Navigation Links
Development of novel therapies for endothelial damage may heal atherosclerotic plaques
Date:4/21/2013

BOSTON Heart disease and approximately half of all strokes are the results of advanced atherosclerosis with damaged endothelium, the inner lining of blood vessels. In 2009, the direct and indirect annual cost of heart disease and stroke was approximately $312.6 billion. Projections are for the total cost of heart disease to increase from $523 to $1.126 billion from 2013 to 2030. And by 2030, it is expected that there will be more than 148 million of the US population would have heart disease. Development of new technologies for assessing and treating endothelium damage will help reduce that financial burden as reduce the human health burden resulting from atherosclerosis.

Dr. Hua Pan, Research Instructor in Medicine at Dr. Samuel Wickline's Laboratory in Washington University School of Medicine, investigated quantitative evaluation and developed novel therapies for endothelial barrier damage. The evolution and severity of endothelium damage in advanced atherosclerotic plaque remain unknown, in part because quantifiable methods are lacking for its in vivo assessment. Her latest study is the first to demonstrate, in a well-established atherosclerosis mouse model, ApoE deficient mice, a multifunctional perfluorocarbon (PFC) nanoparticle (NP) for quantification of endothelial damage as well as targeted anti-inflammatory drug delivery to the endothelium damage site.

The study, conducted in ApoE deficient mice, quantified endothelium damage by using PFC NP retained in mouse aorta as surrogate. It demonstrated the evolution and severity of endothelium damage in correlation to the length of the animal fat-diet consumption. Moreover, the same PFC NP loaded with anti-inflammatory drug, NF-κB inhibitor, down-regulated inflammation. Dr. Wickline noted, this finding provided a new avenue for defining disease stage and for following therapy to heal dangerous atherosclerotic plaques.

Her findings will be presented April 22, 2013 during Experimental Biology 2013 in Boston, MA.


'/>"/>

Contact: Jim Bernstein
jbernstein@aspet.org
301-646-3259
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related biology news :

1. Artificial womb unlocks secrets of early embryo development
2. REST is crucial for the timing of brain development
3. Embryonic development protein active in cancer growth
4. Scientists win $2 million to study new pathway in development and maintenance of lymphoma
5. Stomata development in plants unraveled -- a valuable discovery for environmental research
6. Promising developments in early diagnosis and treatment of mesothelioma
7. Europe meets to discuss progress in energy research and development
8. Gut microbiota transplantation may prevent development of diabetes and fatty liver disease
9. New genes contributing to autism and related neurodevelopmental disorders uncovered
10. Michael J. Fox Foundation grant to Dr. Samuel Young will provide Parkinsons drug development tools
11. Navigating the IP Minefield of Human Embryonic Stem Cell Development
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/20/2016)... A market that just keeps on growing. ... explosion in genomics knowledge. Learn all about it in ... of dynamic trends are pushing market growth and company ... pharmacogenomics - pathogen evolution - next generation sequencing - ... understanding of the role of genetic material in Disease ...
(Date:1/20/2016)... SAN JOSE, Calif. , Jan. 20, 2016 ... leading developer of human interface solutions, today announced ... touch controller solution for wearables and small screen ... appliances such as printers. Supporting round and rectangular ... the S1423 offers excellent performance with moisture on ...
(Date:1/15/2016)... , Jan. 15, 2016 Recent publicized breaches ... to find new ways to ensure data security and ... iOS and Android that ties a ... transforming it into a hardware authorization token. Customer service ... their fingerprint on their KodeKey enabled device to verify ...
Breaking Biology News(10 mins):
(Date:2/11/2016)... WASHINGTON , Feb. 11, 2016   BioInformant ... strategic report, "Stem Cell Research Products, Opportunities, Tools, and ... 2020. ... specialize in the stem cell industry, BioInformant has more ... of the stem cell market, by stem cell type. ...
(Date:2/11/2016)... ... 2016 , ... Global Stem Cells Group, has ... The new facility will provide advanced protocols and state-of-the-art techniques in cellular medicine, ... , The new GSCG clinic is headed by four prominent Ecuadorian physicians, including ...
(Date:2/10/2016)... Md. , Feb. 10, 2016  The Maryland ... Busch , has announced that University of Maryland School ... PhD, MBA and University of Maryland Medical System President ... of the "Speaker,s Medallion," the highest honor given to ... of Delegates. Dean Reece and Mr. ...
(Date:2/10/2016)... and New York, New York (PRWEB) , ... ... ... Regeneron Pharmaceuticals Inc. (NASDAQ: REGN) today announced that it has joined ... new vaccines and immunotherapies for infectious diseases and cancer. , The ...
Breaking Biology Technology: