Navigation Links
Development of new anti-cancer gene therapy approach using lentiviral vectors
Date:3/29/2010

Neuherberg, March 29, 2010. Helmholtz Zentrum Mnchen has launched a new cooperative project with SIRION BIOTECH GmbH in Martinsried to develop new therapeutic approaches against lymphoid tumors. With a two-year grant from the Federal Ministry for Economics and Technology, the two partners will seek to further develop lentiviral vector systems to better understand the disease mechanisms of this cancer form and to devise approaches for treatment.

The future of gene therapy approaches in cancer treatment is especially dependent on the quality of the vectors involved in the regulation of gene expression in the tumor cells. Lentiviruses are a very promising vector system for this they even reach difficult-to-access cell types such as the hematopoietic cells of the blood-forming system.

With their new research cooperation Helmholtz Zentrum Mnchen and SIRION BIOTECH seek to optimize the use of lentiviruses as gene vectors for hematopoietic cells. Over the long term this may result in an important step forward in the therapy of malignant lymphomas. The Federal Ministry for Economics and Technology is funding the project over the next two years with approximately 500,000 euros.

"We quite consciously decided on a cooperation partner from the biotech sector," said Professor Gnther Wess, scientific-technical director of Helmholtz Zentrum Mnchen. "The symbiosis of our scientific expertise in the field of lentiviruses with the technical know-how of SIRION BIOTECH promises to yield valuable insights about the molecular disease mechanisms and the function of disease-relevant genes in the blood cells."

Dr. Nataa Anastasov, who is in charge of the project at the Institute of Radiation Biology of Helmholtz Zentrum Mnchen, and her colleagues from SIRION BIOTECH already have concrete ideas regarding the new generation of lentiviruses: "We want to specifically refine the lentiviral vectors to target the tumor cell markers." To achieve this, the researchers first want to develop new cell lines in the laboratory with improved binding characteristics for virus production.

"We are very pleased that Helmholtz Zentrum Mnchen has chosen to cooperate with our company due to our specialization in genetically modified cells and viral vector technologies," said Dr. Jrgen Flach, CEO of SIRION BIOTECH. Both cooperation partners are confident that over the long term they can make an important contribution to the treatment of lymphomas.


'/>"/>

Contact: Sven Winkler
presse@helmholtz-muenchen.de
49-898-931-873-946
Helmholtz Zentrum Mnchen - German Research Center for Environmental Health
Source:Eurekalert

Related biology news :

1. Compound screening for drug development made simpler
2. Quickly and easily integrate fingerprint biometric features into portable applications with Texas Instruments comprehensive, low cost fingerprint development kit
3. Chemists influence stem-cell development with geometry
4. Opposing functions of a key molecule in the development of organisms
5. Development of more muscular trout could boost commercial aquaculture
6. Sonic hedgehog gene found in an unexpected place during limb development
7. Model may offer better understanding of embryonic development
8. Chemical competition: Research identifies new mechanism regulating embryonic development
9. ACS webinar features developments in online water and wastewater monitoring
10. Rondaxe and TD2 form strategic drug development alliance
11. Zebrafish swim into drug development
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/31/2016)... -- Genomics firm Nabsys has completed a financial  restructuring under ... M.D., who returned to the company in October 2015. ... including Chief Technology Officer, John Oliver , Ph.D., ... Vice President of Software and Informatics, Michael Kaiser ... Bready served as CEO of Nabsys from 2005-2014 and ...
(Date:3/22/2016)... PROVO and SANDY, ... Screening Ontario (NSO), which operates the highest sample volume ... testing, and Tute Genomics and UNIConnect, leaders in clinical ... today announced the launch of a project to establish ... testing panel. NSO has been contracted ...
(Date:3/15/2016)... 15, 2016 --> ... Transparency Market Research "Digital Door Lock Systems Market - Global ... 2023," the global digital door lock systems market in terms ... and is forecast to grow at a CAGR of 31.8% ... and medium enterprises (MSMEs) across the world and high industrial ...
Breaking Biology News(10 mins):
(Date:5/20/2016)... ... May 20, 2016 , ... Kablooe Design, a leading provider ... announced its official 25th anniversary of the business. “We have worked hard to build ... our customers for the privilege and honor of serving their product design and development ...
(Date:5/19/2016)... RIDGE, British Columbia , May 19, 2016 ... AdvanTec Global Innovations Inc. (AGI), based out of ... recently added Greenlane Biogas Ltd. to its existing ... 2-year contract manufacturing agreement. AFS along with its ... Technologies (ABT) is a vertically integrated industrial group ...
(Date:5/19/2016)... May 19, 2016 - I ... orale durante il 52 ° ...    - Le conclusioni dello studio indicano ... pazienti trattati, di cui il 90% presenta una d ... o più. Il settantadue per cento dei pazienti ha riscontrato ...
(Date:5/18/2016)... ... 18, 2016 , ... STACS DNA Inc., the sample tracking software company, today ... assault kit processing to help them save time and reduce errors. , Sexual Assault ... be processed and victims informed of results. Due to a previous lack of tools, ...
Breaking Biology Technology: