Navigation Links
Developmental delays in children following prolonged seizures
Date:4/7/2013

Researchers from the UK determined that developmental delays are present in children within six weeks following convulsive status epilepticus (CSE)a seizure lasting longer than thirty minutes. The study appearing today in Epilepsia, a journal published by Wiley on behalf of the International League Against Epilepsy (ILAE), suggests that neurodevelopmental impairments continue to be present one year after CSE.

CSE is one of the most common neurological emergencies in children. These prolonged seizures can occur with or without fevers (febrile). Studies show that CSE occurs more frequently during the first three years of lifea time of critical growth and development in children. Prior research investigating CSE has focused mainly on simple febrile seizures and was conducted years after the event occurred.

"Our study is the first to examine cognitive, language, and motor function in children within six weeks of CSE, with follow-up at one year to determine their developmental track," said lead author, Dr. Marina Martinos with the Developmental Cognitive Neurosciences Unit at UCL Institute of Child Health in London. "Understanding how CSE impacts early childhood development and whether this type of seizure has long-term adverse affects is an important addition to medical evidence."

For the present study, researchers recruited 54 children between one and forty-two months of age who had at least one CSE event. CSE episodes were classified as prolonged febrile seizures (PFS) or nonfebrile CSE. All pediatric participants underwent neuropsychological assessments and imaging scans within six weeks of the CSE event and at one year. Developmental skills were measured in children who had seizures and compared to children without seizures with normal development.

Half of the pediatric participants had PFS and the other half had nonfebrile CSE, with assessments carried out at a mean of 38 days following CSE. Findings indicate that CSE is linked to developmental impairments within six weeks of the event, and that the impairments persisted at the one-year follow-up. Children with nonfebrile PFS had worse developmental outcomes than those with PFS, and children in the PFS group had poorer developmental skills than those in the control group. The authors found that seizure characteristics (e.g. duration) were not a significant predictor of developmental performance.

Dr. Martinos concludes, "We found developmental impairments in children following CSE, including those with PFS who normally do not display neurologic issues prior to the seizure. The fact that neurodevelopmental impairments are still present at one year after the episode suggests that the CSE event is not having just a transient effect on developmental abilities. The CSE may have a longer lasting impact on future development through a more permanent reorganization of functional brain networks a reorganization that may have already taken place when we first assess these children."

Alternatively, the authors comment, these data suggest that the neurodevelopmental impairments observed predate the seizure even in those with no neurological priors. The authors propose that further studies that include neurocognitive techniques are necessary to enhance understanding of the long-term impact of CSE on child development.


'/>"/>

Contact: Dawn Peters
sciencenewsroom@wiley.com
781-388-8408
Wiley
Source:Eurekalert

Related biology news :

1. New genes contributing to autism and related neurodevelopmental disorders uncovered
2. Mice with big brains provide insight into brain regeneration and developmental disorders
3. MARC travel awards announced for the Society for Developmental Biology 71st Annual Meeting
4. Environmental estrogens affect early developmental activity in zebrafish
5. Distinct developmental patterns identified in children with autism during their first 3 years
6. Developmental bait and switch
7. Researchers find new genetic pathway behind neurodevelopmental disorders
8. Developmental biologist Arthur Lander named Donald Bren Professor
9. Researchers explain a key developmental mechanism for the first time in plants
10. UTSW molecular biologist Olson wins March of Dimes developmental biology prize
11. Drought in the Horn of Africa delays migrating birds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/28/2017)... March 28, 2017 The report ... (Camera, Monitors, Servers, Storage Devices), Software (Video Analytics, VMS), ... - Global Forecast to 2022", published by MarketsandMarkets, the ... and is projected to reach USD 75.64 Billion by ... 2022. The base year considered for the study is ...
(Date:3/24/2017)... -- Research and Markets has announced the addition of ... - Industry Forecast to 2025" report to their offering. ... The Global Biometric Vehicle ... around 15.1% over the next decade to reach approximately $1,580 million ... estimates and forecasts for all the given segments on global as ...
(Date:3/22/2017)... Lithuania , March 21, 2017   ... and object recognition technologies, today announced the release ... kit (SDK), which provides improved facial recognition using ... cameras on a single computer. The new version ... to improve accuracy, and it utilizes a Graphing ...
Breaking Biology News(10 mins):
(Date:5/16/2017)... ... May 16, 2017 , ... ... Office (USPTO) for a wireless electrocardiogram (ECG or EKG) acquisition and monitoring device. ... integrated into clothing, or secured directly onto the skin, making them significantly easier ...
(Date:5/16/2017)... MA (PRWEB) , ... May 16, 2017 , ... On ... have an ideal audience for introducing the advance in stem cell medicine that his ... Tuesday will be the second day of the Alliance for Regenerative Medicine’s first partnering ...
(Date:5/15/2017)... ... May 15, 2017 , ... ... the clinical skincare brand has today launched its first-ever cross-medium campaign, #StandFirm, with ... shared across digital and social media channels, emphasizing Algenist’s stance on individuality and ...
(Date:5/11/2017)... 11, 2017   BioLife Solutions , Inc. (NASDAQ: ... proprietary clinical grade cell and tissue hypothermic storage ... today reported operational highlights and financial results for the first ... sales reached a new high of $2.4 million in the ... same period in 2016. Revenue growth was driven by sales ...
Breaking Biology Technology: