Graphene and Other 2-D Nanomaterials 3The Global Market for Carbon Nanotubes, Graphene and Other 2-D Nanomaterials 4The Americas Inorganic Refrigerants Market is estimated to grow to $71.6 million by 2018 - New Report by MicroMarket Monitor 2The Americas Inorganic Refrigerants Market is estimated to grow to $71.6 million by 2018 - New Report by MicroMarket Monitor 3
... Therapeutics (Nasdaq: NKTR ) will announce its financial results ... November 4, 2009, after the close of U.S.-based financial markets. ... conference call to review the results beginning at 5:00 p.m. ... press release and a live audio-only Webcast of the conference ...
... YORK, Oct. 29 Reportlinker.com announces ... is available in its catalogue. , ... and Rapidly Broadening Market ... , Molecular diagnostic applications in the ...
... Dendreon Corporation (Nasdaq: DNDN ) today announced that management will present ... Summit 2009, New York City, Tuesday, November ... 2009 Healthcare Conference, Phoenix, Arizona, Friday, November ... Markets 6th Annual Healthcare Conference, New York City, ...
Cached Biology Technology:Nektar to Announce Financial Results for the Third Quarter of 2009 on Wednesday, November 4, 2009, After Close of U.S.-Based Financial Markets 2Reportlinker Adds Molecular Diagnostics: A Dynamic and Rapidly Broadening Market 2Reportlinker Adds Molecular Diagnostics: A Dynamic and Rapidly Broadening Market 3Reportlinker Adds Molecular Diagnostics: A Dynamic and Rapidly Broadening Market 4Reportlinker Adds Molecular Diagnostics: A Dynamic and Rapidly Broadening Market 5Reportlinker Adds Molecular Diagnostics: A Dynamic and Rapidly Broadening Market 6
Request Info...
When added to StemSep T Cell Enrichment cocktail, human TCRab TAC is designed to deplete human TCRab from samples to isolate gd T cells....
When added to either StemSep CD4+ or CD8+ T Cell Enrichment cocktails, human CD69 TAC is designed to deplete human CD69 from samples to isolate resting CD4+ or CD8+ T cells....
When added to either StemSep CD4+ or CD8+ T Cell Enrichment cocktails, human CD45RA TAC is designed to deplete human CD45RA from samples to isolate memory CD4+ or CD8+ T cells....
Biology Products: